Yin and Yang of mitochondrial ROS in Drosophila

Towarnicki, Samuel G.; Kok, Leanne M.; Ballard, J. William O.

doi:10.1016/j.jinsphys.2020.104022

Cited by 10 publications

(4 citation statements)

References 104 publications

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“…42 Excess ROS attack macromolecules such as membrane lipids, proteins, and DNA, causing oxidative damage. 43 In this study, we demonstrated that an accumulation of large amounts of ROS was induced in larvae following exposure to phoxim. This phenomenon has also been reported in other insect species under insecticide treatment.…”

Section: Discussionmentioning

confidence: 62%

“…Various environmental stressors, such as extremely low and high temperatures, toxic plant secondary metabolites, and insecticides, could cause a burst of cellular ROS in insects . Excess ROS attack macromolecules such as membrane lipids, proteins, and DNA, causing oxidative damage . In this study, we demonstrated that an accumulation of large amounts of ROS was induced in larvae following exposure to phoxim.…”

Section: Discussionmentioning

confidence: 62%

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Epsilon Class Glutathione S-Transferase Confers Phoxim Tolerance in the Black Cutworm Agrotis ipsilon (Lepidoptera: Noctuidae)

Cao,

Yu,

Sun

et al. 2023

J. Agric. Food Chem.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 62%

Epsilon Class Glutathione S-Transferase Confers Phoxim Tolerance in the Black Cutworm Agrotis ipsilon (Lepidoptera: Noctuidae)

Cao,

Yu,

Sun

et al. 2023

J. Agric. Food Chem.

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“…Exposure to radiation, ultraviolet light, and some chemicals results in the production of reactive oxygen species (ROS) such as hydrogen peroxide and superoxide anion radical, usually via the mitochondria of cells (Towarnicki et al, 2020). In general, ROS are harmful to living organisms because ROS can cause oxidative damage to proteins, nucleic acids and lipids (Gladyshev 2014;Sies, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Free radicals impair metabolism and necessitate protection and repair especially during starvation, poor diet, desiccation and rehydration. Raising houseflies in an atmosphere of 100% oxygen reduced their mean and maximum life span and it increased their levels of protein carbonyls in whole body extracts (Sohal et al, 1993) and in the mitochondria (Towarnicki et al, 2020). Cells exposed to low oxygen levels (hypoxia) activate the transcription factor hypoxia-inducible factor 1 (HIF-1) as an adaptive response.…”

mentioning

confidence: 99%

Malathion-resistant Tribolium castaneum has enhanced response to oxidative stress, immunity, and fitness

Rauf

Wilkins

2021

Preprint

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Many cases of insecticide resistance in insect pests give resulting no-cost strains that retain the resistance genes even in the absence of the toxic stressor. Malathion has been widely used against the red flour beetle, Tribolium castaneum Herbst. in stored products although no longer used. Malathion specific resistance in this pest has provided resistance that is long lasting and widely distributed. To understand this resistance a malathion resistant strain was challenged with a range of stressors including starvation, hyperoxia, malathion and a pathogen and the antioxidant responses and some lifecycle parameters were determined. Adult life span of malathion-specific resistant strain of T. castaneum was significantly shorter than the susceptible. Starvation and/or high oxygen reduced adult life span of both strains. Starving with and without 100% oxygen gave longer lifespan for the resistant strain, but for oxygen alone there was no difference. Under oxygen the proportional survival of the resistant strain to the adult stage was significantly higher, for both larvae and pupae, than the susceptible. The resistant strain when stressed with malathion and/or oxygen significantly increased catalase activity, but the susceptible did not. The resistant strain stressed with Paranosema whitei infection had significantly higher survival compared to the susceptible, and with almost no mortality. The malathion resistant strain of T. castaneum showed greater vigour than the susceptible in most oxidative stress situations and especially where stressors were combined. The induction of the antioxidant enzyme catalase could have helped the resistant strain to withstand oxidative stresses, including insecticidal and importantly those from pathogens. These adaptations, in the absence of insecticide, seem to support the increased immunity of host insects to pathogens seen in other insect species, such as mosquitoes. By increasing the responses to a range of stressors the resistant strain could be considered as having enhanced fitness.

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From Natural Behavior to Drug Screening: Invertebrates as Models to Study Mechanisms Associated with Alcohol Use Disorders

Scholz

2023

Current Topics in Behavioral Neurosciences

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Yin and Yang of mitochondrial ROS in Drosophila

Cited by 10 publications

References 104 publications

Epsilon Class Glutathione S-Transferase Confers Phoxim Tolerance in the Black Cutworm Agrotis ipsilon (Lepidoptera: Noctuidae)

Epsilon Class Glutathione S-Transferase Confers Phoxim Tolerance in the Black Cutworm Agrotis ipsilon (Lepidoptera: Noctuidae)

Malathion-resistant Tribolium castaneum has enhanced response to oxidative stress, immunity, and fitness

From Natural Behavior to Drug Screening: Invertebrates as Models to Study Mechanisms Associated with Alcohol Use Disorders

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