YKL-40: A biomarker for early nephropathy in type 2 diabetic patients and its association with inflammatory cytokines

Umapathy, Dhamodharan; Sireesh, Dornadula; Krishnamoorthy, Ezhilarasi; Vairamani, M.; Viswanathan, Vijay; Ramkumar, Kunka Mohanram

doi:10.1016/j.imbio.2018.07.020

Cited by 19 publications

(17 citation statements)

References 27 publications

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“…Serum sTWEAK levels gradually decreased in T2DM patients in line with DN progression [193]. In another study, a negative correlation has been described between TWEAK and YKL-40, a potential biomarker for early diagnosis of incipient DN [198]. In a clinical trial in T2DM hypertensive patients with proteinuria, the combined therapy with RAAS blockers and calcium channel blockers normalized proteinuria, sTWEAK and PTX3 levels [199].…”

Section: Other Cytokines/proinflammatory Proteins In Dnmentioning

confidence: 90%

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

Rayego‐Mateos

Morgado‐Pascual

Opazo-Ríos

et al. 2020

IJMS

187

127

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Diabetic nephropathy (DN) is associated with an increased morbidity and mortality, resulting in elevated cost for public health systems. DN is the main cause of chronic kidney disease (CKD) and its incidence increases the number of patients that develop the end-stage renal disease (ESRD). There are growing epidemiological and preclinical evidence about the close relationship between inflammatory response and the occurrence and progression of DN. Several anti-inflammatory strategies targeting specific inflammatory mediators (cell adhesion molecules, chemokines and cytokines) and intracellular signaling pathways have shown beneficial effects in experimental models of DN, decreasing proteinuria and renal lesions. A number of inflammatory molecules have been shown useful to identify diabetic patients at high risk of developing renal complications. In this review, we focus on the key role of inflammation in the genesis and progression of DN, with a special interest in effector molecules and activated intracellular pathways leading to renal damage, as well as a comprehensive update of new therapeutic strategies targeting inflammation to prevent and/or retard renal injury.

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Section: Other Cytokines/proinflammatory Proteins In Dnmentioning

confidence: 90%

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

Rayego‐Mateos

Morgado‐Pascual

Opazo-Ríos

et al. 2020

IJMS

187

127

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“…[ 19 20 21 ] YKL-40 is stimulated by locally pro-inflammatory cytokines such as TNF-α and IL-1β. [ 4 ] YKL-40 levels correlated with pro-inflammatory TNFα and IL-1β levels. [ 22 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 31 ] YKL-40 was positively correlated with IR. [ 4 ] YKL-40 was inversely correlated with insulin-like growth factor 1. [ 32 ]…”

Section: Discussionmentioning

confidence: 99%

“…Chitinase-3-like protein1 YKL-40 is a 40 kDa heparin and chitin-binding glycoprotein that has three N terminal amino acids: tyrosine (Y), lysine (K), and leucine (L). [ 4 ] It is produced by inflammatory cells as neutrophils, endothelial cells, macrophages, fibroblasts, chondrocytes and cells of smooth muscle. [ 5 ] Although YKL-40 biological function is unknown, YKL-40 participation has been also evidenced during extracellular matrix remodeling, migration and proliferation of (malignant) cells, angiogenesis, macrophage-induced inflammation, and T-cell activity.…”

Section: Introductionmentioning

confidence: 99%

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YKL-40 a sensitive biomarker for early androgenetic alopecia and early hidden metabolic syndrome

Elhabak

Halim

2020

Int J Trichol

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Background: Androgenetic alopecia (AGA) is a common dermatological problem, Does the onset of the AGA matters in the general health? YKL 40 may have role in the pathogenesis of early AGA and associated metabolic syndrome (MS). YKL 40, released by many inflammatory cells and its biological role is not well known. Aim of the Work: The estimation of serum level of YKL-40 in patients with AGA to detect its role in AGA and MS pathogenesis, onset and severity. Materials and Methods: This case–control study, 100 individuals were enrolled in our study; 70 AGA patients and 30 healthy controls. We obtained an informed written consent from each individual prior the participation. AGA was diagnosed clinically, and onset was evaluated as early onset alopecia (by the age of 30 years or earlier), YKL-40 level was measured by ELISA technique. Results: Patients showed highly significant higher serum YKL-40 level more than that of the healthy subjects ( P < 0.001). There was highly significant increase in YKL-40 level among early onset male and female cases compared to late onset cases ( P < 0.001 each). There was significant increase in MS elements in AGA cases than controls ( P < 0.05), and highly significant increase in MS associations and severity among early onset male and female cases compared to late onset cases ( P < 0.001 each). AGA patients with MS showed highly significant higher serum YKL-40 level more than that without ( P < 0.001). There was highly significant increase in YKL-40 level among early onset AGA with MS compared to late onset cases with MS ( P < 0.001 each). Conclusions: High serum YKL-40 considered not only a biomarker of early onset AGA but also considered a potential sensitive predictor for early onset MS development and severity in patients with early onset AGA.

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“…YKL-40, also known as chitinase 3-like protein 1 (CHI3L1), is an inflammatory glycoprotein secreted by a variety of cells, particularly by activated macrophages and neutrophils, in different tissues with inflammation [31,32]. It is also produced by vascular smooth muscle cells in response to endothelial damage [32].…”

Section: Introductionmentioning

confidence: 99%

Glycoprotein YKL-40 Is Elevated and Predicts Disease Severity in Puumala Hantavirus Infection

Outinen

Mantula

Jaatinen

et al. 2019

Viruses

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Most cases of hemorrhagic fever with renal syndrome (HFRS) in Europe are caused by the Puumala hantavirus (PUUV). Typical features of the disease are increased vascular permeability, acute kidney injury (AKI), and thrombocytopenia. YKL-40 is an inflammatory glycoprotein involved in various forms of acute and chronic inflammation. In the present study, we examined plasma YKL-40 levels and the associations of YKL-40 with disease severity in acute PUUV infection. A total of 79 patients treated in Tampere University Hospital during 2005–2014 were studied. Plasma YKL-40 was measured in the acute phase, the recovery phase, and one year after hospitalization. Plasma YKL-40 levels were higher during the acute phase compared to the recovery phase and one year after hospitalization (median YKL-40 142 ng/mL, range 11–3320, vs. 45 ng/mL, range 15–529, vs. 32 ng/mL, range 3–213, p < 0.001). YKL-40 level was correlated with the length of hospital stay (r = 0.229, p = 0.042), the levels of inflammatory markers—that is, blood leukocytes (r = 0.234, p = 0.040), plasma C-reactive protein (r = 0.332, p = 0.003), and interleukin-6 (r = 0.544, p < 0.001), and maximum plasma creatinine level (r = 0.370, p = 0.001). In conclusion, plasma YKL-40 levels were found to be elevated during acute PUUV infection and correlated with the overall severity of the disease, as well as with the degree of inflammation and the severity of AKI.

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YKL-40: A biomarker for early nephropathy in type 2 diabetic patients and its association with inflammatory cytokines

Cited by 19 publications

References 27 publications

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

YKL-40 a sensitive biomarker for early androgenetic alopecia and early hidden metabolic syndrome

Glycoprotein YKL-40 Is Elevated and Predicts Disease Severity in Puumala Hantavirus Infection

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