YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints

Väänänen, Tuija; Koskinen, Anna; Paukkeri, Erja-Leena; Hämäläinen, Mari; Moilanen, Teemu; Moilanen, Eeva; Vuolteenaho, Katriina

doi:10.1155/2014/215140

Cited by 57 publications

(38 citation statements)

References 26 publications

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“…The circulating levels of YKL-40 in patients with RCC detected in the present study were higher than those in healthy people or in patients with other diseases measured in our laboratory recently [13][14][15]. Increased levels of YKL-40 have been associated with diseases characterized by acute or chronic inflammation and also with cancer [4].…”

Section: Discussioncontrasting

confidence: 39%

High YKL-40 is associated with poor survival in patients with renal cell carcinoma: a novel independent prognostic marker

Väänänen

Kallio

Vuolteenaho

et al. 2017

Scandinavian Journal of Urology

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Objective: YKL-40 is an inflammation-associated glycoprotein supposed to have a role in cell survival and angiogenesis. RCC is characterized by varying prognosis and risk of relapse after disease free time of years. Prognostic markers are critically needed. We investigated if YKL-40 could serve as a useful biomarker in RCC patients. Materials and Methods: Blood samples from 82 patients with RCC were collected at the time of diagnosis and 3, 5, and 9 months and 2 and 3 years after nephrectomy. Levels of YKL-40 were determined by ELISA. Survival of patients and relapse of RCC was followed up to 15 years.Results: Circulating YKL-40 levels were increased in patients with metastatic RCC at the time of diagnosis (115.7, 61.0-221.6 ng/ml; median, IQR). More importantly, among patients primarily diagnosed to have nonmetastatic RCC, baseline YKL-40 levels were significantly higher in those patients who experienced a relapse during the follow-up (103.7, 59.3-242.0 ng/ml) than in patients without relapse (50.6, 33.8-97.1 ng/ml). Moreover, high baseline YKL-40 was highly associated with poor prognosis in RCC: in age-adjusted univariate analysis, YKL-40 over 120 ng/ml (highest tertile) predicted over 5-fold mortality in 5 years, and in multivariate analysis high YKL-40 stayed as a statistically significant independent risk factor for 5 and 15 years survival. Conclusions:Increased circulating YKL-40 levels were found to be significantly associated with poor survival in patients with RCC. The results suggest YKL-40 as a useful novel biomarker in evaluating prognosis and relapse risk in RCC, being especially beneficial in patients primarily diagnosed to have nonmetastatic RCC.

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Section: Discussioncontrasting

confidence: 39%

High YKL-40 is associated with poor survival in patients with renal cell carcinoma: a novel independent prognostic marker

Väänänen

Kallio

Vuolteenaho

et al. 2017

Scandinavian Journal of Urology

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“…A growing number of investigations have found that the recently discovered glycoprotein YKL-40 could be involved in the inflammatory joint process. YKL-40, the human chitinase 3-like-1 protein, is linked to different mediators of inflammation and cartilage damage [25]. It has been shown that YKL-40 synthesis is related to joint inflammation, tissue remodeling, and alteration of cartilage in OA joint [26].…”

Section: Discussionmentioning

confidence: 99%

Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

et al. 2018

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The aim of our study was to analyze the level of the glycoprotein YKL-40 in patients with active knee osteoarthritis (OA) and to search possible correlations with local inflammation and ultrasound (US) findings.Material and methods: A prospective study with fifty consecutive patients with active knee OA (diagnosed based on the American College of Rheumatology criteria for OA with radiographic confirmation) was performed. Concentrations of YKL-40 in serum and synovial fluid were measured by ELISA. US examinations – Gray scale (GS) US and Power Doppler (PD) US – of the knee was performed according to international guidelines. The suprapatellar, medial and lateral parapatellar recesses were scanned in each knee to evaluate synovial hypertrophy and vascularization.Results: Forty women (mean age 61.50±11.33 years old) and 10 men (aged 68.50±6.60 years old) were enrolled. We found that the synovial level of the glycoprotein (237.80±104.08 ng/ml) was significantly higher compared to the serum concentration (112.83±60.61 ng/ml, p<0.001). The serum concentration in OA patients was higher comparing with age-matched healthy controls (84.19±11.39 ng/ml) (p<0.05). A statistically significant association between YKL- 40 in synovial fluid and serum levels was shown. We determined a moderately positive linear relationship between the synovial level of the glycoprotein and the serum concentration. No association between the levels of inflammatory markers – erythrocyte sedimentation rate and C-reactive protein – and YKL-40 concentrations was detected. Our study revealed a strong relationship between YKL-40 in synovial fluid and GS US and feeble with PD US. YKL-40 correlated with inflammatory activity in knee joints and neovascularization detected by US.Conclusions: YKL-40 is involved in the pathogenesis of OA synovitis. Evaluation of YKL-40 levels in parallel with US might provide more sensitive and reliable information for the diagnosis and understanding of OA.

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“…Proinlammatory interleukins, such as IL-2, IL-6, IL-12, IL-13, IL-17, and IL-18, did not induce YKL-40 transcription in astrocytes [23], while IL-6 and IL-17 showed enhanced production in human primary chondrocyte culture [22,24].…”

Section: Ykl-40 Regulationmentioning

confidence: 93%

“…Other studies indicated that YKL-40 increased also in inlammatory disorders associated with tissue remodeling and destruction [24,49].…”

Section: Proposed Functions For Ykl-40mentioning

confidence: 99%

YKL‐40: The Search for New Biomarkers in Rheumatoid Arthritis

Kazakova¹,

Sarafian²

2017

New Developments in the Pathogenesis of Rheumatoid Arthritis

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There is a need for biomarkers to detect early joint inlammation and destruction of cartilage in diferent types of arthritis. YKL-40, a 39 kDa heparin-and chitin-binding secreted glycoprotein (also known as human cartilage gp39), has been recently discovered. Its exact biological function is still unclear. Speciic receptors for YKL-40 have not been identiied yet. The clinical signiicance of YKL-40 as a biomarker is discussed in diferent aspects. High level of YKL-40 is found in various human i`nlammatory and neoplastic diseases. We present a review highlighting the information available on YKL-40 and its signiicance in inlammatory joint diseases, like rheumatoid arthritis (RA). We also report original personal data on the topic concerning YKL-40 levels in serum and synovial luid of patients with RA in comparison with ultrasonographic parameters and cytokine levels. The indings suggest that YKL-40 might be implicated in the pathogenesis of the disease and could indicate the level of joint inlammation.

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YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints

Cited by 57 publications

References 26 publications

High YKL-40 is associated with poor survival in patients with renal cell carcinoma: a novel independent prognostic marker

High YKL-40 is associated with poor survival in patients with renal cell carcinoma: a novel independent prognostic marker

Correlation between protein YKL-40 and ultrasonographic findings in active knee osteoarthritis

YKL‐40: The Search for New Biomarkers in Rheumatoid Arthritis

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