Untitled

Facile synthesis of cyclic α-perfluoroalkyl-α-aminophosphonates

“…Depending on the structure and electrophilicity of a Schiff base, dialkyl phosphites are known to add to the C N bond under thermal [33], ultrasonic [34] or microwave [35] initiation, in the presence of strong bases [36] or Lewis acids [35,37] to give racemic a-aminophosphonates. Using this strategy, recently we developed the effective synthesis of cyclic a-substituted-a-aminophosphonates 4 with different cyclic size based on the diethylphosphite addition to the C N double bond of easily available a-substituted cyclic imines (Scheme 1) [38].…”

Catalytic Hydrogenation of α‐Iminophosphonates as a Method for the Synthesis of Racemic and Optically Active α‐Aminophosphonates

“…After recrystallization from alcohol the yield of 3a was 0.300 g (60%), mp 89-90 8C. [69][70][71][72] Diethyl a-(p-Anisylamino)benzylphosphonate (3b)…”

An eco-friendly procedure for the efficient synthesis of diethyl α-aminophosphonates in aqueous media using natural acids as a catalyst

“…However, one-pot synthesis of α-aminophosphonates remains a favorite due to its versatile route and high-yielding reactions. In the last few decades, intensive synthetic studies were performed in the preparation of α-aminophosphonic acids and their esters [24][25][26][27][28][29]. The Kabachnik-Fields (phospha-Mannich) reaction involving the condensation of primary or secondary amines, oxo compounds (aldehydes and ketones) and >P(O)H species, especially dialkyl phosphites, represents a good choice for the synthesis of α-aminophosphonates that are of significant importance due to their biological activity.…”