Yoga is an ancient Indian practice for holistic well-being through physical, mental, spiritual harmony. And Pranayama, a part of Yoga is a breath control technique to enhance vitality, mental clarity and spiritual growth. Clinical Therapeutic Pranayama, a subset of yoga, utilizes controlled breathing to manage health issues. Techniques like Nadi Shodhana, Bhramari, Ujjayi, Kapalabhati, Sitali, and Bhastrika target specific benefits such as stress reduction, improved focus, and enhanced lung capacity. These practices, rooted in ancient Sanskrit principles, aim to harmonize physical, mental, and spiritual well-being through conscious breath regulation. The present study is a Quasi-Experimental study. A sample of 30 subjects, by using purposive sampling technique, were selected to study the effect Clinical Therapeutic Pranayama (viz. Bhramri Pranayama) on the population of preferably both sexes (males as well as females) under the age group of 18 years to 60 years who are under Quarantine and isolation period in Pandemic COVID 19. Participants who meet the Inclusion and exclusion criteria are recruited for the study via survey method. Participants are randomly divided into two groups; one treatment group and another control group with 15 participants in each group. The groups are assessed for psychosocial condition by using 'COVID19 Psychological Symptoms Checklist'. Pre-test and post-test (after intervention) are conducted. Experimental group is treated with Clinical Therapeutic Pranayama for two weeks daily in the morning. Whereas, Control group is given instructions to hear any kind of relaxing music as they seem beneficial for them as a placebo. The study provides compelling evidence supporting the effectiveness of Clinical Therapeutic Pranayama in enhancing the psychosocial management of individuals undergoing quarantine or isolation during the COVID19 pandemic.