Yoga improves mitochondrial health and reduces severity of autoimmune inflammatory arthritis: A randomized controlled trial

Kumar, Uma; Kumar, Manoj; Rana, Deeksha; Dada, Rima

doi:10.1016/j.mito.2021.03.004

Cited by 31 publications

(33 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasingly, yoga is used in the management of specific health conditions that affect many older people. These include chronic obstructive pulmonary disease [21], cardiovascular disease and metabolic syndrome [22], rheumatoid arthritis [23], osteoarthritis [24], stroke [25] and different forms of musculoskeletal pain [26][27][28][29]. Yoga can also uniquely affect people's physical self-regard, facilitating positive body image and self-compassion, and shifting focus from external physicality to more functional or internal aspects of the body.…”

Section: Yoga As a Practise For Healthy Ageingmentioning

confidence: 99%

What helps older people persevere with yoga classes? A realist process evaluation of a COVID-19-affected yoga program for fall prevention

et al. 2022

View full text Add to dashboard Cite

Background Falls among older people are a major global health concern. This process evaluation investigates the experience of participants aged 60+ in a yoga program aimed at preventing falls which transitioned from studio-based classes to online classes in response to COVID-19 restrictions. We sought to understand how the Successful AGEing (SAGE) yoga program functioned in both settings and as a hybrid program, and to explain why it worked well for most participants. Methods Realist process evaluation was used to explore the factors that facilitated a successful transition for most participants, and to consider why it did not work for a minority. This approach develops program theories that describe which mechanisms an intervention is (or is not) activating, and how this is mediated by context to generate process outcomes. Data included interviews with participants (n = 21) and yoga instructors (n = 3), self-report feedback forms (n = 46), observation of classes and routine process measures. Results Factors that facilitated a successful transition for most participants included the quality of yoga instruction, the program format and inherent characteristics of yoga. Gains in transitioning online included continuity and greater convenience. Losses included perceived reduction in the effectiveness of yoga instruction. There were greater challenges for people struggling with pain and in disadvantageous home environments. We identified six program theories configured around 16 mechanisms: 1. It’s worth the effort and 2. In expert hands (these had the same mechanisms: value expectancy, therapeutic alliance and achievement/mastery), 3. A communal experience (these mechanisms were shared experience, social connection, social comparison and peer checking), 4. Putting yoga within reach (accessibility, convenience, gratitude), 5. Building yoga habits (purposeful structure, momentum, accountability and continuity), and 6. Yoga’s special properties (embodiment and mindfulness). Conclusions This study showed that online delivery of a yoga program for people aged 60+ retained much of the value of a face-to-face program for the majority of participants, and increased the value for some. The structured, communal nature of an organised group program delivered by a skilled instructor, together with yoga’s intrinsic focus on mindfulness, facilitated continued engagement and perceived health benefits, despite the change in delivery mode.

show abstract

Section: Yoga As a Practise For Healthy Ageingmentioning

confidence: 99%

What helps older people persevere with yoga classes? A realist process evaluation of a COVID-19-affected yoga program for fall prevention

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Moreover, the optimization of oxidative stress markers (lower ROS and higher total antioxidant capacity) and circadian rhythm markers (lower cortisol and higher melatonin, and higher serotonin) was also observed. In summary, regular yoga practice in rheumatoid arthritis patients could enhance mitochondrial health and reduce disease activity; therefore, it could be beneficial as an adjunct therapy [ 100 ].…”

Section: Proposed Mhi or Bhi Alterationsmentioning

confidence: 99%

Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine

et al. 2022

View full text Add to dashboard Cite

Mitochondria are the “gatekeeper” in a wide range of cellular functions, signaling events, cell homeostasis, proliferation, and apoptosis. Consequently, mitochondrial injury is linked to systemic effects compromising multi-organ functionality. Although mitochondrial stress is common for many pathomechanisms, individual outcomes differ significantly comprising a spectrum of associated pathologies and their severity grade. Consequently, a highly ambitious task in the paradigm shift from reactive to predictive, preventive, and personalized medicine (PPPM/3PM) is to distinguish between individual disease predisposition and progression under circumstances, resulting in compromised mitochondrial health followed by mitigating measures tailored to the individualized patient profile. For the successful implementation of PPPM concepts, robust parameters are essential to quantify mitochondrial health sustainability. The current article analyses added value of Mitochondrial Health Index (MHI) and Bioenergetic Health Index (BHI) as potential systems to quantify mitochondrial health relevant for the disease development and its severity grade. Based on the pathomechanisms related to the compromised mitochondrial health and in the context of primary, secondary, and tertiary care, a broad spectrum of conditions can significantly benefit from robust quantification systems using MHI/BHI as a prototype to be further improved. Following health conditions can benefit from that: planned pregnancies (improved outcomes for mother and offspring health), suboptimal health conditions with reversible health damage, suboptimal life-style patterns and metabolic syndrome(s) predisposition, multi-factorial stress conditions, genotoxic environment, ischemic stroke of unclear aetiology, phenotypic predisposition to aggressive cancer subtypes, pathologies associated with premature aging and neuro/degeneration, acute infectious diseases such as COVID-19 pandemics, among others.

show abstract

“…8 Yoga improves the mitochondrial integrity by altering the expression levels of transcripts that maintain mitochondrial integrity, which aids in the maintenance of optimal free radical levels, holds the key to increase the mitochondrial copy number, improves COX-II activity, increases NAD+ levels, optimizes OS markers, and increases the expression levels of transcripts that maintain mitochondrial integrity, reduces disease activity and its associated consequences on physical and mental health,and hence can be beneficial as an adjunct therapy. 4,22,23 The regulation of cellular OS within physiological limits after YBLI suggests the potential of this intervention in protecting cells from OS-induced nuclear and mt DNA damage and telomere attrition and in reversing epigenetic changes, which accumulate due to unhealthy lifestyle and adverse environmental conditions. The multifaceted dimensions of yoga enhance psychological and physical health by its underlying cumulative effects on maintaining the mitochondrial and nuclear genome.Yoga is a cost-effective emerging health discipline which unlike drugs has no sideeffects and aids in reducing disease severity, optimizes OS levels, increases transcript levels associated with immune homeostasis, immune system metabolism, mitochondrial architecture, and mitochondrial biogenesis, and hence has the immense potential to be used as an adjunct therapy in the management of mitochondrial diseases.…”

Section: Manuscriptmentioning

confidence: 99%

“… 20 A study from our laboratory documented positive effects of YBLI in RA, which is a severe autoimmune inflammatory disorder characterized by chronic pain and swelling, primarily affecting the peripheral joints. 21 , 22 , 23 Our recent randomized controlled trial (RCT) on the impact of yoga on RA patients published in Frontiers in Psychology , 2020 supports yoga as an adjunctive therapy to treat this chronic progressive debilitating disease as it aids in decreasing systemic inflammation by its beneficial effects on the psycho-neuro-immune axis and normalization of dysregulated transcripts ( IL-6, TNF-α, NFKB1, TGF-β , and CTLA4 ). 8 Yoga improves the mitochondrial integrity by altering the expression levels of transcripts that maintain mitochondrial integrity, which aids in the maintenance of optimal free radical levels, holds the key to increase the mitochondrial copy number, improves COX-II activity, increases NAD+ levels, optimizes OS markers, and increases the expression levels of transcripts that maintain mitochondrial integrity, reduces disease activity and its associated consequences on physical and mental health,and hence can be beneficial as an adjunct therapy.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Yoga—Impact on Mitochondrial Health: Clinical Consequences

Saxena

Dada

2021

Annals of Neurosciences

Self Cite

View full text Add to dashboard Cite

A broad range of degenerative disorders present with an underlying mitochondrial dysfunction. Various environmental triggers such as air pollutants, smoking, and poor lifestyle induce oxidative stress, which may compromise mitochondrial integrity. An adoption of yoga-based lifestyle may hold the key to increase mitochondrial copy number, optimize oxidative stress markers, and increase the expression levels of transcripts that maintain mitochondrial integrity, and reduce associated consequences on physical and mental health,and hence can be beneficial as an adjunct therapy.

show abstract

Yoga improves mitochondrial health and reduces severity of autoimmune inflammatory arthritis: A randomized controlled trial

Cited by 31 publications

References 84 publications

What helps older people persevere with yoga classes? A realist process evaluation of a COVID-19-affected yoga program for fall prevention

What helps older people persevere with yoga classes? A realist process evaluation of a COVID-19-affected yoga program for fall prevention

Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine

Yoga—Impact on Mitochondrial Health: Clinical Consequences

Contact Info

Product

Resources

About