Yogurt consumption and risk of mortality from all causes, CVD and cancer: a comprehensive systematic review and dose–response meta-analysis of cohort studies

Abstract

Objectives: To quantify the dose-response relation between yogurt consumption and risk of mortality from all causes, cardiovascular disease (CVD), and cancer. Design: Systematic review and meta-analysis. Setting: We conducted a comprehensive search of PubMed/Medline, ISI Web of Science, and Scopus databases through August 2022 for cohort studies reporting the association of yogurt consumption with mortality from all causes, CVD, and cancer. Summary relative risks and 95% confidence intervals (CIs) were calculated with a random effects model. Participants: 17 cohort studies (18 publications) of 896871 participants with 75791 deaths (14623 from CVD and 20926 from cancer). Results: High intake of yogurt compared with low intake was significantly associated with a lower risk of deaths from all causes (pooled relative risk 0.93; 95%CI: 0.89-0.98, I2=47.3%, n= 12 studies) and CVD (0.89; 95% CI: 0.81-0.98, I2 =33.2%, n=11), but not with cancer (0.96; 95% CI: 0.89-1.03, I2 =26.5%, n=12). Each additional serving of yogurt consumption per day was significantly associated with a reduced risk of all-cause (0.93; 95% CI: 0.86-0.99, I2 =63.3%, n=11) and CVD mortality (0.86; 95% CI: 0.77-0.99, I2 =36.6%, n=10). There was evidence of non-linearity between yogurt consumption and risk of all-cause and CVD mortality, and there was no further reduction in risk above 0.5 serving/day. Conclusion: Summarizing earlier cohort studies, we found an inverse association between yogurt consumption and risk of all-cause and CVD mortality; however, there was no significant association between yogurt consumption and risk of cancer mortality.

A Review of Healthy Dietary Choices for Cardiovascular Disease: From Individual Nutrients and Foods to Dietary Patterns

“…Moreover, non-fermented milk intake was associated with an increased risk for developing cardiometabolic diseases [160]. In a recent meta-analysis of cohort studies with 896,871 participants, an inverse association between yogurt consumption and risk of all-cause and CVD mortality was found, whereas there was no significant association between yogurt consumption and risk of cancer mortality [161].…”

Substitution of Dairy Products and Risk of Death and Cardiometabolic Diseases: A Systematic Review and Meta-Analysis of Prospective Studies

“…Regarding T2D [ 7 , 8 ] and stroke [ 9 ], inverse associations were shown for each daily serving increase in dairy intake, whereas no association with CAD was found for each daily serving increase in total dairy, whole-fat dairy, low-fat dairy, milk, cheese, and yogurt intake [ 9 , 10 ]. Moreover, dairy intake (per serving increase) showed a neutral association with all-cause mortality [ 60 ] and CVD mortality [ 60 , 61 ], whereas each additional serving of yogurt per day was associated with a reduced risk of all-cause (by 7%) and CVD mortality (by 14%) [ 62 ]. Previous meta-analyses also suggest that higher meat intake, especially processed meat, was associated with an increased risk of T2D [ 7 ], CAD, and stroke [ 10 ], as well as all-cause mortality [ 63 ].…”

Characterization of the Composition Variation of Healthy Human Gut Microbiome in Correlation with Antibiotic Usage and Yogurt Consumption

“…Yogurt consumption was reported to be good for human health, and is especially deemed beneficial to the human gut [ 22 ]. Yogurts made with Bifidobacterium lactis and other probiotics are considered to help maintain gut flora by providing organisms that are usually inhabited in the human gut [ 23 ]. However, we need to be careful when antimicrobial resistance is taken into consideration.…”