Yolk-shell structured nanoreactor Au@Co3O4/CeO2@mSiO2 with superior peroxidase-like activity as nanozyme for ultra-sensitive colorimetric biosensing

Jiao, Chaonan; Zhu, Ying; Ji, Te; Cai, Xiujun; Wang, Jing

doi:10.1016/j.talanta.2023.124571

Cited by 7 publications

(3 citation statements)

References 57 publications

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“…As a catalyst, the more active sites on the nanozyme, the higher the catalytic activity. , So we measured the specific surface area and pore size distribution of CoS nanospheres using the N 2 adsorption–desorption isotherm. As shown in Figure S2b, the specific surface area of CoS nanozyme was calculated up to 41.937 m 2 /g, which might be attributed to its unique hollow spherical structure.…”

Section: Resultsmentioning

confidence: 99%

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Wu,

Liu,

Huang

et al. 2023

Bioconjugate Chem.

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The emergence of nanozymes presents a promising alternative to antibiotics for reactive oxygen species-mediated broad-spectrum antimicrobial purposes, but nanozymes still face challenges of low therapeutic efficiency and poor biocompatibility. Herein, we creatively prepared a novel kind of hollow cobalt sulfide (CoS) nanospheres with a unique mesoporous structure that is able to provide numerous active sites for enzyme-like reactions. The results revealed that 50 μg/mL of CoS nanospheres exhibited strong peroxidase- and oxidase-like activities under physiological conditions with the assistance of a low concentration of hydrogen peroxide (H2O2, 100 μM) while possessing highly efficient GSH-depletion ability, which endowed CoS nanospheres with triple enzyme-like properties to combat bacterial infections. The in vitro experiments demonstrated that the CoS nanozyme displayed significant antibacterial effects against both Gram-positive Staphylococcus aureus (S. aureus) and Gram-negative Escherichia coli (E. coli). The in vivo implantation showed that the synthesized CoS effectively eliminated bacteria and promoted the recovery of infected wounds in rats while exhibiting a low cytotoxicity. This study provides a promising treatment strategy to accelerate infected wound healing.

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Section: Resultsmentioning

confidence: 99%

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Wu,

Liu,

Huang

et al. 2023

Bioconjugate Chem.

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“…The increasingly popular mimetic enzymes that have been utilized to date include metal-organic frameworks, metal chalcogenides, inorganic nanomaterials, nanodots quantum dots, etc. [9,10] The shortcomings of HRP are overcome by these mimic enzymes, which also encourage the creation of synthetic enzyme mimics. Unfortunately, some of these non-biological catalysts require several stages of preparation and modification to prevent aggregation, which would lead to poor repeatability, high time consumption, and weak catalytic activity.…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Copper Telluride Nanoparticles as a Robust Nanoenzymatic Catalyst for Intrinsic Peroxidase‐Like Activity

Chauhan,

Sharma,

Buhari

et al. 2024

ChemistrySelect

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Copper telluride nanoparticles are classified as the family of metal chalcogenides and were synthesized using a simple solvothermal method using a new source of telluride, ditelluride diphenyl. The characterized techniques revealed that the atomic composition of copper tellurides is Cu2Te and particles are spherical. This study is greatly examined by different designed experiments for the proof of the intrinsic peroxidase‐like activity of copper telluride nanoparticles and its effectiveness in a variety of similar structures. Cu2Te nanoparticles can convert peroxidase substrates (TMB and OPD) to colored products in the presence of H2O2. In addition, the as‐prepared nanoparticles have the potential to oxidize DPPH and ABTS substrates. Michaelis–Menten constant KM value for TMB and H2O2 was found to be 12 mM and 0.60 mM for H2O2 and the Vmax value of the Cu2Te was found to be TMB and H2O2 was 2.50×10−7 and 0.82×10−8 MS−1. These data are found to be almost comparable with natural peroxidase HRP and other artificial enzymes reported in the literature. The natural peroxidase‐like activities of Cu2Te nanoparticles originated from the catalytic decomposition of H2O2 into ⋅OH radical, which was confirmed from the ESR spin‐trapping technique and using a fluorescence probe, terephthalic acid.

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“…For this consideration, electrochemical immunosensors, DNA sensors, and aptasensors have been widely developed through enzymatic reaction plus redox cycling [ 34 , 35 , 36 , 37 ]. The integration of redox cycling and enzymatic catalysis can also be introduced into optical bioassays, including fluorescence [ 38 , 39 ], colorimetry [ 40 , 41 , 42 ], and surface-enhanced Raman scattering spectroscopy [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Overview on the Development of Electrochemical Immunosensors by the Signal Amplification of Enzyme- or Nanozyme-Based Catalysis Plus Redox Cycling

Xia,

Gao,

Zhang

et al. 2024

Molecules

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Enzyme-linked electrochemical immunosensors have attracted considerable attention for the sensitive and selective detection of various targets in clinical diagnosis, food quality control, and environmental analysis. In order to improve the performances of conventional immunoassays, significant efforts have been made to couple enzyme-linked or nanozyme-based catalysis and redox cycling for signal amplification. The current review summarizes the recent advances in the development of enzyme- or nanozyme-based electrochemical immunosensors with redox cycling for signal amplification. The special features of redox cycling reactions and their synergistic functions in signal amplification are discussed. Additionally, the current challenges and future directions of enzyme- or nanozyme-based electrochemical immunosensors with redox cycling are addressed.

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Yolk-shell structured nanoreactor Au@Co3O4/CeO2@mSiO2 with superior peroxidase-like activity as nanozyme for ultra-sensitive colorimetric biosensing

Cited by 7 publications

References 57 publications

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Hollow Cobalt Sulfide Nanospheres with Highly Enzyme-like Antibacterial Activities to Accelerate Infected Wound Healing

Facile Synthesis of Copper Telluride Nanoparticles as a Robust Nanoenzymatic Catalyst for Intrinsic Peroxidase‐Like Activity

Overview on the Development of Electrochemical Immunosensors by the Signal Amplification of Enzyme- or Nanozyme-Based Catalysis Plus Redox Cycling

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