Tobacco dependency remains a persistent global public health challenge, with significant implications for morbidity, mortality, and healthcare costs. This systematic review presents a comprehensive analysis of tobacco dependency studies conducted in the United Kingdom (UK). The objective is to distill existing research to inform evidence-based interventions and policies targeting this pressing issue. The primary purpose of this systematic review is to provide an up-to-date synthesis of the current state of tobacco dependency in the UK. By examining a wide range of studies, we aim to identify trends, risk factors, and effective interventions, ultimately contributing to the development of targeted strategies for reducing tobacco use in the UK population. A rigorous systematic search across various academic databases yielded a substantial body of evidence encompassing diverse study designs, including epidemiological surveys, qualitative investigations, and intervention trials. Studies meeting predefined inclusion criteria were systematically reviewed and assessed for quality. Key themes explored include the prevalence of tobacco dependency, associated risk factors, intervention effectiveness, and disparities across demographic groups. Our review highlights several critical findings: The prevalence of tobacco dependency in the UK has declined over the past decade, but challenges persist, particularly among vulnerable populations. Multiple risk factors, including socioeconomic status, mental health conditions, and peer influences, contribute to tobacco dependency in the UK. Evidence supports the effectiveness of various interventions, including smoking cessation programs, taxation policies, and public awareness campaigns. Disparities in tobacco dependency exist along demographic lines, necessitating targeted strategies to address these inequalities. Understanding the complex landscape of tobacco dependency in the UK is imperative for informing public health policies and interventions. This systematic review underscores the need for continued efforts to reduce tobacco use, particularly among disadvantaged groups. The identified risk factors and effective interventions provide valuable insights for designing evidence-based strategies to combat tobacco dependency and its associated health and economic burdens. Addressing these challenges is essential for improving the overall well-being and health equity of the UK population.