You can’t fix what isn’t broken: eight weeks of exercise do not substantially change cognitive function and biochemical markers in young and healthy adults

Gourgouvelis, Joanne; Yielder, Paul; Clarke, Sandra; Behbahani, Hushyar; Murphy, Bernadette

doi:10.7717/peerj.4675

Cited by 19 publications

(23 citation statements)

References 67 publications

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“…() but similar to Gourgouvelis et al. (), who assessed plasma CTSB in sedentary young adults after 8 weeks of moderate to vigorous aerobic exercise, we found no changes in serum total or pro‐CTSB levels following 6 weeks of HIIT. However, we observed that larger gains in aerobic capacity were associated with decreases in serum levels of total and pro‐CTSB.…”

Section: Discussionsupporting

confidence: 89%

“…It is interesting to note the similarities in outcome between Gourgouvelis et al. (), who also tested sedentary individuals, and the present work. Indeed, neither study demonstrated an effect of exercise training on BDNF, CTSB, or WM.…”

Section: Discussionsupporting

confidence: 79%

“…; Gourgouvelis et al. ). Consistently, we demonstrated that 6 weeks of HIIT induced gains in aerobic capacity but left serum levels of BDNF and IGF‐1 in sedentary males unaltered.…”

Section: Discussionmentioning

confidence: 97%

“…Lastly, Gourgouvelis et al. (), who assessed executive function, learning and memory using the Cambridge Neuropsychological Test Automated Battery (CANTAB), showed that 8 weeks of moderate‐to‐vigorous aerobic exercise did not change cognitive performance in sedentary, young adults. In the current work, we showed that WM capacity was unaltered after 6 weeks of HIIT in sedentary males.…”

Section: Discussionmentioning

confidence: 99%

“…; Gourgouvelis et al. ), Zoladz and colleagues () demonstrated increased plasma BDNF after 5 weeks of endurance training in physically active male adults. Further, Leckie et al.…”

Section: Introductionmentioning

confidence: 94%

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No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

et al. 2019

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A single bout of aerobic exercise modulates corticospinal excitability, intracortical circuits, and serum biochemical markers such as brain‐derived neurotrophic factor ( BDNF ) and insulin‐like growth factor 1 ( IGF ‐1). These effects have important implications for the use of exercise in neurorehabilitation. Here, we aimed to determine whether increases in cardiorespiratory fitness ( CRF ) induced by 18 sessions of high‐intensity interval training ( HIIT ) over 6 weeks were accompanied by changes in corticospinal excitability, intracortical excitatory and inhibitory circuits, serum biochemical markers and working memory ( WM ) capacity in sedentary, healthy, young males. We assessed motor evoked potential ( MEP ) recruitment curves for the first dorsal interosseous ( FDI ) both at rest and during tonic contraction, intracortical facilitation ( ICF ), and short‐interval intracortical inhibition ( SICI ) using transcranial magnetic stimulation ( TMS ). We also examined serum levels of BDNF , IGF ‐1, total and precursor (pro) cathepsin B ( CTSB ), as well as WM capacity. Compared to pretraining, CRF was increased and ICF reduced after the HIIT intervention, but there were no changes in corticospinal excitability, SICI , BDNF , IGF ‐1, total and pro‐ CTSB , and WM capacity. Further, greater CRF gains were associated with larger decreases in total and pro‐ CTSB and, only in Val/Val carriers, with larger increases in SICI . Our findings confirm that HIIT is efficacious in promoting CRF and show that corticospinal excitability, biochemical markers, and WM are unchanged after 18 HIIT bouts in sedentary males. Understanding how aerobic exercise modulates M1 excitability is important in order to be able to use exercise protocols as an intervention, especially in rehabilitation following brain injuries.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 79%

“…; Gourgouvelis et al. ). Consistently, we demonstrated that 6 weeks of HIIT induced gains in aerobic capacity but left serum levels of BDNF and IGF‐1 in sedentary males unaltered.…”

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

“…; Gourgouvelis et al. ), Zoladz and colleagues () demonstrated increased plasma BDNF after 5 weeks of endurance training in physically active male adults. Further, Leckie et al.…”

Section: Introductionmentioning

confidence: 94%

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No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

et al. 2019

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A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive Performance of Healthy Adults with Self-Perceived Memory Problems

Doma¹,

Lewis²,

Barracato

et al. 2023

Neurol Ther

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Introduction: Cognition refers to brain functions including memory, learning, and thought processing and is increasingly important to individuals. However, impairment of cognitive function is a concern among North American adults. Therefore, effective and reliable treatments are needed. Methods: This randomized, double-blind, placebo-controlled study examined the effects of 42 days of NeurivaÒ supplementation, a whole coffee cherry extract and phosphatidylserine supplement, on memory, accuracy, focus and concentration and learning among 138 healthy adults (40-65 years) with self-reported memory problems. Plasma brain-derived neurotrophic factor (BDNF) levels, Computerized Mental Performance Assessment System (COMPASS) tasks, the Everyday Memory Questionnaire (EMQ), and Go/No-Go tests were assessed at baseline and day 42. Results: As compared to placebo, NeurivaÒ supplementation elicited greater improvements at day 42 in numeric working memory COM-PASS task accuracy outcomes (p B 0.024) which assessed memory, accuracy, and focus and concentration, and reaction time outcomes (p B 0.031) which assessed memory as well as focus and concentration. NeurivaÒ supplementation improved overall accuracy (p = 0.035) in the picture recognition task that assessed memory, accuracy, and learning compared to placebo. No significant differences between groups were observed for BDNF, the EMQ, or Go/No-Go tests. Conclusion: Results suggest 42 days of Neur-ivaÒ supplementation was safe, well tolerated, and beneficial in improving memory, accuracy, focus and concentration, and learning in a healthy adult population with self-reported memory problems.

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Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research

Lee

Formolo

Kong

et al. 2019

International Review of Neurobiology

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You can’t fix what isn’t broken: eight weeks of exercise do not substantially change cognitive function and biochemical markers in young and healthy adults

Cited by 19 publications

References 67 publications

No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

A Randomized, Double-Blind, Placebo-Controlled, Parallel Study Investigating the Efficacy of a Whole Coffee Cherry Extract and Phosphatidylserine Formulation on Cognitive Performance of Healthy Adults with Self-Perceived Memory Problems

Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research

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