You shall not pass! Protective role of autophagic machinery in response to plasma membrane damage triggered by <i>Candida albicans</i> invasion

Lapaquette, Pierre; Ducreux, Amandine; Morel, Étienne; Dalle, Frédéric

doi:10.1080/15548627.2022.2065437

Cited by 4 publications

(2 citation statements)

References 1 publication

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“…The cell membrane is composed of various lipids and proteins [ 91 , 92 , 93 ] and acts as a protective barrier and gatekeeper [ 94 , 95 ]. The cell membrane is a representative semi-permeable membrane that allows certain ions or molecules to pass through it via osmosis but not others [ 96 ].…”

Section: Roles Of Osmotic Pressurementioning

confidence: 99%

Osmotic Pressure and Its Biological Implications

Zheng,

Li,

Shao

et al. 2024

IJMS

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Gaining insight into osmotic pressure and its biological implications is pivotal for revealing mechanisms underlying numerous fundamental biological processes across scales and will contribute to the biomedical and pharmaceutical fields. This review aims to provide an overview of the current understanding, focusing on two central issues: (i) how to determine theoretically osmotic pressure and (ii) how osmotic pressure affects important biological activities. More specifically, we discuss the representative theoretical equations and models for different solutions, emphasizing their applicability and limitations, and summarize the effect of osmotic pressure on lipid phase separation, cell division, and differentiation, focusing on the mechanisms underlying the osmotic pressure dependence of these biological processes. We highlight that new theory of osmotic pressure applicable for all experimentally feasible temperatures and solute concentrations needs to be developed, and further studies regarding the role of osmotic pressure in other biological processes should also be carried out to improve our comprehensive and in-depth understanding. Moreover, we point out the importance and challenges of developing techniques for the in vivo measurement of osmotic pressure.

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Section: Roles Of Osmotic Pressurementioning

confidence: 99%

Osmotic Pressure and Its Biological Implications

Zheng,

Li,

Shao

et al. 2024

IJMS

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“…These data suggest that NFκB activation upon C. albicans infection does not prevent apoptosis or other programmed cell death pathways. The specific mechanism by which NFκB signaling limits fungal-mediated damage remains undetermined, but may involve recently described membrane repair mechanisms of epithelial cells [58,59].…”

Section: Plos Pathogensmentioning

confidence: 99%

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection

Sprague,

Schille,

Allert

et al. 2024

PLoS Pathog

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The opportunistic fungal pathogen Candida albicans thrives on human mucosal surfaces as a harmless commensal, but frequently causes infections under certain predisposing conditions. Translocation across the intestinal barrier into the bloodstream by intestine-colonizing C. albicans cells serves as the main source of disseminated candidiasis. However, the host and microbial mechanisms behind this process remain unclear. In this study we identified fungal and host factors specifically involved in infection of intestinal epithelial cells (IECs) using dual-RNA sequencing. Our data suggest that host-cell damage mediated by the peptide toxin candidalysin-encoding gene ECE1 facilitates fungal zinc acquisition. This in turn is crucial for the full virulence potential of C. albicans during infection. IECs in turn exhibit a filamentation- and damage-specific response to C. albicans infection, including NFκB, MAPK, and TNF signaling. NFκB activation by IECs limits candidalysin-mediated host-cell damage and mediates maintenance of the intestinal barrier and cell-cell junctions to further restrict fungal translocation. This is the first study to show that candidalysin-mediated damage is necessary for C. albicans nutrient acquisition during infection and to explain how IECs counteract damage and limit fungal translocation via NFκB-mediated maintenance of the intestinal barrier.

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Application and value of hydrogen sulfide modulated autophagy in sepsis

Sun

Liu

2023

International Immunopharmacology

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You shall not pass! Protective role of autophagic machinery in response to plasma membrane damage triggered by Candida albicans invasion

Cited by 4 publications

References 1 publication

Osmotic Pressure and Its Biological Implications

Osmotic Pressure and Its Biological Implications

Candida albicans translocation through the intestinal epithelial barrier is promoted by fungal zinc acquisition and limited by NFκB-mediated barrier protection

Application and value of hydrogen sulfide modulated autophagy in sepsis

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