Young adult stimulant users' increased striatal activation during uncertainty is related to impulsivity

Leland, David S.; Arce, Estíbaliz; Feinstein, Justin S.; Paulus, Martin P.

doi:10.1016/j.neuroimage.2006.07.011

Cited by 46 publications

(34 citation statements)

References 28 publications

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“…Human neuropsychological and imaging studies have provided indirect support to this model. The notion that increased impulsivity underlies early stages of drug use is consistent with findings showing that recreational psychostimulant users (those who have minimal or intermittent use of these drugs but do not meet criteria for psychostimulant dependence) have elevated scores on trait measures of impulsivity and poor inhibitory control (indexed by go/no-go or stop-signal tasks) associated with functional alterations of striatal function (Colzato et al 2007;Leland et al 2006;Verdejo-García et al 2010). On the other hand, studies conducted in chronic cocainedependent individuals have underscored the presence of robust and durable impairments on indices of flexibility and perseveration (Ersche et al 2008;Verdejo-García et al 2007a;Woicik et al 2011).…”

Section: Introductionsupporting

confidence: 77%

Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals

et al. 2011

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Section: Introductionsupporting

confidence: 77%

Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals

et al. 2011

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“…Meanwhile, increased dopamine release in the NAc stimulates impulsive behavior (Cole and Robbins 1987;Pattij et al 2006). Administrations of drugs that activate the dopamine system not only in the mPFC but also in the NAc induce rather impaired impulse control in humans (Leland et al 2006) and in animals (van : Milstein et al 2010. However, inhibition of the noradrenaline transporters by atomoxetine induces an increase of dopamine release in the mPFC without affecting dopamine release in the NAc (Bymaster et al 2002) and consequently enhances impulse control (Robinson et al 2008;Tsutsui-Kimura et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex

et al. 2012

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Rationale: Elevated impulsivity is often observed in patients with depression.We recently found that milnacipran, an antidepressant and a serotonin/noradrenaline reuptake inhibitor, could enhance impulse control in rats. However, the neural mechanisms underlying the effects of milnacipran on impulsive action remain unclear.Milnacipran increases not only extracellular serotonin and noradrenaline but also dopamine specifically in the medial prefrontal cortex, which is one of brain regions responsible for impulsive action.

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“…Stimulant-using individuals often demonstrate dysfunctional decision-making, which may predate the initiation of use (Leland et al, 2006; Leland and Paulus, 2005; Paulus et al, 2008). Individuals with a history of methamphetamine use (METH+) in particular appear more influenced by the immediately preceding choice (Paulus et al, 2002), show a rigid stimulus-response relationship (Paulus et al, 2003), and are less able to adjust decision-making to short-term versus long-term gains (Gonzalez et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Altered reward expectancy in individuals with recent methamphetamine dependence

et al. 2016

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Background Chronic methamphetamine use may lead to changes in reward-related function of the ventral striatum and caudate nucleus. Whether methamphetamine dependent individuals show heightened reactivity to positively valenced stimuli (i.e., positive reinforcement mechanisms), or an exaggerated response to negatively valenced stimuli (i.e., driven by negative reinforcement mechanisms) remains unclear. This study investigated neural functioning of expectancy and receipt for gains and losses in adults with (METH+) and without (METH−) histories of methamphetamine dependence. Methods Participants (17 METH+; 23 METH−) performed a probabilistic feedback expectancy task during blood-oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI). Participants were given visual cues probabilistically associated with monetary gain, loss, or neutral outcomes. General linear models examined the BOLD response to: (1) anticipation of gains and losses, and (2) gain and loss monetary outcomes. Results METH+ had less BOLD response to loss anticipation than METH− in the ventral striatum and posterior caudate. METH+ also showed more BOLD response to loss outcomes than to gain outcomes in the anterior and posterior caudate, whereas METH− did not show differential responses to the valence of outcomes. Discussion METH+ individuals showed attenuated neural response to anticipated gains and losses, but their response to loss outcomes was greater than to gain outcomes. A decreased response to loss anticipation, along with a greater response to loss outcomes, suggests an altered ability to evaluate future risks and benefits based upon prior experience, which may underlie suboptimal decision-making in METH+ individuals that increases the likelihood of risky behavior.

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Young adult stimulant users' increased striatal activation during uncertainty is related to impulsivity

Cited by 46 publications

References 28 publications

Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals

Neuropsychological profiling of impulsivity and compulsivity in cocaine dependent individuals

Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex

Altered reward expectancy in individuals with recent methamphetamine dependence

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