Young children with psychotic symptoms and risk for suicidal thoughts and behaviors: a research note

Sinclair-McBride, Keneisha; Morelli, Nicholas; Tembulkar, Sahil; Graber, Kelsey; Gonzalez–Heydrich, Joseph; D’Angelo, Eugene J.

doi:10.1186/s13104-018-3680-3

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…Furthermore, among the feature set we utilized were variables related to prodromal psychosis symptoms, which have been previously unstudied with respect to STBs in the ABCD sample. Importantly, there is a substantial body of literature demonstrating elevated levels of STBs among children and adolescents at high clinical risk for psychosis [ 45 , 46 ], highlighting the importance of including such variables in risk analyses. While it is tempting to over-interpret individual predictor importance, we advocate that these findings be considered in the context of the respective algorithm.…”

Section: Discussionmentioning

confidence: 99%

Prediction of suicidal ideation and attempt in 9 and 10 year-old children using transdiagnostic risk features

et al. 2021

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The objective of the current study was to build predictive models for suicidal ideation in a sample of children aged 9–10 using features previously implicated in risk among older adolescent and adult populations. This case-control analysis utilized baseline data from the Adolescent Brain and Cognitive Development (ABCD) Study, collected from 21 research sites across the United States (N = 11,369). Several regression and ensemble learning models were compared on their ability to classify individuals with suicidal ideation and/or attempt from healthy controls, as assessed by the Kiddie Schedule for Affective Disorders and Schizophrenia–Present and Lifetime Version. When comparing control participants (mean age: 9.92±0.62 years; 4944 girls [49%]) to participants with suicidal ideation (mean age: 9.89±0.63 years; 451 girls [40%]), both logistic regression with feature selection and elastic net without feature selection predicted suicidal ideation with an AUC of 0.70 (CI 95%: 0.70–0.71). The random forest with feature selection trained to predict suicidal ideation predicted a holdout set of children with a history of suicidal ideation and attempt (mean age: 9.96±0.62 years; 79 girls [41%]) from controls with an AUC of 0.77 (CI 95%: 0.76–0.77). Important features from these models included feelings of loneliness and worthlessness, impulsivity, prodromal psychosis symptoms, and behavioral problems. This investigation provided an unprecedented opportunity to identify suicide risk in youth. The use of machine learning to examine a large number of predictors spanning a variety of domains provides novel insight into transdiagnostic factors important for risk classification.

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Section: Discussionmentioning

confidence: 99%

Prediction of suicidal ideation and attempt in 9 and 10 year-old children using transdiagnostic risk features

et al. 2021

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“…These risk factors included caregiver social support, quality of the caregiver-child relationship, severity of the child's illness, and frequency of lifetime psychiatric hospitalizations. A dimensional model of psychosis was utilized to provide a better understanding of caregiver experiences, given the complexity of psychotic symptoms and an elevated risk for serious outcomes, such as suicide and self-injurious behavior in both PD and CHR-P populations (Sinclair-McBride et al, 2018). In addition, to our knowledge, no study has examined caregiver burden in caregivers of children with CHR-P.…”

Section: Present Studymentioning

confidence: 99%

“…CHR-P encompasses patients with a period of subthreshold positive symptoms, brief limited psychotic symptoms, or family history of psychosis, with a marked decline in psychosocial functioning (Fusar-Poli et al, 2013). CHR-P individuals experience impairments in social, academic, and occupational functioning as well as high rates of co-occurring psychiatric symptoms and suicidal thinking (Fusar-Poli et al, 2013, 2015; Sinclair-McBride et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Burden Experienced by Primary Caregivers of Children With Psychotic Disorders and at Clinical High Risk for Psychosis

Carroll

Wales

Rintell

et al. 2022

J Am Psychiatr Nurses Assoc

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Background: Despite the existing research exploring caregiver burden in adult psychosis, few studies have examined the experience of providing care to children diagnosed with psychotic disorders (PDs) and those identified as having clinical high risk for psychosis (CHR-P). Objective: This study measured the level of burden in caregivers of children with PD and CHR-P and examined associated risk factors, including social support, caregiver–child relationship, severity of illness, and frequency of psychiatric hospitalizations. Methods: A total of 56 caregivers completed validated measures and provided demographic information. Measures included the Zarit Burden Interview, the Multidimensional Scale of Perceived Social Support, the Behavior Assessment System for Children, Third Edition, Parenting Relationship Questionnaire–Child and Adolescent Form (BASC-3 PRQ-CA), and the Clinical Global Impression–Severity scale. Results: The majority of caregivers were women (86%), mothers (84%), White (63%), married (66%), working full-time (50%), college-educated (79%), and whose mean age was 45.7 years ( SD = 8.09). Nearly half of the caregivers (45%) reported a high level of caregiver burden, 39% rated their burden in the mild to moderate range, and 16% reported little to no burden. There was no significant difference in mean burden between PD and CHR-P groups. Higher caregiver burden was associated with lower levels of social support ( r = −.408, p = .002), lower levels of parenting confidence ( r = −.514, p < .001), higher levels of relational frustration ( r = .612, p < .001), and higher severity of illness ( r = .316 p = .025). Conclusions: These findings underscore the critical unmet need for support for caregivers of children with PD and CHR-P. Applications to clinical practice are discussed.

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“…According to Lincoln’s study, depressed children and adolescents have an estimated 30% suicidal behavior, which is significantly higher than their healthy peers [ 29 ]. Suicidal behavior was observed with greater frequency and severity in young adult patients, resulting in poorer outcomes [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-naïve patients with major depressive disorder

Wu,

Zhao,

et al. 2024

BMC Psychiatry

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Background Major depressive disorder (MDD) is a common psychiatric disorder worldwide. Psychotic depression has been reported to be frequently under-diagnosed due to poor recognition of psychotic features. Therefore, the purpose of this study was to reveal the rate and risk factors of psychotic symptoms in young, drug-naïve patients with major depressive disorder at the time of their first episode. Methods A total of 917 patients were recruited and divided into psychotic and non-psychotic subgroups based on the Positive and Negative Syndrome Scale (PANSS) positive subscale score. Anxiety symptoms and depressive symptoms were measured by the Hamilton Anxiety Rating Scale (HAMA) and the 17-item Hamilton Depression Rating Scale (HAMD-17), respectively. Several biochemical indicators such as total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4) were also measured. Results The rate of psychotic symptoms among young adult MDD patients was 9.1%. There were significant differences in TSH (p<0.001), FBG (p<0.001), TC (p<0.0001), TG (p = 0.001), HDL-C (p = 0.049), LDL-C (p = 0.010), diastolic blood pressure (DP) (p<0.001), systolic blood pressure (SP) (p<0.001), and HAMD total score (p<0.001) between young MDD patients with and without psychotic depression. HAMD, TSH, TC, and severe anxiety were independently associated with psychotic symptoms in young adult MDD patients. In addition, among young MDD patients, the rate of suicide attempts in the psychotic subgroup was much higher than in the non-psychotic subgroup (45.8% vs. 16.9%). Conclusions Our findings suggest that psychotic symptoms are common in young MDD patients. Several clinical variables and biochemical indicators are associated with the occurrence of psychotic symptoms in young MDD patients.

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Young children with psychotic symptoms and risk for suicidal thoughts and behaviors: a research note

Cited by 6 publications

References 24 publications

Prediction of suicidal ideation and attempt in 9 and 10 year-old children using transdiagnostic risk features

Prediction of suicidal ideation and attempt in 9 and 10 year-old children using transdiagnostic risk features

Burden Experienced by Primary Caregivers of Children With Psychotic Disorders and at Clinical High Risk for Psychosis

Prevalence and risk factors for psychotic symptoms in young, first-episode and drug-naïve patients with major depressive disorder

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