Young foal and adult horse monocyte-derived dendritic cells differ by their degree of phenotypic maturity

Mérant, Catherine; Breathnach, Cormac C.; Köhler, Katharina; Rashid, Cetewayo S.; Meter, Patricia Van; Horohov, David W.

doi:10.1016/j.vetimm.2009.03.002

Cited by 35 publications

(18 citation statements)

References 23 publications

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“…Recent studies have shown that monocyte-derived dendritic cells from foals are phenotypically different from those from adult horses, having decreased major histocompatibility complex class II and CD86 expression (5,17).…”

Section: Fig 3 Mean Concentrations Of Ifn-␥ (A) and Il-4 (B)mentioning

confidence: 99%

Equine Neonates Have Attenuated Humoral and Cell-Mediated Immune Responses to a Killed Adjuvanted Vaccine Compared to Adult Horses

Ryan

Giguère

2010

Clin Vaccine Immunol

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The objectives of this study were to compare relative vaccine-specific serum immunoglobulin concentrations, vaccine-specific lymphoproliferative responses, and cytokine profiles of proliferating lymphocytes between 3-day-old foals, 3-month-old foals, and adult horses after vaccination with a killed adjuvanted vaccine. Horses were vaccinated intramuscularly twice at 3-week intervals with a vaccine containing antigens from bovine viral respiratory pathogens to avoid interference from maternal antibody. Both groups of foals and adult horses responded to the vaccine with a significant increase in vaccine-specific IgGa and IgG(T) concentrations. In contrast, only adult horses and 3-month-old foals mounted significant vaccine-specific total IgG, IgGb, and IgM responses. Vaccine-specific concentrations of IgM and IgG(T) were significantly different between all groups, with the highest concentrations occurring in adult horses, followed by 3-month-old foals and, finally, 3-day-old foals. Only the adult horses mounted significant vaccine-specific lymphoproliferative responses. Baseline gamma interferon (IFN-␥) and interleukin-4 (IL-4) concentrations

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Section: Fig 3 Mean Concentrations Of Ifn-␥ (A) and Il-4 (B)mentioning

confidence: 99%

Equine Neonates Have Attenuated Humoral and Cell-Mediated Immune Responses to a Killed Adjuvanted Vaccine Compared to Adult Horses

Ryan

Giguère

2010

Clin Vaccine Immunol

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“…It should be emphasized that foals are very susceptible to infections by opportunistic pathogens such as A. fumigatus. This is thought to be because of the immaturity of their immune systems, especially their inability to produce interferon gamma [22,23]. Some authors demonstrated that very young dendritic cells are quantitatively less mature in foals than their adult counterparts.…”

Section: Discussionmentioning

confidence: 99%

Five Fatal Cases of Primary Pulmonary Aspergillosis in Albino Asinara Donkey Foals

Stefanetti

Marenzoni

Lepri

et al. 2015

Journal of Equine Veterinary Science

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“…Surface staining was performed on fresh isolated intestinal epithelial cells, as described previously. 19 Cells were labeled with primary antibodies (BD Pharmingen San Jose, CA) to CD3 + , CD4 + , CD8 + , CD56 + (NK cells), or an IgG1 isotype control (BD Pharmingen Sparks, NV) followed by fluorescent labeling with secondary antibodies anti-mouse IgG1 (Southern Biotechnology Associates, Birmingham, AL). The cells were then resuspended in fluorescence-activated cell sorting flow for acquisition and analyses using a FACSCalibur (BD, Franklin Lakes, NJ).…”

Section: Quantification Of Intestinal Epithelial T-cell Subsets and Nmentioning

confidence: 99%

Bacterial Translocation Contributes to Cachexia and Its Possible Pathway in Patients With Colon Cancer

Jiang¹,

Lin

Zhang³

et al. 2014

Journal of Clinical Gastroenterology

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Young foal and adult horse monocyte-derived dendritic cells differ by their degree of phenotypic maturity

Cited by 35 publications

References 23 publications

Equine Neonates Have Attenuated Humoral and Cell-Mediated Immune Responses to a Killed Adjuvanted Vaccine Compared to Adult Horses

Equine Neonates Have Attenuated Humoral and Cell-Mediated Immune Responses to a Killed Adjuvanted Vaccine Compared to Adult Horses

Five Fatal Cases of Primary Pulmonary Aspergillosis in Albino Asinara Donkey Foals

Bacterial Translocation Contributes to Cachexia and Its Possible Pathway in Patients With Colon Cancer

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