Young healthy adults with a family history of hypertension have increased microvascular reactivity but decreased macrovascular function

Matthews, Evan L.; Guers, John J.; Hosick, Peter A.

doi:10.1111/micc.12676

Cited by 6 publications

(2 citation statements)

References 60 publications

(157 reference statements)

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“…Brachial artery 47 [19,189,185,201,182,199,186,157,193,183,164,158,184,165,190,205,191,166,159,175,170,176,179,171,194,200,202,187,180,160,196,197,161,206,198,203,167,162,168,169,163,192,172,173,177,174,178] Femoral artery 2 [195,188] Posterior tibial artery 1 [204] Aspect of vasculature assessed Endothelial function 45…”

Section: Vascular Bed Assessedmentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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Research involving human subjects in ambulatory settings is a critical link in the chain comprising translational research, spanning preclinical research to human subject and patient cohort studies. There are presently a wide array of techniques and approaches available to investigators wishing to study blood flow, perfusion, and vascular structure and function in human subjects. In this multi-sectioned review, we discuss capillaroscopy, carotid intima-media thickness, flow-mediated dilation, laser Doppler flowmetry, near-infrared spectroscopy, peripheral arterial tonometry, pulse wave velocity, retinal fundus imaging, and vascular plethysmography. Each section contains a general overview and the physical basis of the technique followed by a discussion of the procedures involved and the necessary equipment, with attention paid to specific requirements or limitations. Subsequently, we detail which aspects of vascular function can be studied with a given technique, the analytical approach to the collected data, and the appropriate application and limitation(s) to the interpretation of the data collected. Finally, a modified scoping review provides a summary of how each assessment technique has been applied in previous studies. It is anticipated that this review will provide an efficient source of information and insight for preclinical investigators seeking to add translational aspects to their research programs.

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Section: Vascular Bed Assessedmentioning

confidence: 99%

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

et al. 2023

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“…1a). The area under the curve of the postischemic hyperemia phase (AUC-H) reflects the capillary recruitment in the observed tissues after ischemia [10].…”

Section: Introductionmentioning

confidence: 99%

The use of a vascular occlusion test combined with near-infrared spectroscopy in perioperative care: a systematic review

Niezen

Massari

Vos

et al. 2022

J Clin Monit Comput

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In the perioperative phase oxygen delivery and consumption can be influenced by different factors, i.e. type of surgery, anesthetic and cardiovascular drugs, or fluids. By combining near-infrared spectroscopy (NIRS) monitoring of regional tissue oxygen saturation (StO 2 ) with an ischemic provocation test, the vascular occlusion test (VOT), local tissue oxygen consumption and vascular reactivity at the microcirculatory level can be assessed. This systematic review aims to give an overview of the clinical information that VOT-derived NIRS values can provide in the perioperative period. After performing a systematic literature search, we included 29 articles. It was not possible to perform a meta-analysis because of the lack of comparable data and the observational nature of the majority of the included articles. We have clustered the found articles in two groups: non-cardiac surgery and cardiac surgery. We found that VOT-derived NIRS values show a wide variability and are influenced by the effects of anesthetics, cardiovascular drugs, fluids, and by the type of surgery. Additionally, deviations in VOT-derived NIRS values are also associated with adverse patients' outcomes, such as postoperative complications, prolonged mechanical ventilation and prolonged hospital length of stay. However, given the variability in VOT-derived NIRS values, clinical applicability remains elusive. Future clinical interventional trials might provide additional insight into the potential of VOT associated with NIRS to optimize perioperative care by targeting specific interventions to optimize the function of the microvasculature.

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Contributions to forearm desaturation during transient ischemia in healthy adult males and females across the lifespan

Perlet,

Traylor,

Ransom

et al. 2024

Appl. Physiol. Nutr. Metab.

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This study investigated skeletal muscle tissue oxygenation (StO2) desaturation in males and females across the adult lifespan. One-hundred-two individuals (51 females) of 41 young, 34 midlife, and 27 older adults completed a vascular occlusion test with near-infrared spectroscopy (NIRS+VOT). This included five minutes of arterial occlusion, inducing transient ischemia in the forearm flexor muscle group while recording StO2. The magnitude of desaturation (StO2mag) was quantified as the difference between baseline StO2 and the minimum StO2 value observed during ischemia. The rate of desaturation was also examined. Forearm adipose tissue thickness (ATT), forearm lean mass, and handgrip muscular strength were measured. A p ≤ 0.05 was considered significant. Two-way between factor ANOVAs indicated that males exhibited significantly (p<0.001) less ATT than females (collapsed across age) and that forearm lean mass (p<0.001) and muscular strength (p<0.001) decreased across the lifespan independent of sex. Bivariate analyses revealed significant (p<0.05) associations for sex, age, ATT, forearm lean mass, and muscular strength with the desaturation metrics. The ATT values demonstrated the strongest relations with StO2mag and desaturation rate (r = -0.620 and 0.618). Using a model comparison approach, ATT plus age offered the best predictive power for StO2mag and desaturation rate (R2 = 0.456 and 0.438) such that the inclusion of sex did not improve the models. These findings suggested differences in desaturation were primarily explained by variations in ATT and, to a lesser extent, age, but biological sex had no meaningful effect. Future studies must determine what other factors influence desaturation during ischemia.

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Young healthy adults with a family history of hypertension have increased microvascular reactivity but decreased macrovascular function

Cited by 6 publications

References 60 publications

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

Assessments of Perfusion, Blood Flow, and Vascular Structure in Ambulatory Subjects: Guidance for Translational Research Scientists

The use of a vascular occlusion test combined with near-infrared spectroscopy in perioperative care: a systematic review

Contributions to forearm desaturation during transient ischemia in healthy adult males and females across the lifespan

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