Young Infants with Recurrent Wheezing and Positive Asthma Predictive Index Have Higher Levels of Exhaled Nitric Oxide

Abstract

Infants with recurrent wheezing who had a positive stringent API already had higher FE(NO) levels than those with a negative API. This finding needs to be corroborated in a larger prospective study.

Childhood Asthma-Predictive Phenotype

“…81 Furthermore, 2 additional studies found an association of higher fractional exhaled nitric oxide levels in preschool children with recurrent wheezing and a positive API compared with those with a negative API. 107,108 Another study, which compared the lung function of 50 preschool children with recurrent wheezing and a positive or negative API, found that those with a positive API had significant lower lung function, maximal flow at functional residual capacity, in early life. 109 Asthma has a significant genetic contribution, with heritability estimates that vary between 35% and 95%.…”

Risk of herpes zoster in children with asthma

“…14 Because the API has only been used in prospective or cross-sectional studies, [15][16][17][18][19] not a retrospective study, we recently validated use of the API for a retrospective study. The API and PAC showed a high concordance rate (82.9%), and the API showed excellent construct validity in association with known risk factors for asthma, such as other atopic conditions, a family history of asthma, and lower parental education, which indicates suitability of using the API for a retrospective study.…”

Identification of infants and preschool children at risk for asthma

“…Cross-sectional studies [17][18][19] in wheezing infants and preschool children have found higher levels of FeNO among those with persistent symptoms, major risk factors for asthma (mainly atopy), and positive predictive scores. Although significant differences in FeNO were found between these groups, marked overlap of FeNO values can be observed and no cut-off could be established.…”