Young Persimmon Ingestion Suppresses Lipid Oxidation in Rats

Fushimi, Susumu; Miyazawa, Taiki; Kimura, Fumiko; Nakagawa, Kiyotaka; Burdeos, Gregor Carpentero; Miyazawa, Teruo

doi:10.3177/jnsv.61.90

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…Persimmon is a fruit that is known by its composition in nutritious and bioactive components, with a great potential for its use within the cosmetic and pharmaceutical industries [9,56,57,58,59,60,61,62]. This study and previous ones described persimmons as a fruit rich in PCs, such as gallic acid [63] and flavonoids [64].…”

Section: Discussionmentioning

confidence: 79%

Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability

et al. 2019

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Persimmon (Diospyros kaki L.), a fruit rich in phenolic compounds (PCs), has been considered effective in mitigating oxidative damage induced by an excess of reactive oxygen species. Due to large molecular weight and intrinsic instability in some physiological fluids, PCs’ passage through biological membranes is very limited. Carriers like phytosomes are promising systems to optimize oral absorption of encapsulated extracts. This work prepared and fully characterized phytosomes containing bioactive phenolic extracts from persimmon in terms of size, surface charge, encapsulation efficiency and stability over six months. These phytosomes were orally dosed to Wistar rats during a 15-day period. Afterwards, haematological and biochemical analyses were performed. Monodisperse phytosomes were successfully prepared, with size less than 300nm (PI < 0.3) and high encapsulation efficiency (97.4%) of PCs. In contrast to free extract, extract-loaded phytosomes had higher antioxidant activity after 6 months storage. Oral administration of extract-loaded phytosomes and free extract did not lead to lipidic profile changes and were within referenced normal ranges, as well as glycaemia levels and urine parameters. The results highlighted the potential of persimmon PCs as food supplements or pharmacological tools, suggesting a promising and safe phytosomal formulation containing bioactive agents of persimmon that could lead to health benefits.

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Section: Discussionmentioning

confidence: 79%

Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability

et al. 2019

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“…Fushimi et al () have investigated the antioxidant effects of unripe and mature persimmon in rats. Results showed that plasma phosphatidylcholine hydroperoxide levels, a biomarker of membrane lipid peroxidation, were significantly lower in the unripe persimmon group than in the control group, while no significant difference was observed between the mature persimmon group and the control group.…”

Section: Introductionmentioning

confidence: 99%

“…Results showed that plasma phosphatidylcholine hydroperoxide levels, a biomarker of membrane lipid peroxidation, were significantly lower in the unripe persimmon group than in the control group, while no significant difference was observed between the mature persimmon group and the control group. The authors suggested that soluble tannins, found more in unripe fruits, could contribute to the difference in the antioxidant effect observed (Fushimi et al, ). A few years earlier, another study had shown that several proanthocyanidin‐type dimers, from peanut skins and persimmon pulp, possess high dose‐dependent antioxidant potency.…”

Section: Introductionmentioning

confidence: 99%

Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects

Smeriglio

Barreca

Bellocco

et al. 2016

British J Pharmacology

511

363

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“…По итогам было установлено, что у крыс, употребляющих молодую хурму, сильнее, чем у других упал уровень гидропероксидов фосфолипидов в плазме, что тормозило развитие атеросклероза. Зрелая хурма тоже показала снижение гидропероксидов, но немного в меньшей степени [17] .  Экстракт листьев хурмы помогает при гипергликемии, гиперлипидемии и жировом гепатозе печени при диабете 2-го типа.…”

Section: в научных исследованияхunclassified

Хурма (лат. Diōspyros)

Елисеева Татьяна,

Ямпольский Алексей

2019

ЖЗПД

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В статье рассмотрены основные свойства хурмы и её воздействие на организм человека. Проведен систематический обзор современной специализированной литературы и актуальных научных данных. Указан химический состав и пищевая ценность фрукта, рассмотрено использование хурмы в различных видах медицины и эффективность её применения при различных заболеваниях. Отдельно проанализированы потенциально неблагоприятные эффекты хурмы на организм человека при определенных медицинских состояниях и заболеваниях. Рассмотрены научные основы диет с её применением. Расширенная HTML версия статьи приведена на сайте edaplus.info.

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Young Persimmon Ingestion Suppresses Lipid Oxidation in Rats

Cited by 7 publications

References 27 publications

Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability

Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability

Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects

Хурма (лат. Diōspyros)

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