Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

García-Berrocal, José Ramón; Diego, B. De; Fidalgo, Amaya Roldán; Yebra-Bango, M; Millán, Isabel; Trinidad, Almudena; Ramírez‐Camacho, Rafael

doi:10.1017/s0022215112002769

Cited by 5 publications

(4 citation statements)

References 19 publications

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“…Screening by title and abstract excluded 573 articles. A full-text review of remaining studies further eliminated 18 articles, leaving a total of 17 articles 6–8,10,11,17–28 for inclusion in the final analysis. A diagram outlining the summary of the search process is shown in Supplementary Figure S1.…”

Section: Resultsmentioning

confidence: 99%

“…Only studies that provided sufficient data on audiological outcomes of interest were included in the meta-analysis. Of the 17 studies, 14 studies 6–8,10,17,19–21,23–28 were used to analyze the risk of HL in patients with SLE, nine studies 6,8,11,17,19,22,24,27,28 were used to pool frequency-specific air- and bone-conduction PTT data, and two studies 8,24 were used to compare the serological and clinical profiles of patients with SLE with and without HL.…”

Section: Resultsmentioning

confidence: 99%

“…followed subjects in both groups with audiological evaluations for 10 years, no evidence of progressive HL was observed in the case cohort. 19 Six of the remaining studies 6,10,17,21,24,27 observed middle- and high-frequency SNHL among their patient cohort with SLE. As suggested by Andonopoulos et al.…”

Section: Discussionmentioning

confidence: 99%

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Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Yuen

Fried

Nguyen

et al. 2021

Lupus

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Objective To determine the prevalence of hearing loss (HL) in patients with systemic lupus erythematosus (SLE), describe frequency-specific hearing threshold changes in this patient population as compared to age-matched control, and compare the clinical and serological profiles of patients with SLE with and without HL. Methods A systematic review querying four databases (PubMed, Web of Science, Scopus, and Cochrane) was performed. Meta-analysis of available data was performed to determine the overall prevalence and odds ratio (OR) of HL, and compare mean differences in frequency-specific hearing thresholds between patients with SLE and control. Additionally, meta-analysis of proportions allowed for comparison of disease features present in patients with SLE with and without sensorineural HL. Results This review included 17 studies reporting on 1326 patients (635 with SLE and 691 control). The pooled prevalence of HL in patients with SLE was 27%. In comparison to control, patients with SLE had a significantly higher odds of HL (OR 14.6, 95% CI: 8.5 to 25.0). Mean air-conduction hearing thresholds in patients with SLE were significantly elevated relative to control at 125 and 250 Hz. Mean bone-conduction hearing thresholds were significantly elevated in patients with SLE across all measured frequencies except at 3000 and 6000 Hz compared to control. Disease features did not significantly differ between patients with SLE with and without HL. Conclusion Compared to age-matched control, patients with SLE have increased odds of HL, which primarily manifests at low frequencies. Therefore, this patient population requires greater audiologic attention.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Yuen

Fried

Nguyen

et al. 2021

Lupus

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“…Roverano et al recommended audiometric tests as part of initial studies in all SLE patients, because more than 60% of them have asymptomatic sensorineural hearing loss (6). But García‐Berrocal et al reported no evidence of progressive hearing loss in SLE patients who did not describe hearing loss at the beginning of the study; therefore, García‐Berrocal et al recommend audiometric tests only for SLE patients who describe hearing loss (7). …”

Section: Introductionmentioning

confidence: 99%

Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus

Kariya¹,

Kaya

Hızlı

et al. 2016

Otology &Amp; Neurotology

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Hypothesis We hypothesized that, in archived human temporal bone samples from patients with systemic lupus erythematosus (SLE), a pathologic condition exists in the stria vascularis and cochlear hair cells. Background Sensorineural hearing loss is a common feature in SLE patients. However, the pathophysiologic mechanism of cochlear dysfunction is unclear. Methods We examined 15 temporal bone samples from 8 SLE patients, along with 17 samples from 10 age-matched healthy control patients. The samples were serially sectioned in the horizontal plane and stained with hematoxylin and eosin. We determined the area of the stria vascularis in a midmodiolar section of each cochlear turn. Then, we made cytocochleograms and calculated the percentage of missing inner and outer hair cells. Results The area of the stria vascularis in our SLE group was significantly smaller than in our control group. The number of remaining inner hair cells in our SLE group was smaller than in our control group; however, the difference did not reach statistical significance. The loss of outer hair cells in our SLE group was significantly higher than in our control group. There was a tendency toward a positive correlation between the loss of cochlear hair cells and the duration of SLE. Conclusion The stria vascularis and cochlear hair cells are affected in SLE patients. Our findings could provide the histopathologic basis for the cochlear dysfunction, including sensorineural hearing loss, experienced by SLE patients.

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Extended high frequency audiometry can diagnose sub-clinic involvement in a seemingly normal hearing systemic lupus erythematosus population

Vega

Villarreal

Moya

et al. 2016

Acta Oto-Laryngologica

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Young systemic lupus erythematosus patients with no hearing involvement: 10-year follow up

Cited by 5 publications

References 19 publications

Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Hearing loss in patients with systemic lupus erythematosus: A systematic review and meta-analysis

Cochlear Histopathologic Findings in Patients With Systemic Lupus Erythematosus

Extended high frequency audiometry can diagnose sub-clinic involvement in a seemingly normal hearing systemic lupus erythematosus population

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