Young Tech-Entrep r e n e u r S   A g i l i t y   A n d   C o m p e t i t i v e n e s s

Halim, Hasliza Abdul; Ahmad, Noor Hazlina; Iqbal, Qaisar; Kee, Daisy Mui Hung

doi:10.15405/epsbs.2020.10.28

Cited by 13 publications

(15 citation statements)

References 22 publications

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“…Other changes in the spectral profile of mono-and poly/saccharides can be followed by IR bands at 1031/1153 cm −1 and 1012/1054 cm −1 that are assigned to the deformations of the COH groups and stretches of the COC groups (Table 1) [21,[43][44][45]. We summed up intensities of the 1031 and 1153 cm −1 bands and the 1012 and 1054 cm −1 bands, because their individual trends in the cancer progression were similar (data not shown while this trend can also be observed in the second derivative IR spectra in Figure 3C), and we assumed that they represent the same groups of biomolecules.…”

Section: Resultsmentioning

confidence: 99%

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

Blat

Wiercigroch

Smęda

et al. 2019

Journal of Biophotonics

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Despite advanced diagnostic techniques used for detecting cancer, this disease still remains a leading cause of death in the developed world. What is more, the greatest danger for patients is not related with growing of tumor but rather with metastasis of cancer cells to the distant organs. In this study, Fourier transform infrared (FTIR) spectroscopy was used to track chemical changes in blood plasma to find spectral markers of metastatic breast cancer during the disease progression. Plasma samples were taken 1‐5 weeks after orthotropic inoculation of 4T1 metastatic breast cancer cells to mice. The earliest changes detected by FTIR spectroscopy in plasma were correlated with unsaturation of phospholipids and secondary structures of proteins that appeared 2 and 3 weeks, respectively, after 4T1 cells inoculation (micrometastatic phase). Significant alternations in the content and structure of lipids and carbohydrates were identified in plasma at the later stages (macrometastatic phase). When large primary tumors in breast and macrometastases in lung were developed, all bands in FTIR spectra significantly differed from those at earlier phases of the cancer progression. In conclusion, we showed that each phase of the breast cancer progression and its pulmonary metastasis can be characterized by a specific panel of spectral markers.

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Section: Resultsmentioning

confidence: 99%

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

Blat

Wiercigroch

Smęda

et al. 2019

Journal of Biophotonics

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“…A number of MDEs such as urokinase plasminogen activator (uPA) and matrix metalloproteinases (MMPs) have been described [24]. Regulation of matrix-degrading activity is highly complex; no MDE is completely specific for one element of the ECM, and both uPA and MMPs have played a role in the necessary steps of tumour metastasis [24,[28][29][30][31][32][33][34][35][36][37][38].…”

Section: Solid Tumour Growth and Spreadmentioning

confidence: 99%

Calibrating models of cancer invasion: parameter estimation using approximate Bayesian computation and gradient matching

2021

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We present two different methods to estimate parameters within a partial differential equation model of cancer invasion. The model describes the spatio-temporal evolution of three variables—tumour cell density, extracellular matrix density and matrix degrading enzyme concentration—in a one-dimensional tissue domain. The first method is a likelihood-free approach associated with approximate Bayesian computation; the second is a two-stage gradient matching method based on smoothing the data with a generalized additive model (GAM) and matching gradients from the GAM to those from the model. Both methods performed well on simulated data. To increase realism, additionally we tested the gradient matching scheme with simulated measurement error and found that the ability to estimate some model parameters deteriorated rapidly as measurement error increased.

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“…UPR has several applications and is a common matrix in the production of composites, 23 which have been reinforced with natural fibers like jute, kenaf, sisal, bamboo, pineapple leaves, coconut and sugarcane bagasse, and their physical and mechanical properties were studied 24–29 . In recent years, similar composites from post‐consumer PET reinforced with treated natural fibers, such as rice husk, 30 kenaf, 31 coconut, 32 and acacia 33 were fabricated. Fiber content, fiber surface treatment, and fiber length effect on the physical and mechanical properties of the composites were studied.…”

Section: Introductionmentioning

confidence: 99%

Physical and mechanical properties of unsaturated polyester resin matrix from recycled PET (based PG) with corn straw fiber

García

Sánchez

Ortiz

et al. 2021

J of Applied Polymer Sci

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In this study, composites of unsaturated polyester resin (UPR), synthesized from recycled polyethylene terephthalate (PET), with 10 to 40% in volume of corn straw fiber (CSF), were elaborated and studied the effect of fiber content on their physical and mechanical properties. The content of cellulose (48.97%), hemicellulose (24.06%), and lignin (6.59%) were determined by chemical characterization of CSF. The characteristic bonds of the UPR were identified as a cross‐linking network between the styrene monomer (ST) and the unsaturated polyester (UP) through FTIR. Two decomposition stages were observed by TGA–DTG. The results of physical and mechanical properties showed that as the fiber content increased in the UPR, the water absorption increased (0.6% to 2.56%), on the other hand, the density (1218.23 to 1150.28 kg/m3), flexural strength (50.58 to 26.98 MPa), flexural modulus (2.66 to 2.29 GPa), tensile strength (8.62 to 3.65 MPa), tensile modulus (1.18 to 0.43 GPa), and hardness (81.67 to 65.67 Shore D), they decreased. SEM analysis showed some defects in the fiber distribution in the UPR, which affected the mechanical properties of the composites. This research contributes to the development of new material from use of two waste materials for the benefit of the environment.

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Young Tech-Entrep r e n e u r S A g i l i t y A n d C o m p e t i t i v e n e s s

Abstract: This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cited by 13 publications

References 22 publications

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

Fourier transform infrared spectroscopic signature of blood plasma in the progression of breast cancer with simultaneous metastasis to lungs

Calibrating models of cancer invasion: parameter estimation using approximate Bayesian computation and gradient matching

Physical and mechanical properties of unsaturated polyester resin matrix from recycled PET (based PG) with corn straw fiber

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