Yucatec Mayan medicinal plants: evaluation based on indigenous uses

Ankli, Anita; Heinrich, Michael; Bork, Peter M.; Wolfram, Lutz; Bauerfeind, Peter; Brun, Reto; Schmid, Caecilia; Weiss, Claudia; Bruggisser, Regina; Gertsch, Jürg; Wasescha, Michael; Sticher, Otto

doi:10.1016/s0378-8741(01)00355-5

Cited by 104 publications

(61 citation statements)

References 21 publications

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“…CarbaOZ277 (1,3-dioxolane) was prepared as a mixture of cis-trans isomers by an acidcatalyzed reaction (9) between the requisite adamantane diol and amino amide cyclohexanone. In vitro antiprotozoal assays for Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, Giardia duodenalis, Babesia divergens, and Neospora caninum were performed as previously described (1,5,16,28,35,38,40) with standard drug controls ( Table 1).The data in Table 1 shows a clear demarcation in the antiplasmodial activities of artemisinin and OZ277 versus their nonperoxidic analogs deoxyartemisinin (6) and carbaOZ277, confirming the peroxide bond-dependent activity of the former. For artemisinin and OZ277, there were losses of activity greater than 3 orders of magnitude against all of the other protozoa compared to activities against P. falciparum.…”

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confidence: 99%

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Kaiser

Wittlin

Nehrbass-Stuedli

et al. 2007

Antimicrob Agents Chemother

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Using nonperoxidic analogs of artemisinin and OZ277 (RBx11160), the strong in vitro antiplasmodial activities of the latter two compounds were shown to be peroxide bond dependent. In contrast, the weak activities of artemisinin and OZ277 against six other protozoan parasites were peroxide bond independent. These data support the iron-dependent artemisinin alkylation hypothesis.The antimalarial artemisinin contains a pharmacophoric peroxide bond within its 1,2,4-trioxane heterocycle. A longstanding hypothesis (17,24,29) to account for the antimalarial specificity of artemisinin is that the peroxide bond undergoes reductive activation by heme released by parasite hemoglobin (Hb) digestion. Although most (95%) of the heme released from parasite digestion is incorporated into the relatively inert hemozoin (12), it is estimated (8) that there is some 100 M of "free" heme/hematin in malaria-infected red blood cells, a more than adequate quantity to react with artemisinin. The irreversible redox reaction between artemisinin and heme produces carbon-centered free radicals or carbocations that alkylate heme (25,32,33) and membrane-associated parasite proteins (2), one of which is the translationally controlled tumor protein (PfTCTP) (4) and another is likely to be PfATP6, a SERCA-type Ca 2ϩ -ATPase (11). Eckstein-Ludwig et al. (11) studied the latter protein in some detail and provided evidence that it may be an important target of the artemisinins.The structural diversity of semisynthetic artemisinins (41) and synthetic peroxides (37) is quite remarkable and, we suggest, has implications for the mechanism of action for this class of antimalarial drugs. In this respect, we thought it might be useful to compare the activities of artemisinin and synthetic peroxide (1,2,4-trioxolane) OZ277 (RBx11160) (40) and their nonperoxidic counterparts deoxyartemisinin (6) and carbaOZ277 (Fig. 1) against a range of protozoan parasites. CarbaOZ277 (1,3-dioxolane) was prepared as a mixture of cis-trans isomers by an acidcatalyzed reaction (9) between the requisite adamantane diol and amino amide cyclohexanone. In vitro antiprotozoal assays for Plasmodium falciparum, Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, Giardia duodenalis, Babesia divergens, and Neospora caninum were performed as previously described (1,5,16,28,35,38,40) with standard drug controls ( Table 1).The data in Table 1 shows a clear demarcation in the antiplasmodial activities of artemisinin and OZ277 versus their nonperoxidic analogs deoxyartemisinin (6) and carbaOZ277, confirming the peroxide bond-dependent activity of the former. For artemisinin and OZ277, there were losses of activity greater than 3 orders of magnitude against all of the other protozoa compared to activities against P. falciparum. In contrast, for deoxyartemisinin and carbaOZ277, there were only small differences in activity between P. falciparum and the other protozoa. Only for T. b. rhodesiense was there a significant difference between artemisinin and deoxyartemisinin ve...

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mentioning

confidence: 99%

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Kaiser

Wittlin

Nehrbass-Stuedli

et al. 2007

Antimicrob Agents Chemother

Self Cite

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“…Among others, aqueous extracts of 8% onion (Allium cepa) and ≥ 4% marigold (Tagetes sp) inhibited 73% and 79% of F. oxisporum growth, respectively [38]. In addition, organic extracts of Diospyros cuneata have been tested on Candida albicans, a human pathogenic fungi, and results have shown that Diospyros cuneata can reduce fungal growth [9]. However, no information has yet been reported about the antifungal properties of aqueous extracts of D. cuneata as we have reported here.…”

Section: Resultsmentioning

confidence: 99%

“…Diospyros cuneata and D. anisandra have been reported ethnobotanically to have medicinal properties that can be used to treat dermatological problems. Organic extracts of these plants have been tested on human fungal and bacterial pathogens [9]. Conversely, there is currently no information regarding the antifungal activity of aqueous extracts of Diospyros cuneata for combating crop pathogens such as Fusarium oxysporum.…”

Section: Introductionmentioning

confidence: 99%

Diospyros cuneata Inhibition of Fusarium oxysporum: Aqueous Extract and its Encapsulation by Ionic Gelation

Jc¹,

Peraza-Echeverrı́a²,

Rm³

et al. 2016

J Plant Pathol Microbiol

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“…The use of natural products from the extracts of medicinal plants in the treatment of skin, respiratory, neuromuscular and mental health disorders and also in obstetrics and gynecology is already known [17][18][19]. The potential anti-tumor activity of the medicinal plants has been recently described in many studies [20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Thyme essential oil inhibits proliferation of DLD-1 colorectal cancer cells through antioxidant effect

Çetinus¹,

Temiz²,

Ergül³

et al. 2013

CMJ

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Aim. It is a very hot topic to investigate the effects and the mechanisms of action of biological active extracts such as thyme essential oil on various cancer cells. This paper examines the ability of thyme essential oil to inhibit the growth of DLD-1 colorectal cancer cells and if it is the case, determine the contribution of antioxidant effect to this ability. Methods. To do this, we treated human DLD-1 colorectal cancer cells with thyme essential oil and assessed its effects on cell proliferation by using real time cell analyzing system (Xcelligence System). Furthermore, we applied the same concentrations to the L929 fibroblast cells in order to determine if thyme essential oil has cytotoxicity on normal cells in the same concentrations it showed anticancer effects. Then, antioxidant ability of thyme essential oil was evaluated by using DPPH assay. Results. Thyme essential oil treated DLD-1 cells exhibited decreasing cell index values in a concentration-dependent manner. An inhibitor concentration 50 (IC 50 ) value of 0.347 mg/mL was achieved. On the other hand, when thyme essential oil was tested on L929 fibroblast cells, it was observed that thyme essential oil did not show cytotoxic effect on L929 fibroblast cells. IC 50 value was 22 mg/mL for this experiment. Besides, thyme essential oil showed a strong antioxidant effect on DPPH assay. Conclusion. When the antiproliferative and the antioxidant effects of thyme essential oil are considered, it can be concluded that thyme essential oil may be an alternative option in the treatment of colorectal cancer.

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Yucatec Mayan medicinal plants: evaluation based on indigenous uses

Cited by 104 publications

References 21 publications

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Peroxide Bond-Dependent Antiplasmodial Specificity of Artemisinin and OZ277 (RBx11160)

Diospyros cuneata Inhibition of Fusarium oxysporum: Aqueous Extract and its Encapsulation by Ionic Gelation

Thyme essential oil inhibits proliferation of DLD-1 colorectal cancer cells through antioxidant effect

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