Yüksek nötrofil- lenfosit oranının renal hücreli karsinomda preoperatif ve postoperatif dönemde sağkalıma etkisi

Abstract

ÖZObjective: The neutrophil-lymhocyte ratio (NLR) has been used as a marker of systemic inflammatory response and various studies confirmed it affects overall survival in renal cell carcinom (RCC). Most studies used NLR as a poor prognostic factor when assesed preoperatively. The aim of our study is to demonstrate the postoperative NLR as a poor prognostic factor. Material and Methods:We reviewed 135 patients with RCC who were treated and followed in Kocaeli Univercity Medical Oncology Department between 2003 and 2014. Overall survival and progression free survival were assesed by using KaplanMaier method and prognostic significance of NLR and other independent factors were assesed by using cox regression models.Results: Univariate and multivariate analyses showed that T stage (HR:1.86; 95% Cl:1.2-2.5 p:0.003), hemoglobin count (HR:0.51; 95% Cl:0.34-0.76 p:0.001) and NLR (HR: 2.6; 95% Cl:1.1-5.5 p:0.017) as independent prognostic factors for overall survival. Conclusion: An increased NLR even after partial or radical nephrectomy can be a prognostic marker for RCC. In addition to recent studies which found preoperative NLR is a poor prognostic factor in RCC, we found postoperative NLR has a significance in overall survival.