Yunnanterpene G, a spiro-triterpene from the roots of Cimicifuga foetida, downregulates the expression of CD147 and MMPs in PMA differentiated THP-1 cells

Abstract

Yunnanterpene G (1), a new cycloartane triterpene with an oxaspiro[5.4]decane moiety, was purified from the roots of Cimicifuga foetida. Significantly, it downregulates the expression of CD147 and MMPs in PMA differentiated THP-1 cells.

New triterpenes from Cimicifuga yunnanensis down-regulating the mRNA expression of CD147, MMP-2, and MMP-9

“… 19,20 Recently, we identified two CTs, yunnanterpene G (YG) and 12β-hydroxycimiacerol (HC), with anti-atherosclerosis potentials by potently suppressing the mRNA expressions of CD147 and MMPs. 21,22 As a part of our successive program to explore bioactive CTs from Cimicifuga spp, nine unreported CTs glycosides (1–6, 9, and 11–12) and two new aglycones (7 and 8), together with one undescribed lanostane-type triterpene (10) were identified from the aerial parts of C. yunnanensis ( Fig. 1 ), an indigenous species distributed in the southwest region of China.…”