YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells

Wang, Jia; Wu, Xingui; Wei, Chao; Huang, Xin; Ma, Qian; Huang, Xiaona; Faiola, Francesco; Guallar, Diana; Fidalgo, Miguel; Huang, Tuo; Peng, Di; Chen, Li; Yu, Haopeng; Li, Xingyu; Sun, Junyi; Liu, Xinyi; Cai, Xiaoyan; Chen, Xiao; Wang, Ling; Ren, Jian; Wang, Jianlong; Ding, Junjun

doi:10.1016/j.stemcr.2018.02.004

Cited by 60 publications

(44 citation statements)

References 54 publications

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“…YY1 is a ubiquitously distributed transcription factor belonging to the class of zinc finger proteins involved in repressing and activating a diverse number of promoters and enhancers. YY1 also directs histone deacetylases and histone acetyltransferases to promoter regions in order to activate or repress the promoter, thus implicating histone modification also in the function of YY1 (Wang et al, ). YY1 was first described in a 3 year old male from nonconsanguineous parents containing a missense mutation (c.1138G > T, p.Asp380Tyr) with intrauterine growth retardation with delayed motor development, moderate intellectual disability, and dysmorphic features (Vissers et al, ).…”

Section: Discussionmentioning

confidence: 99%

A case of YY1‐associated syndromic learning disability or Gabriele‐de Vries syndrome with myasthenia gravis

Morales‐Rosado

Kaiwar

Smith

et al. 2018

American J of Med Genetics Pt A

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Exome sequencing is being used increasingly to evaluate patients with intellectual disability. YY1 is a ubiquitously distributed transcription factor belonging to the GLIKruppel class of zinc finger proteins recently recognized as the causative gene in 23 patients for the Gabriele-de Vries syndrome. We report a new case with similar features and a novel variant in YY1, in a region of the gene, which has not previously been reported. A 25 year old female was referred to clinical genetics with a diagnosis of autoimmune myasthenia gravis, facial dysmorphism and learning disability. Chromosomal microarray and gene panel test for congenital myasthenic syndrome was negative. Whole exome sequencing (WES) revealed a presumed pathogenic de novo novel, heterozygous, truncating variant in the YY1 gene, c.860_864delTTAAAA, p.Ile287Argfs*3. The Ile287 residue is conserved across species and is situated in the transcription repressor domain of the protein. This variant is novel and lies in a domain of the protein where no previously reported variants occur. The phenotypic features of our case closely match those of the reported patients. Autoimmune myasthenia gravis has not been reported in these patients and may constitute an expansion of this phenotypic spectrum or perhaps more likely a second unrelated diagnosis. K E Y W O R D S Gabriele-de Vries, learning disability, myasthenia gravis, yin and Yang 1, YY1

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Section: Discussionmentioning

confidence: 99%

A case of YY1‐associated syndromic learning disability or Gabriele‐de Vries syndrome with myasthenia gravis

Morales‐Rosado

Kaiwar

Smith

et al. 2018

American J of Med Genetics Pt A

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“…Zbtb18 regulates cell-cycle exit of neural progenitors during embryonic cortical neurogenesis (Okado, 2019). Yy1 regulates proliferation of many stem cells, including embryonic stem cells (Wang et al, 2018), cardiac progenitor cells (Gregoire et al, 2017), intestinal stem cells (Perekatt et al, 2014), hematopoietic stem cells (Lu et al, 2018), and neu-ral progenitors (Knauss et al, 2018). Similar motif analysis of peaks found in mature dentate gyrus, but not in neural progenitors, identified two top binding site motifs shared by a number of transcription factors (Figures 6E and 6G).…”

Section: Atac-seq Analysis Of Dentate Hopx + Progenitors Across Develmentioning

confidence: 99%

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Berg

Jimenez-Cyrus

et al. 2019

Cell

221

273

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Graphical AbstractHighlights d The Hopx-CreER T2 line can label an embryonic origin of adult dentate neural progenitors d Hopx + dentate progenitors exhibit constant lineage specification across development d Developmental and adult dentate neurogenesis are one continuous process d Hopx + dentate progenitors retain common molecular signatures across development SUMMARY New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx + precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to proliferative Hopx + neural progenitors in the primitive dentate region, and they, in turn, generate granule neurons, but not other neurons, throughout development and then transition into Hopx + quiescent radial glial-like neural progenitors during an early postnatal period. RNA-seq and ATAC-seq analyses of Hopx + embryonic, early postnatal, and adult dentate neural progenitors further reveal common molecular and epigenetic signatures and developmental dynamics. Together, our findings support a ''continuous'' model wherein a common neural progenitor population exclusively contributes to dentate neurogenesis throughout development and adulthood. Adult dentate neurogenesis may therefore represent a lifelong extension of development that maintains heightened plasticity in the mammalian hippocampus.

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“…YY1 could globally mediate enhancer‐promoter interactions by binding to DNA and facilitate the formation of chromatin loops, probably through its dimerization . In addition, YY1 has been further indicated to positively regulate transcription by targeting promoters and enhancers to through the BAF complexes in embryonic stem cells …”

Section: Role and Advance On Transcription Reserchesmentioning

confidence: 99%

Enhancer and super‐enhancer: Positive regulators in gene transcription

Peng

Zhang

2018

Anim Models and Exp Med

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Enhancer is a positive regulator for spatiotemporal development in eukaryotes. As a cluster, super‐enhancer is closely related to cell identity‐ and fate‐determined processes. Both of them function tightly depending on their targeted transcription factors, cofactors, and genes through distal genomic interactions. They have been recognized as critical components and played positive roles in transcriptional regulatory network or factory. Recent advances of next‐generation sequencing have dramatically expanded our ability and knowledge to interrogate the molecular mechanism of enhancer and super‐enhancer for transcription. Here, we review the history, importance, advances and challenges on enhancer and super‐enhancer field. This will benefit our understanding of their function mechanism for transcription underlying precise gene expression.

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YY1 Positively Regulates Transcription by Targeting Promoters and Super-Enhancers through the BAF Complex in Embryonic Stem Cells

Cited by 60 publications

References 54 publications

A case of YY1‐associated syndromic learning disability or Gabriele‐de Vries syndrome with myasthenia gravis

A case of YY1‐associated syndromic learning disability or Gabriele‐de Vries syndrome with myasthenia gravis

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Enhancer and super‐enhancer: Positive regulators in gene transcription

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