Z-Butylidenephtalide in the Essential Oil from Roots of Levisticum officinale

Gijbels, M. J. M.; Scheffer, J. J. C.; Svendsen, A. Baerheim

doi:10.1055/s-2008-1075000

Cited by 16 publications

(10 citation statements)

References 8 publications

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“…1). ted from the oil by preparative GLC in a previous study, which dealt with the stereo-chemistry of Eand Z-butylidenephthalide [12]. Then the E-isomer could not be detected in the oil of L. officinale roots.…”

Section: Resultsmentioning

confidence: 94%

Phthalides in the Essential Oil from Roots ofLevisticum officinale*

Gijbels¹,

Scheffer²,

Svendsen³

1982

Planta Med

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The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustilide, senkyunolide and validene-4,5-dihydrophthalide were found to be present; isosenkyunolide and propylidenephthalide were tentatively identified. The influence of the isolation procedure on the composition of the phthalide mixture was tentatively studied by comparison of mixtures isolated by solvent extraction and hydrodistillation respectively.

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Section: Resultsmentioning

confidence: 94%

Phthalides in the Essential Oil from Roots ofLevisticum officinale*

Gijbels¹,

Scheffer²,

Svendsen³

1982

Planta Med

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“…1. Different numbering systems are in use; we adhere to the oldest system (1,2). The compounds with saturated side chains are depicted as having the (S)-configuration at C-3, as all natural phthalides for which the absolute configuration has been determined have that configuration (1).…”

Section: Resultsmentioning

confidence: 99%

“…(Z)-and (E)-Butylidenephthalides were obtained as a mixture by means of a Perkin reaction (2) and separated by LSC and preparative GC. Their identity to the natural compounds (present in Levisticum officinale) was proven using, among others, GC-MS. Butylphthalide was during the separation of the root extract of Cnidium officinale (see above).…”

Section: Methodsmentioning

confidence: 99%

cis- andtrans-Neocnidilide;¹H- and¹³C-NMR Data of Some Phthalides

Fischer

Gijbels²

1987

Planta Med

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“…Le spectre de masse du compose naturel (1) Le rhizome de L. wallichii (1,3 kg) est epuisé, a temperature ambiante, au chloroforme (20 I) apres degraissage a ! 'hexane (20 I).…”

Section: Résultats Et Discussionunclassified