Z-scores of early diastolic blood flow widths of mitral and tricuspid valves in normal fetuses and fetuses with dilated coronary sinus

Luo, Jieting; Zhao, Bowen; Pan, Mingzhang; Wang, Bei; Peng, Xiaohui; Chen, Ran; Xiong, Li

doi:10.1080/14767058.2018.1523894

Cited by 4 publications

(1 citation statement)

References 23 publications

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“…Observations in the echocardiogram studies were subject to the interpretation of the original observers, including the degree of left ventricular hypoplasia. While z-scores allow for the normalization of measurements to GA, their use has known limitations [ 7 , 23 , 24 ]. Surgical recommendations were determined after birth, with candidacy for BVR subject to the interpretation of cardiologist and surgeon.…”

Section: Discussionmentioning

confidence: 99%

Mitral valve abnormalities associated with single-ventricle palliation, cardiac death or transplant in fetuses with postnatally confirmed coarctation of the aorta

Foy,

Soslow,

Kavanaugh-McHugh

et al. 2023

Preprint

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Introduction: Predicting if a fetus with borderline left heart structures and coarctation of the aorta (CoA) will require single ventricle palliation (SVP) is challenging, partly due to the limitations of fetal echocardiography in defining valvar abnormalities. Fetal echocardiographic findings predictive of SVP, particularly in relation to the mitral valve (MV), are not well defined. Methods: We performed a retrospective review of fetuses with postnatally confirmed CoA from 2010 to 2020. Fetuses with complex congenital heart disease or unequivocal hypoplastic left heart syndrome were excluded. Data were compared between those who underwent biventricular repair (BVR) vs. SVP, cardiac death or orthotopic heart transplant (OHT) to determine differences in fetal echocardiograms. Results: Of 67 fetuses with 131 total echocardiograms, 62 (93%) underwent BVR and 5 (7%) experienced SVP, cardiac death or OHT. Fetuses with confirmed CoA who experienced SVP, cardiac death, or OHT, had fetal MV z-scores that were 2.06 lower, on average, than those who underwent BVR (z-score = -3.98 vs. -1.92, 95% CI: -2.96, -1.16). The incidences of MV anomalies and left to right flow across the foramen ovale were higher in the SVP, cardiac death and OHT group. Conclusion: SVP, cardiac death or OHT in fetuses with confirmed CoA were associated with fetal MV hypoplasia, MV anomalies and left to right flow across the foramen ovale. These findings may help guide prenatal counseling about the likelihood of SVP, cardiac death or OHT in fetuses with CoA and borderline left heart structures.

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Section: Discussionmentioning

confidence: 99%