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Васильев, А. Э.; Краснюк, Иван Иванович; Ravikumar, S.; Maksimenko, Olga

doi:10.1023/a:1014722705266

Cited by 1 publication

(2 citation statements)

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“…From the release study, we concluded that PU films prepared with castor oil and EG could be used for the CR of IDM. On the basis of the release patterns given in the literature2, 36, 37 for the therapeutic TDD of IDM, we concluded that a lesser IDM dose regimen is required for TDD.…”

Section: Resultsmentioning

confidence: 76%

“…In contrast to widely accepted ointment medicinal forms, TDD allows drugs to be administered in an individual‐dose regimen and provides prolonged treatment. Being able to release the drug in a timely manner, TDD is useful for controlled release (CR) action over an extended period of time 2. Polymeric membranes prepared from natural and synthetic origins are usually used for TDD, of which some are commercially exploited 3.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of transdermal drug‐delivery films with castor‐oil‐based polyurethanes

Shelke

Sairam

Halligudi

et al. 2006

J of Applied Polymer Sci

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Two different types of polyurethanes (PUs) were prepared with castor oil, ethylene glycol, isophorene diisocyanate and castor oil, and isophoren diisocyanate and poly-(ethylene glycol) (400 or 600). PU films were prepared and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and gel permeation chromatography. We prepared transdermal patches by loading different amounts of drug, plasticizer, and penetration enhancer. In vitro drug permeability through the castor-oil-based aliphatic PU patches was examined with a Keshary-Chien diffusion cell. The effect of castor oil on the film-forming properties and the effect of penetration enhancers on diffusion characteristics of indomethacin (IDM) drug through the castor-oil-based PU were investigated. Prolonged release of IDM was observed from the prepared PU patches. In vitro drug diffusion revealed that slow and prolonged release of IDM was achieved in the absence of penetration enhancers. The use of penetration enhancers showed a significant effect on drug diffusion.

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Section: Resultsmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%