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Abstract

In intact August rats, the cardiac contractile function at rest was by 76% higher than in Wistar rats, while their hearts, both intact and after acute myocardial infarction, were more resistant to isometric load than the hearts of Wistar rats. Postinfarction mortality in August rats was 18% vs. 70% in Wistar rats. Adrenoreactivity of the myocardium in August rats was decreased compared to that in Wistar rats. These peculiarities can determine high resistance of August rats to myocardial infarction.

Adaptation of the cardiovascular system to postinfarction cardiosclerosis in rats with congenital adrenoreactivity of the myocardium

“…Over the 1st month of the study, the mortality rate in August rats was much lower than in Wistar rats (11 and 26%, respectively). It should be emphasized that August rats differed from Wistar rats by increased SFR (Table 1), which is consistent with published data [3]. This parameter in sham-operated August and Wistar rats differed by 35% (p<0.001).…”

“…Published data show that the mortality rate and incidence of arrhythmias and contractile dysfunction caused by acute myocardial infarction in August rats are much lower than in Wistar rats [1,3,9]. Stress-induced activation of the sympathoadrenal system (SAS) plays an important role in the pathogenesis of ischemic damage to the myocardium.…”

“…Activity of the parasympathetic nervous system and baroreflex sensitivity are reduced in August rats [4], which serves as a risk factor during myocardial infarction and heart failure [11]. It was demonstrated that high resistance of August rats to acute ischemia is determined by reduced adrenoreactivity of the myocardium (compared to Wistar rats) [3]. This phenomenon in August rats can be also associated with less significant activation of SAS under stress conditions [2].…”

Resistance to Neurodegenerative Brain Damage in August and Wistar Rats

“…Since emotional stress plays an important role in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) [12,13,14], we hypothesized that genetically determined increase in organism's resistance to stress can counteract the development of this disorder. Published data show that the incidence of acute myocardial infarction in August rats is lower than in Wistar rats [2]. It should be emphasized that the development of this disease is closely related to emotional stress.…”

Ca2+ Transport into Sarcoplasmic Reticulum and Immediate-Early Response Proteins in the Myocardium of Rats Resuscitated after Systemic Circulatory Arrest

“…Differences were revealed in the resistance to acute myocardial infarction in August and Wistar rats differing by parameters of stress reactivity [3]. Stability of myocardial antioxidant defense system during ischemic and reperfusion injury also differs in these animals [9], which correlated with the resistance of contractile function to these conditions.…”