In the last years Science and Technology Parks (STPs) have been considered facilitators of interorganizational relationships, as well as instruments of public policy, by creating networks and allowing access for the learning of local innovation. In this study, we propose a quantitative tool as support for measuring the efficiency of STPs through the analysis of the complex networks they form. We present a generic framework called the InterRelationship Science-Park Analysis (ISA) framework to study STPs at three different levels of management: i) individual entities (research centres, universities, innovation companies, etc.); ii) STP global management; and iii) productive sector development. Moreover, we have applied the ISA framework to a real world case study: the Walqa Science and Technology Park. Through it we have been able to know what relationships are established within this Science and Technology Park and which are the most important nodes in this network of interactions.