Untitled

2009

Materials

Organotin polyethers are easily synthesized employing interfacial polymerization systems involving the reaction of hydroxyl-containing Lewis bases and organotin halides. A wide variety of organotin-containing polymeric products have been synthesized including those derived from natural and synthetic polymers such as lignin, xylan, cellulose, dextran, and poly(vinyl alcohol). Others have been synthesized employing known drug diols such as dicumarol, DES, and dienestrol and a wide variety of synthetic diols. Included in these materials are the first water soluble organotin polymers. The organotin polyethers exhibit a wide range of biological activities. Some selectively inhibit a number of unwanted bacteria, including Staph. MRSA, and unwanted yeasts such as Candida albicans. Some also inhibit a variety of viruses including those responsible for herpes infections and smallpox. Others show good inhibition of a wide variety of cancer cell lines including cell lines associated with ovarian, colon, lung, prostrate, pancreatic and breast cancer. The synthesis, structural characterization, and biological characterization of these materials is described in this review.

Section: Resultsmentioning

confidence: 99%

Organotin Polyethers as Biomaterials

2009

Materials

“…The advantages of polymeric drugs have been recently reviewed emphasizing their use in combating cancer [8][9][10][13][14][15][16][17][18]. Following briefly describes some of these advantages in comparison to small, monomeric drugs.…”

Section: Advantages Of Polymer Drugsmentioning

confidence: 99%

Control of Prostate Cancer Using Organotin Polymers

J Inorg Organomet Polym

Shahi

et al. 2014

The current efforts described in this paper are aimed at developing compounds that inhibit the growth of prostate cancer and to identify structure/property relationships that will further assist us towards this goal. The growth of prostate cancer is affected employing a wide range of organotin condensation polymers. The EC 50 values are primarily dependant on the nature of the Lewis base but the CI 50 is dependent on both the nature of the Lewis base and Lewis acid. EC 50 values down to the picogram/ mL range are found. A number of products exhibit CI 50 values greater than two. For polymers derived from hydroquinone and hydroquinone derivatives ability to inhibit cancer cell growth decreases as the bulk of substituents increases.

“…The advantages of polymeric drugs have been recently reviewed emphasizing their use in combating cancer [9][10][11][14][15][16][17][18][19]. Some advantages in comparison to small, monomeric drugs are briefly described subsequently.…”

Section: Advantages Of Polymer Drugsmentioning

confidence: 99%

Control of Breast Cancer Using Organotin Polymers

International Journal of Polymeric Materials and Polymeric Biom

Shahi

et al. 2015

The efforts described in this article are aimed at designing organotin polymers that control the growth of breast cancer and to identify structure=property relationships that assist in this goal. The growth of MCF-7 and MDA-MB-231 breast cancer cell lines is inhibited employing a wide range of organotin condensation polymers. The EC 50 values are primarily dependent on the nature of the Lewis base but the CI 50 is dependent on both the nature of the Lewis base and Lewis acid. A number of products exhibit CI 50 values greater than two including a number of organotin polyethers such as those derived from diethylstilbestrol, dienestrol, short-chained dibutyltin polyethers, and hydroquinone derivatives. In most of these cases the MDA-MB-231 cells exhibit greater inhibition compared to the estrogen receptor (ER) MCF-7 cells. The organotin polymers generally exhibit a superior ability to inhibit MCF-7 and MDA-MB-231 breast cell growth compared to the standard cisplatin.