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Abstract

Here, recent literature on the use of omalizumab in sino-nasal allergic diseases is reviewed. Omalizumab is an anti-human IgE humanized monoclonal antibody produced against CƐ3 domain of the Fc fragment of IgE molecule. Omalizumab suppresses the effector functions of IgE by preventing binding to high-affinity receptors (FcεR1) on allergy related immune effector cells, blocking mast cell or basophil mediator release. Omalizumab is helpful mainly in ragweed/birch pollen-induced seasonal and perennial allergic rhinitis rather than uncontrolled and concomitant allergic rhinitis and asthma/chronic rhino-sinusitis/nasal polyposis.