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Abstract

Background:The World Health Organization in 2002 defined probiotics as living organisms, in which foods and dietary supplements can be found that, when ingested, can improve the health of the host. Disturbances of intestinal biology contribute to the pathogenesis of DM. Studies have shown that the gut microbiome plays a role in the development and progression of type 1 and type 2 diabetes and its complications. This study was designed to evaluate the effects of multi-species of probiotic supplementation on fasting blood glucose, lipid profile, inflammatory biomarkers, and body weight changes in type 2 diabetic patients.Participants and methods: 65 type 2 diabetics were divided into 2 groups T (trial) and C (control) or placebo. The T group received daily one capsule of 1 species of probiotic and C group received capsules filled with roasted ground chickpea. Fasting blood glucose, Serum Tumor Necrosis Factor alpha (TNFα) and C Reactive Protein (CRP), HDLC, LDLC, TG, TC levels and BMI were measured at beginning and the end of the study which lasted for 10 weeks.Results and discussion: Fasting plasma glucose significantly reduced in the probiotic group compared to the control group respectively, 131.