Untitled

Abstract

Peptides are recognized for being highly selective efficacious and at the same time, relatively safe and well tolerated. Consequently, there is an increased interest in peptides, in pharmaceutical research and development (R&D) and approximately 140 peptide therapeutics are currently being evaluated in clinical trials. Ultrasonic is an area of intense scientific and technological research, science and technology of ultrasonics are widely used in the recent years for industrial and medical applications. Ultrasonic investigation in non-aqueous solutions of electrolytes and non-electrolytes with amino acids provide useful information in understanding the behaviour of liquid/solution system. In the present work, the ultrasonic velocity of a peptide with drug in formamide have been measured at various concentrations and at different temperatures. Using the measured value the thermodynamic parameters and acoustical parameters are calculated. These parameters have been utilized to study the interionic and intermolecular interactions existing in the system. The results arrived from ultrasonic methods have been corroborated with antimicrobial study. During the past decade, peptides have gained a wide range of applications in medicine, biotechnology and therapeutic peptide research is also currently experiencing a renaissance for commercial reasons 6 . One of these systems is peptide-mediated drug delivery which has been extensively applied to a wide range of cargo molecules 7 .Cell penetrating peptides (CPPs) provides a promising solution to the problems commonly related to the drug delivery of conventional cancer chemotherapeutics as well as oligonucleotide based treatments. Many sulpha drugs like sulphadiazine, sulphamethoxazole, sulphamerazine possess SO 2 NH moiety as an important toxophoric function 8 . Sulfadiazine is a useful antibacterial drug with a typical sulphonamide structure.