BACKGROUND: ICT based mobile working gives organizational flexibility, productivity and performance but at the same time it can lead to techno-stress and technostrain perceptions. A high level of technostrain amongst ICT-based mobile workers would impact their well-being, leading to lesser than expected gains from such organizational ICT investments. Given this paradox, we examine the actual transactional and relational stressor-strain coping response processes in this novel context. OBJECTIVE: The broad research aim of this paper is to explain the relative importance of the cognitive and affective processes used amongst ICT-based mobile workers when coping with technostressors. METHODS: Specifically, based on technology frames literature, we develop dual-path serial mediation models, showing the relationships between technostress-technostrain via two processes: (a) the primary cognitive appraisal process mobilization (threat/opportunity technology frame) and (b) the secondary affective resource process mobilization (affect towards ICT use) to account for technostrain perceptions. We use survey data from 165 ICT-based mobile managers from diverse work settings to empirically confirm the theorized models. RESULTS/CONCLUSIONS: A predominant cognitive ‘threat frames’ leads to increase in technostrain, which decreases if ‘affective resource’ is available for coping. This relationship is inverse in the case of ‘opportunity frames’ path, as technostrain perceptions decreases with and without affective resource mobilization. Implications to theory, practice and methods are also discussed.