Zanthoxylum alatum attenuates lipopolysaccharide-induced depressive-like behavior in mice hippocampus

Barua, Chandana Choudhury; Saikia, Bhaskar; Ren, Xinguo; Elancheran, R.; Pathak, Devendra; Tamuli, Shantanu; Barua, Acheenta Gohain

doi:10.4103/pm.pm_606_17

Cited by 7 publications

(6 citation statements)

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“…Although the findings of several studies have indicated the preventive effects of antidepressants or natural products on LPS-induced behavioral changes, similar therapeutic effects could not be demonstrated [74,75]. In contrast, other authors have demonstrated that posttreatment administration of synthetic or natural compounds can mitigate LPSinduced depressive behavior in mice [18,76,77]. ese seemingly contradictory observations serve to highlight the differences in the pharmacological effects between compounds as well as biological outcomes when using distinct experimental protocols [42].…”

Section: Discussionmentioning

confidence: 97%

Involvement of Anti-Inflammatory and Stress Oxidative Markers in the Antidepressant-like Activity of Aloysia citriodora and Verbascoside on Mice with Bacterial Lipopolysaccharide- (LPS-) Induced Depression

Gomes

Serpa

Miorando

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Aloysia citriodora Palau is popularly used to treat nervous disorders. Experimental evidence has indicated that verbascoside (VBS) isolated from A. citriodora has pharmacological potential. In this study, we evaluated the antidepressant-like effects of a hydroalcoholic extract of A. citriodora (HEAc) and VBS against lipopolysaccharide- (LPS-) induced depressive-like behavior in mice. In the pretreatment protocol (performed to evaluate the preventive potential), mice were pretreated with HEAc (3, 30, or 300 mg/kg) or VBS (30 mg/kg) before the administration of LPS. In the posttreatment protocol (performed to evaluate the therapeutic potential), mice were initially administered LPS and were subsequently given HEAc (3, 30, or 300 mg/kg) or VBS (30 mg/kg). In both treatments, the mice were submitted to an open-field test and tail suspension test (TST) at 6 and 24 h after LPS administration. The posttreatment evaluation revealed that HEAc (30 or 300 mg/kg) and VBS produced an antidepressant-like effect, as indicated by a reduction in the time spent with no movement in the TST. Moreover, HEAc (30 or 300 mg/kg) was found to reduce interleukin-6 (IL-6) levels and N-acetyl-glycosaminidase activity in the hippocampus, increase glutathione (GSH) levels in the hippocampus and cortex, and enhance IL-10 in the cortex and, at a dose of 300 mg/kg, reduced myeloperoxidase activity in the cortex. Contrastingly, no comparable effects were detected in mice subjected to the pretreatment protocol. Administration of VBS similarly reduced the levels of IL-6 in the hippocampus and increased GSH levels in the cortex. Our observations indicate that both HEAc and VBS show promising antidepressant-like potential, which could be attributed to their beneficial effects in reducing neuroinflammatory processes and antioxidant effects in the central nervous system.

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Section: Discussionmentioning

confidence: 97%

Involvement of Anti-Inflammatory and Stress Oxidative Markers in the Antidepressant-like Activity of Aloysia citriodora and Verbascoside on Mice with Bacterial Lipopolysaccharide- (LPS-) Induced Depression

Gomes

Serpa

Miorando

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…Group III (Donepezil): OVX/D-Gal-subjected rats received donepezil (5 mg/kg/day) (Ademosun et al 2022 ) orally for 42 days, given 1 h prior to D-Gal administration. Group IV, V, and VI ( E. bonariensis 50, 100, and 200 mg/kg/day): OVX/D-Gal-subjected rats received the alcoholic extract of E. bonariensis at three different doses (50, 100, and 200 mg/kg/day) (Barua et al 2019 ; El-Akhal et al 2021 ) orally for 42 days, given 1 h prior to D-Gal administration. Before the end of the experiment by 4 days, all animals were subjected to the Morris water maze (MWM) test for memory performance evaluation.…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS

Ibrahim,

Sayed,

Abdelhameed

et al. 2024

Inflammopharmacol

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Erigeron bonariensis is widely distributed throughout the world's tropics and subtropics. In folk medicine, E. bonariensis has historically been used to treat head and brain diseases. Alzheimer’s disease (AD) is the most widespread form of dementia initiated via disturbances in brain function. Herein, the neuroprotective effect of the chemically characterized E. bonariensis ethanolic extract is reported for the first time in an AD animal model. Chemical profiling was conducted using UPLC–ESI-MS analysis. Female rats underwent ovariectomy (OVX) followed by 42 days of D-galactose (D-Gal) administration (150 mg/kg/day, i.p) to induce AD. The OVX/D-Gal-subjected rats received either donepezil (5 mg/kg/day) or E. bonariensis at 50, 100, and 200 mg/kg/day, given 1 h prior to D-Gal. UPLC–ESI-MS analysis identified 42 chemicals, including flavonoids, phenolic acids, terpenes, and nitrogenous constituents. Several metabolites, such as isoschaftoside, casticin, velutin, pantothenic acid, xanthurenic acid, C18-sphingosine, linoleamide, and erucamide, were reported herein for the first time in Erigeron genus. Treatment with E. bonariensis extract mitigated the cognitive decline in the Morris Water Maze test and the histopathological alterations in cortical and hippocampal tissues of OVX/D-Gal-subjected rats. Moreover, E. bonariensis extract mitigated OVX/D-Gal-induced Aβ aggregation, Tau hyperphosphorylation, AChE activity, neuroinflammation (NF-κBp65, TNF-α, IL-1β), and apoptosis (Cytc, BAX). Additionally, E. bonariensis extract ameliorated AD by increasing α7-nAChRs expression, down-regulating GSK-3β and FOXO3a expression, and modulating Jak2/STAT3/NF-ĸB p65 and PI3K/AKT signaling cascades. These findings demonstrate the neuroprotective and memory-enhancing effects of E. bonariensis extract in the OVX/D-Gal rat model, highlighting its potential as a promising candidate for AD management. Graphical Abstract

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“…The samples were dissolved with methanol and followed the previous method with a slight modification. 30, 31 The extracts were passed through a Hypersil Gold C 18 column (1.9) with a gradient mobile phase of solvent A: water and solvent B: acetonitrile at a constant flow rate of 0.2 mL/min. Using an electrospray ionisation (ESI) source, all MS/MS studies were carried out in both positive and negative modes.…”

Section: Methodsmentioning

confidence: 99%

“…The mass-to-charge ratio was compared to the literature and mass databases to characterize the extract contents. 31, 32…”

Section: Methodsmentioning

confidence: 99%

Influence of Drying Condition on Nutritional and Chemical Profile of Garcinia pedunculata Roxb. Fruit

Bhattacharjee

Elancheran

Deb

et al. 2023

Pharmacognosy Magazine

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Background Garcinia pedunculata (GP) Roxb. is a traditional medicinal plant used for treating gastrointestinal disorders. The fruit is always consumed in dried form in cuisines and as medicine. Objectives To study the effect of drying conditions (shade, oven, and traditional sun drying) on the nutritional profile of GP while assessing the choice of solvent extraction for the maximum phytocompounds extraction; their in vitro biological activities and chemical profiling. Materials and Methods The fruits were cut into thin 0.9 ± 0.3 cm slices and dried in the shade (25–30°C), sun (34–40°C), and oven (70–80°C). The extraction was done using methanol, hydromethanol, ethanol, hydroethanol, and water. HPLC and LC-ESI-MS/MS were used to identify the bioactive compounds. Results In this study, the impact of three drying conditions has been investigated and established that shade-dried (ShD) has a better-preserved nutritional profile. In terms of phytochemical extraction, comparatively higher amounts of phenols (394.00 ± 12.28 mg Gallic acid equivalent (GAE)/g of dried sample) and flavonoids (72.62 ± 2.06 mg Quercetin/g of dried sample) were recorded in the shade-dried hydromethanolic extract (ShDMH), which was directly in line with the better antioxidant activity (IC50 for 1,1-diphenyl-2-picrylhydrazyl (DPPH), 647.99 ± 7.66 µg/mL, 2,2’-azino-bis(3-ethylbenzothiazoline)6-sulfonic acid (ABTS), 762.02 ± 18.74 µg/mL) and enzyme-inhibitory potential (IC50 for α- glucosidase 1908.06 ± 13.26 µg/mL and for lipase 613.59 ± 7.57 µg/mL) of this extract. Conclusion The conclusive evidence from this study indicates that shade drying and extraction with hydromethanolic solvent preserves most of the nutritional components and has a higher extraction yield with well-conserved phytochemical composition. Also, these bioactive compounds such as hydroxycitric acid, GB-1a, garcinone A, 9-hydroxycalabaxanthone, chlorogenic acid, and garcinol are present in these extracts. This fruit, although beneficial is still underutilized, and this outcome is believed to be significantly valuable for the further aspects of GP fruit-based nutraceutical or phytopharmaceutical development.

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Zanthoxylum alatum attenuates lipopolysaccharide-induced depressive-like behavior in mice hippocampus

Cited by 7 publications

References 0 publications

Involvement of Anti-Inflammatory and Stress Oxidative Markers in the Antidepressant-like Activity of Aloysia citriodora and Verbascoside on Mice with Bacterial Lipopolysaccharide- (LPS-) Induced Depression

Involvement of Anti-Inflammatory and Stress Oxidative Markers in the Antidepressant-like Activity of Aloysia citriodora and Verbascoside on Mice with Bacterial Lipopolysaccharide- (LPS-) Induced Depression

Neuroprotective potential of Erigeron bonariensis ethanolic extract against ovariectomized/D-galactose-induced memory impairments in female rats in relation to its metabolite fingerprint as revealed using UPLC/MS

Influence of Drying Condition on Nutritional and Chemical Profile of Garcinia pedunculata Roxb. Fruit

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