ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

Chan, Andrew C.; Iwashima, Makio; Turck, Christoph W.; Weiss, Arthur

doi:10.1016/0092-8674(92)90598-7

Cited by 993 publications

(769 citation statements)

References 64 publications

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“…Although it was shown that ZAP-70 is the key molecule for TCR signaling, 46 Syk also associates with TCR subunits and undergoes tyrosine phosphorylation after TCR stimulation, 47 which suggests its role during Tc activation. Furthermore, not only activation and expansion but also migration of Tc is a major requirement for GvHD.…”

Section: Discussionmentioning

confidence: 99%

Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels

Leonhardt

Zirlik²,

Buchner

et al. 2012

Leukemia

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Section: Discussionmentioning

confidence: 99%

Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels

Leonhardt

Zirlik²,

Buchner

et al. 2012

Leukemia

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“…GIP-15 is Hepatocyte Growth Factor Like/Macrophage Stimulating Factor (HGFL/MSP) (Han and Degen, 1993). GIP-16 is Zap-70 (Chan et al, 1992). GIP-17 is homologous to IgH G3.…”

Section: Gip-6mentioning

confidence: 99%

Isolation and characterization of sixteen novel p53 response genes

Kostic

Shaw

2000

Oncogene

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“…In contrast to Syk, the expression of Zap70 appears to be more restricted, with the highest levels of Zap70 in the T and NK cell lineages [15]. Genetic ablation of Zap70 causes a block in T cell development, with no cells progressing beyond the CD4 + CD8 + double-positive (DP) thymocyte stage [16,17].…”

Section: Introductionmentioning

confidence: 99%

Redundant role for Zap70 in B cell development and activation

Fallah-Arani

Schweighoffer²,

Vanes³

et al. 2008

Eur J Immunol

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Expression of the Syk family tyrosine kinase Zap70 is strongly correlated with poor clinical outcome in chronic lymphocytic leukemia, the most common human leukemia characterized by B cell accumulation. The expression of Zap70 may reflect the specific cell of origin of the tumor or may contribute to pathology. Thus, the normal role of Zap70 in B cell physiology is of great interest. While initial studies reported that Zap70 expression in the mouse was limited to T and NK cells, more recent work has shown expression in early B cell progenitors and in splenic B cells, suggesting that the kinase may play a role in the development or activation of B cells. In this study, we show that Zap70 is expressed in all developing subsets of B cells as well as in recirculating B cells, marginal zone B cells and peritoneal B1 cells. Analysis of Zap70-deficient mice shows no unique role for Zap70 in either the development of B cells or in their in vitro and in vivo activation. However, we show that Zap70 can rescue the defective positive selection of immature B cells into the recirculating pool in Syk-deficient mice, demonstrating functional redundancy between these two kinases.

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ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

Cited by 993 publications

References 64 publications

Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels

Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels

Isolation and characterization of sixteen novel p53 response genes

Redundant role for Zap70 in B cell development and activation

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