The construction of reservoirs has a major impact on the floodplain landscape, and their existence also affects land use in the hinterland. The aim of this article is to evaluate the influence of artificial lakes on changes in landscape use and transport networks; in this context, an assessment is provided of the significance of this anthropogenic activity as one of the drivers of landscape change. Old topographic maps and archival aerial photographs are used to analyze changes in the use of landscape and road networks, and these materials are complemented with the latest geographic data in digital form. Utilizing geographic information systems, we assessed the landscape changes and processes in the hinterland of those Czech Republic reservoirs that have an area of 100 ha or more. The results of the research show that landscape change processes are more intensive in the hinterland of the lakes than in the surrounding landscape. The predominant utility function of a reservoir emerged as a key factor in landscape use changes and ongoing processes. A different landscape use scenario can be observed in drinking water reservoirs, especially regarding the leisure and irrigation functions that dominate elsewhere. After the completion of reservoirs, the road and railway networks had an impact on, above all, the connection of the nearest villages in the hinterland of the lakes. The information that we found can be employed in projecting future changes in land use and road networks at newly planned dams.