Zearalenone affects reproductive functions of male offspring via transgenerational cytotoxicity on spermatogonia in mouse

Zhou, Yewen; Zhang, Di; Sun, Dehao; Cui, Sheng

doi:10.1016/j.cbpc.2020.108766

Cited by 12 publications

(3 citation statements)

References 61 publications

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“…Mycotoxin contamination in food and feed cause acute and chronic mycotoxicosis, including teratogenic, carcinogenic, oestrogenic, neurotoxic, and immunosuppressive effects. Mycotoxins also serve as a crucial factor governing the safety for human consumption as they pose a serious threat to microbiological food safety and human health [3][4][5]. The incident of mycotoxin contamination may occur at any stages of culturing, harvesting and storage [6].…”

Section: Introductionmentioning

confidence: 99%

Occurrence, Impact on Agriculture, Human Health, and Management Strategies of Zearalenone in Food and Feed: A Review

Mahato

Devi

Pandhi

et al. 2021

Toxins

104

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Mycotoxins represent an assorted range of secondary fungal metabolites that extensively occur in numerous food and feed ingredients at any stage during pre- and post-harvest conditions. Zearalenone (ZEN), a mycotoxin categorized as a xenoestrogen poses structural similarity with natural estrogens that enables its binding to the estrogen receptors leading to hormonal misbalance and numerous reproductive diseases. ZEN is mainly found in crops belonging to temperate regions, primarily in maize and other cereal crops that form an important part of various food and feed. Because of the significant adverse effects of ZEN on both human and animal, there is an alarming need for effective detection, mitigation, and management strategies to assure food and feed safety and security. The present review tends to provide an updated overview of the different sources, occurrence and biosynthetic mechanisms of ZEN in various food and feed. It also provides insight to its harmful effects on human health and agriculture along with its effective detection, management, and control strategies.

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Section: Introductionmentioning

confidence: 99%

Occurrence, Impact on Agriculture, Human Health, and Management Strategies of Zearalenone in Food and Feed: A Review

Mahato

Devi

Pandhi

et al. 2021

Toxins

104

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“…Other studies confirmed that ZEN also has toxic effects on the offspring of exposed animals. Exposure to ZEN reduced the number of piglets born alive and the litter birth weights of pregnant sows, and it was also reported to affect the reproductive functions of male offspring of pregnant mice via transgenerational cytotoxicity on spermatogonia [9,10]. In addition, ZENs are also hepatotoxic [11,12], genotoxic [13,14], and immunotoxic [15,16].…”

Section: Introductionmentioning

confidence: 99%

Determination of Zearalenone and Its Derivatives in Feed by Gas Chromatography–Mass Spectrometry with Immunoaffinity Column Cleanup and Isotope Dilution

Luo

Liu

Guo

et al. 2022

Toxins

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In this study, a gas chromatography–mass spectrometry (GC-MS) method was established for the determination of zearalenone and its five derivatives in feed, including zearalanone, α-zearalanol, β-zearalanol, α-zearalenol, and β-zearalenol. An effective immunoaffinity column was prepared for sample purification, which was followed by the silane derivatization of the eluate after an immunoaffinity chromatography analysis for target compounds by GC-MS. Matrix effects were corrected by an isotope internal standard of zearalenone in this method. The six analytes had a good linear relationship in the range of 2–500 ng/mL, and the correlation coefficients were all greater than 0.99. The limits of detection (LODs) and limits of quantification (LOQs) were less than 1.5 μg/kg and 5.0 μg/kg, respectively. The average spike recoveries for the six feed matrices ranged from 89.6% to 112.3% with relative standard deviations (RSDs) less than 12.6%. Twenty actual feed samples were analyzed using the established method, and at least one target was detected. The established GC-MS method was proven to be reliable and suitable for the determination of zearalenone and its derivatives in feed.

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“…Animais expostos à toxicidade reprodutiva causada pela ZEN manifestam infertilidade, aumento no tamanho dos ovários e útero, diminuição na contagem de células espermáticas, redução nos níveis de hormônios reprodutivos e queda nas taxas de prenhez (Alshannaq & Yu, 2017;L. Li et al, 2021;Zhou et al, 2020).…”

Section: Zearalenonaunclassified

Avaliação da eficácia de diferentes adsorventes para redução de efeitos tóxicos combinados de micotoxinas na alimentação de vacas em lactação

Fonsêca

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Avaliação da eficácia de diferentes adsorventes para redução de efeitos tóxicos combinados de micotoxinas na alimentação de vacas em lactação / Luzianna Macedo Fonseca. --versão revisada de acordo com a Resolução CoPGr 6018 de 2011 --Piracicaba, 2024. 90 p. Dissertação (Mestrado) --USP / Escola Superior de Agricultura "Luiz de Queiroz".1. Multi-micotoxinas 2. Aditivos antimicotoxinas 3. Redução de micotoxinas 4. Vacas leiteiras 5. Adsorventes I. Título AGRADECIMENTOSPrimeiramente, agradeço a Deus, por Sua constante orientação e força que me permitiram superar desafios e me tornar uma pessoa melhor, valorizando ainda mais a vida. Agradeço por me ajudar a crescer diariamente.A mim por nunca desistir, por enfrentar noites mal dormidas, medos e ansiedades. Esses desafios foram fundamentais na construção das pontes que me levaram ao orgulho de superá-los e alcançar com êxito meus objetivos.À minha avó, Maria Edite Venceslau Fonseca (in memoriam), agradeço por ter me apoiado incondicionalmente em momentos difíceis ao longo da minha jornada acadêmica e de vida. Ela esteve sempre ao meu lado.

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Zearalenone affects reproductive functions of male offspring via transgenerational cytotoxicity on spermatogonia in mouse

Cited by 12 publications

References 61 publications

Occurrence, Impact on Agriculture, Human Health, and Management Strategies of Zearalenone in Food and Feed: A Review

Occurrence, Impact on Agriculture, Human Health, and Management Strategies of Zearalenone in Food and Feed: A Review

Determination of Zearalenone and Its Derivatives in Feed by Gas Chromatography–Mass Spectrometry with Immunoaffinity Column Cleanup and Isotope Dilution

Avaliação da eficácia de diferentes adsorventes para redução de efeitos tóxicos combinados de micotoxinas na alimentação de vacas em lactação

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