Zearalenone induces the senescence of cardiovascular cells in vitro and in vivo

Wang, Kaihao; Zhou, Min; Du, Yipeng; Li, Peixin; Huang, Zheng

doi:10.1007/s11356-023-25869-x

Cited by 3 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reproductive toxicity, immunotoxicity [7], and liver and kidney toxicity [8] can occur when food contaminated with ZEN and its associated derivatives are ingested. ZEN has been reported to cause cardiovascular aging-related injuries [9]. According to data from the Food and Agriculture Organization and the World Health Organization, mycotoxin contamination rates are as high as 25% in food crops worldwide [10].…”

Section: Introductionmentioning

confidence: 99%

A Novel Bacillus Velezensis for Efficient Degradation of Zearalenone

Li,

Chen,

et al. 2024

Foods

View full text Add to dashboard Cite

Zearalenone (ZEN) is considered one of the most serious mycotoxins contaminating grains and their by-products, causing significant economic losses in the feed and food industries. Biodegradation pathways are currently considered the most efficient solution to remove ZEN contamination from foods. However, low degradation rates and vulnerability to environmental impacts limit the application of biodegradation pathways. Therefore, the main research objective of this article was to screen strains that can efficiently degrade ZEN and survive under harsh conditions. This study successfully isolated a new strain L9 which can efficiently degrade ZEN from 108 food ingredients. The results of sequence alignment showed that L9 is Bacillus velezensis. Meanwhile, we found that the L9 degradation rate reached 91.14% at 24 h and confirmed that the primary degradation mechanism of this strain is biodegradation. The strain exhibits resistance to high temperature, acid, and 0.3% bile salts. The results of whole-genome sequencing analysis showed that, it is possible that the strain encodes the key enzyme, such as chitinase, carboxylesterases, and lactone hydrolase, that work together to degrade ZEN. In addition, 227 unique genes in this strain are primarily involved in its replication, recombination, repair, and protective mechanisms. In summary, we successfully excavated a ZEN-degrading, genetically distinct strain of Bacillus velezensis that provides a solid foundation for the detoxification of feed and food contamination in the natural environment.

show abstract

Section: Introductionmentioning

confidence: 99%

A Novel Bacillus Velezensis for Efficient Degradation of Zearalenone

Li,

Chen,

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

Revealing High-Efficiency Natural Mycotoxin Antidotes in Zebrafish Model Screening Against Zearalenone-Induced Toxicity

Zhang,

Jiang,

et al. 2024

Engineering

View full text Add to dashboard Cite

Reversing Zearalenone Toxicity: The Role of Hydroxytyrosol in Zebrafish

Zhang,

Zhou,

Jiang

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Zearalenone (ZEA) is a widely distributed mycotoxin that presents a substantial worldwide health risk to animals. Several natural compounds have shown promise in mitigating the detrimental impacts of ZEA. This study examined the detoxification potential of previously identified compounds by utilizing zebrafish embryos as a model organism. Hydroxytyrosol stands out among these natural compounds. Our findings indicate that hydroxytyrosol effectively mitigated mortality, hatching delay, and phenotypic abnormalities induced by ZEA in the assessed embryos. Furthermore, hydroxytyrosol restored the frequency and intensity of tail coiling (TC) while decreasing the expression of heat shock proteins (HSPs) in the zebrafish embryos. Extended incubation with hydroxytyrosol demonstrated protective effects on zebrafish growth and morphology, muscle birefringence, and touch-evoked escape behavior. Subsequent investigations indicated that hydroxytyrosol reversed the expression of proapoptotic targets (e.g., bax and caspase8) and cell cycle regulators (e.g., p21, gadd45a, and rbl2), thereby mitigating apoptosis and G2 cell cycle arrest induced by ZEA in zebrafish embryos. Additionally, hydroxytyrosol decreased staining for senescence associated-βgalactosidase (SA-β-Gal). Notably, p53/FoxO pathway plays an important role in detoxification mechanisms. Overall, these novel findings highlight the potential of hydroxytyrosol to reverse ZEA-induced toxicity in multiple aspects. The mitigating effect of hydroxytyrosol on ZEA toxicity may have been underestimated.

show abstract

Zearalenone induces the senescence of cardiovascular cells in vitro and in vivo

Cited by 3 publications

References 29 publications

A Novel Bacillus Velezensis for Efficient Degradation of Zearalenone

A Novel Bacillus Velezensis for Efficient Degradation of Zearalenone

Revealing High-Efficiency Natural Mycotoxin Antidotes in Zebrafish Model Screening Against Zearalenone-Induced Toxicity

Reversing Zearalenone Toxicity: The Role of Hydroxytyrosol in Zebrafish

Contact Info

Product

Resources

About