Zearalenone promotes porcine ESCs apoptosis by enhancing Drp1-mediated mitochondrial fragmentation and activating the JNK pathway

Hai, Sirao; Zhao, Jie; Chen, Chuangjiang; Wang, Chenlong; Ma, Li; Rahman, Sajid Ur; Zhao, Chang; Feng, Shibin; Wu, Jinjie; Wang, Xichun

doi:10.1016/j.fct.2023.114110

Food and Chemical Toxicology

2023

DOI: 10.1016/j.fct.2023.114110

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Zearalenone promotes porcine ESCs apoptosis by enhancing Drp1-mediated mitochondrial fragmentation and activating the JNK pathway

Sirao Hai,

Jie Zhao,

Chuangjiang Chen

et al.

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2024

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Cited by 2 publications

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Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway

Wang,

Yang

et al. 2024

J. Agric. Food Chem.

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Zearalenone (ZEA) induces oxidative damage in porcine endometrial stromal cells (ESCs), which is a critical factor affecting the growth and reproduction of female pigs. We hypothesize that rutin, a flavonoid antioxidant, can alleviate ZEA-induced cellular damage through the p53 signaling pathway. In this experiment, porcine ESCs were used as a research model. After transfection with siRNA to silence the p53 gene, rutin and ZEA were added to the cocultured porcine ESCs. Rutin notably reduced the ZEA-induced apoptosis rate, ROS, MDA, and 4-HNE levels via the p53 pathway; lowered the expression of LC3, Beclin-1, p62, Bax, and CHOP; and significantly improved cell viability, GSH-Px, T-SOD enzyme activity, and Bcl-2 expression. It also inhibited both apoptosis and autophagy. These findings suggested a novel antioxidant mechanism by which rutin mitigated the toxic effects of ZEA, highlighting the role of the p53 gene knockdown in this process.

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Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway

Wang,

Yang

et al. 2024

J. Agric. Food Chem.

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Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2

Chen,

Wang,

Jiang

et al. 2024

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Zearalenone (ZEA) is a mycotoxin commonly found in moldy cereals and has a range of toxic effects that have seriously affected animal husbandry. Rutin, a natural flavonoid with antioxidant activities, has been studied for its potential involvement in mitigating ZEA-induced apoptosis in porcine endometrial stromal cells (ESCs) and its potential molecular mechanism, particularly concerning the expression of Nrf2. This study investigates the molecular pathways by which rutin alleviates ZEA-induced ESC apoptosis, focusing on the role of Nrf2. Experimental data reveal that ZEA suppresses Nrf2 nuclear translocation and reduces mitochondrial membrane potential (MMP), leading to oxidative stress, endoplasmic reticulum stress (ERS), and mitochondrial pathway-driven apoptosis. Notably, rutin mitigates ZEA-induced apoptosis through Nrf2 activation. These findings highlight Nrf2 as a critical factor in rutin’s protective effects against ZEA-induced apoptosis, offering valuable insights for the clinical prevention and treatment of ZEA toxicity.

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Zearalenone promotes porcine ESCs apoptosis by enhancing Drp1-mediated mitochondrial fragmentation and activating the JNK pathway

Cited by 2 publications

References 36 publications

Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway

Rutin Attenuates the Oxidative Damage Induced by Zearalenone in Piglet Endometrial Stromal Cells via the p53 Signaling Pathway

Rutin Alleviates Zearalenone-Induced Endoplasmic Reticulum Stress and Mitochondrial Pathway Apoptosis in Porcine Endometrial Stromal Cells by Promoting the Expression of Nrf2

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