Zeb2/Axin2-Enriched BMSC-Derived Exosomes Promote Post-Stroke Functional Recovery by Enhancing Neurogenesis and Neural Plasticity

Wei, Rui Hua; Zhang, Lin; Hu, Wei; Shang, Xinying; He, Yuyan; Zhang, Wei

doi:10.1007/s12031-021-01887-7

Cited by 29 publications

(13 citation statements)

References 51 publications

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“…Exosome proteins are implicated in antigen presentation, immune reaction, cell binding, and catalytic activity. In addition, proteins (such as brain-derived neurotrophic factor, Zeb2/Axin2) of exosomes participate in brain repair, involving neurogenesis, antiapoptotic processes, and synaptic transmission [ 40 , 41 ]. Of the exosome cargo, microRNAs appear to participate in multiple biological processes [ 42 ].…”

Section: Characteristics Of Exosomesmentioning

confidence: 99%

“…Exosomes originating from MSCs mediated miR-133b delivery to neurons and astrocytes, which led to the downregulation of CTGF and the secondary release of exosomes from astrocytes, subsequently contributing to neurite outgrowth [ 86 , 87 , 88 ]. Additionally, Ex-Zeb2/Axin2-enriched exosomes from BMMSCs decreased the expression of SOX10, endothelin-3/EDNRB, and Wnt/β-catenin in MCAO rats, finally improving neuroplasticity and functional recovery [ 41 ]. In summary, the utilization of exosomes with active components could be part of a scheme to enhance neurogenesis and activate neuroplasticity, improving neurological recovery after ischemic stroke.…”

Section: Potential Therapeutic Effects Of Exosomes In Ischemic Strokementioning

confidence: 99%

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Potential Role of Exosomes in Ischemic Stroke Treatment

Jiang

Chen

et al. 2022

Biomolecules

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Ischemic stroke is a life-threatening cerebral vascular disease and accounts for high disability and mortality worldwide. Currently, no efficient therapeutic strategies are available for promoting neurological recovery in clinical practice, except rehabilitation. The majority of neuroprotective drugs showed positive impact in pre-clinical studies but failed in clinical trials. Therefore, there is an urgent demand for new promising therapeutic approaches for ischemic stroke treatment. Emerging evidence suggests that exosomes mediate communication between cells in both physiological and pathological conditions. Exosomes have received extensive attention for therapy following a stroke, because of their unique characteristics, such as the ability to cross the blood brain–barrier, low immunogenicity, and low toxicity. An increasing number of studies have demonstrated positively neurorestorative effects of exosome-based therapy, which are largely mediated by the microRNA cargo. Herein, we review the current knowledge of exosomes, the relationships between exosomes and stroke, and the therapeutic effects of exosome-based treatments in neurovascular remodeling processes after stroke. Exosomes provide a viable and prospective treatment strategy for ischemic stroke patients.

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Section: Characteristics Of Exosomesmentioning

confidence: 99%

Section: Potential Therapeutic Effects Of Exosomes In Ischemic Strokementioning

confidence: 99%

Potential Role of Exosomes in Ischemic Stroke Treatment

Jiang

Chen

et al. 2022

Biomolecules

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“…Guo et al revealed A miR-206-3p expression in orofacial mesenchymal stem cell (OMSC)-derived exosomes targeting bone morphogenetic protein-3 (Bmp3) and nuclear factor of activated T-cells, the cytoplasmic one (NFATc1), that may regulate orofacial bone development and establish the balance between osteoblasts and osteoclasts that is essential for orofacial bone formation . In addition to application of natural BMSC exosomes, exosomes enriched with Zeb2/Axin2 proteins are also used to achieve improvement in poststroke neuroplasticity and functional recovery in rat models …”

Section: Neural Crest Stem Cells: Bone Marrowmentioning

confidence: 99%

Exosomes as Neurological Nanosized Machines

et al. 2022

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In the past few decades, nanomedicine research has advanced dramatically. In spite of this, traditional nanomedicine faces major obstacles, such as blood–brain barriers, low concentrations at target sites, and rapid removal from the body. Exosomes as natural extracellular vesicles contain special bioactive molecules for cell-to-cell communications and nervous tissue function, which could overcome the challenges of nanoparticles. Most recently, microRNAs, long noncoding RNA, and circulating RNA of exosomes have been appealing because of their critical effect on the molecular pathway of target cells. In this review, we have summarized the important role of exosomes of noncoding RNAs in the occurrence of brain diseases.

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“…Additionally, recombinant Wnt3a treatment largely but not completely recapitulated the effects of MSCs and improved performance in behavioral tasks that require hippocampal neurogenesis [ 182 ]. Furthermore, administration of Zeb2/Axin2-enriched exosomes derived from MSCs transfected with a Zeb2/Axin2 overexpression plasmid to MCAO rats exhibited a significant increase in the total number of BrdU- and NeuN-positive cells in the hippocampus [ 184 ].…”

Section: Mesenchymal Stem Cells Can Open the Plasticity Window In Per...mentioning

confidence: 99%

Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells

Kot

Neglur

Pietraszewska

et al. 2022

Cells

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The hippocampus is one of the few privileged regions (neural stem cell niche) of the brain, where neural stem cells differentiate into new neurons throughout adulthood. However, dysregulation of hippocampal neurogenesis with aging, injury, depression and neurodegenerative disease leads to debilitating cognitive impacts. These debilitating symptoms deteriorate the quality of life in the afflicted individuals. Impaired hippocampal neurogenesis is especially difficult to rescue with increasing age and neurodegeneration. However, the potential to boost endogenous Wnt signaling by influencing pathway modulators such as receptors, agonists, and antagonists through drug and cell therapy-based interventions offers hope. Restoration and augmentation of hampered Wnt signaling to facilitate increased hippocampal neurogenesis would serve as an endogenous repair mechanism and contribute to hippocampal structural and functional plasticity. This review focuses on the possible interaction between neurogenesis and Wnt signaling under the control of antidepressants and mesenchymal stem cells (MSCs) to overcome debilitating symptoms caused by age, diseases, or environmental factors such as stress. It will also address some current limitations hindering the direct extrapolation of research from animal models to human application, and the technical challenges associated with the MSCs and their cellular products as potential therapeutic solutions.

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Zeb2/Axin2-Enriched BMSC-Derived Exosomes Promote Post-Stroke Functional Recovery by Enhancing Neurogenesis and Neural Plasticity

Cited by 29 publications

References 51 publications

Potential Role of Exosomes in Ischemic Stroke Treatment

Potential Role of Exosomes in Ischemic Stroke Treatment

Exosomes as Neurological Nanosized Machines

Boosting Neurogenesis in the Adult Hippocampus Using Antidepressants and Mesenchymal Stem Cells

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