2022
DOI: 10.1016/j.tig.2022.01.002
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Zebrafish and idiopathic scoliosis: the ‘unknown knowns’

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Cited by 4 publications
(4 citation statements)
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“…Moreover, identifying the pathogenic genes will also provide the potential for the treatment of the disease. 27 Our study showed that although there are not many articles on this topic among the articles with the largest number of citations, there are 5 articles related to this topic among the 25 articles with the strongest citation burst. This means that research on the genetics and molecular basis of CFM will always have a certain impact after they have been published.…”
Section: Genetic and Pathogenesis Basis Of Cfmmentioning
confidence: 55%
See 1 more Smart Citation
“…Moreover, identifying the pathogenic genes will also provide the potential for the treatment of the disease. 27 Our study showed that although there are not many articles on this topic among the articles with the largest number of citations, there are 5 articles related to this topic among the 25 articles with the strongest citation burst. This means that research on the genetics and molecular basis of CFM will always have a certain impact after they have been published.…”
Section: Genetic and Pathogenesis Basis Of Cfmmentioning
confidence: 55%
“…Recently, gene therapy has been applied in clinics, especially for single-gene defective diseases. Moreover, identifying the pathogenic genes will also provide the potential for the treatment of the disease 27 . Our study showed that although there are not many articles on this topic among the articles with the largest number of citations, there are 5 articles related to this topic among the 25 articles with the strongest citation burst.…”
Section: Discussionmentioning
confidence: 68%
“…1,2 Idiopathic scoliosis has a multifactorial etiology involving deficits in postural control by the central nervous system (CNS), hormonal components, polygenic inheritance, biomechanical spinal disorders, anomalous skeletal muscle conditions, and collagen disturbances. 3,4 The therapeutic management of idiopathic scoliosis is extremely complex. The medical approach selection relies on the angular values of the spinal curvatures, progressiveness level, and skeletal maturation.…”
Section: Introductionmentioning
confidence: 99%
“…1,2 A escoliose idiopática possui etiologia multifatorial estando envolvidos déficits de controle postural pelo Sistema Nervoso Central (SNC), componentes hormonais, herança poligênica, bem como distúrbios biomecânicos da coluna e condições anômalas da musculatura esquelética e alterações do colágeno. 3,4 Observa-se que o manejo terapêutico dos quadros de escoliose idiopática é extremamente complexo, comumente são estabelecidos valores angulares das curvas da coluna vertebral, nível de progressividade e maturação esquelética para definição de conduta médica. Curvaturas entre 10°e 25°são descritas como de "observação," entre 25°e 40°comumente são condições que podem requerer uso de gesso, órteses corretivas,1 enquanto curvaturas que ultrapassam 40°a 45°são elegíveis para abordagem cirúrgica.…”
Section: Introductionunclassified