Zebrafish as a Model for Neurological Disorders

Soussi-Yanicostas, Nadia

doi:10.3390/ijms23084321

Cited by 8 publications

(6 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zebrafish are now a choice model to test memory and learning along with visual discrimination. 51 Memory and learning are often analyzed alongside visual discrimination using a T-maze apparatus. Colwill et al 45 provided the basis for this model using three visual discrimination experiments.…”

Section: Resultsmentioning

confidence: 99%

“…[47][48][49] Recently, zebrafish have emerged as an effective model of cognitive function and have shown promise in advancing the field by uncovering unknown mechanisms of neurological disease in humans. 50,51 Numerous publications have shown evidence that zebrafish are effective models for investigating human neuroscience, as they strike a remarkable balance between system complexity and practical simplicity. 48,50,52,53 Furthermore, these models show evidence for delving into the realm of toxicological investigation.…”

Section: Convenience and Feasibilitymentioning

confidence: 99%

Section: Memory and Learningmentioning

confidence: 99%

See 2 more Smart Citations

An Evaluation of Zebrafish, an Emerging Model Analyzing the Effects of Toxicants on Cognitive and Neuromuscular Function

Clevenger,

Paz,

Stafford

et al. 2023

Int J Toxicol

View full text Add to dashboard Cite

An emerging alternative to conventional animal models in toxicology research is the zebrafish. Their accelerated development, regenerative capacity, transparent physical appearance, ability to be genetically manipulated, and ease of housing and care make them feasible and efficient experimental models. Nonetheless, their most esteemed asset is their 70% (+) genetic similarity with the human genome, which allows the model to be used in a variety of clinically relevant studies. With these attributes, we propose the zebrafish is an excellent model for analyzing cognitive and neuromuscular responses when exposed to toxicants. Neurocognition can be readily analyzed using visual discrimination, memory and learning, and social behavior testing. Neuromuscular function can be analyzed using techniques such as the startle response, assessment of activity level, and evaluation of critical swimming speed. Furthermore, selectively mutated zebrafish is another novel application of this species in behavioral and pharmacological studies, which can be exploited in toxicological studies. There is a critical need in biomedical research to discover ethical and cost-effective methods to develop new products, including drugs. Through mutagenesis, zebrafish models have become key in meeting this need by advancing the field in numerous areas of biomedical research.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Convenience and Feasibilitymentioning

confidence: 99%

See 1 more Smart Citation

An Evaluation of Zebrafish, an Emerging Model Analyzing the Effects of Toxicants on Cognitive and Neuromuscular Function

Clevenger,

Paz,

Stafford

et al. 2023

Int J Toxicol

View full text Add to dashboard Cite

show abstract

“…Complementing studies in the wild with those in captivity could be done with the same species, if it is amenable to conditions in captivity (at least temporarily) or by using closely related species with established husbandry, and whose neurology and behaviour have already been extensively studied (Jeibmann & Paulus, 2009; Xie et al ., 2010; Chesselet & Carmichael, 2012; Nout et al ., 2012; Soussi‐Yanicostas, 2022). It might also be possible to work with zoo animals, as they are highly diverse in terms of species and individuals [ ca .…”

Section: Validating Physiological Markers As Welfare Indicators In Th...mentioning

confidence: 99%

Capturing wild animal welfare: a physiological perspective

Beaulieu

2023

Biological Reviews

View full text Add to dashboard Cite

Affective states, such as emotions, are presumably widespread across the animal kingdom because of the adaptive advantages they are supposed to confer. However, the study of the affective states of animals has thus far been largely restricted to enhancing the welfare of animals managed by humans in non‐natural contexts. Given the diversity of wild animals and the variable conditions they can experience, extending studies on animal affective states to the natural conditions that most animals experience will allow us to broaden and deepen our general understanding of animal welfare. Yet, this same diversity makes examining animal welfare in the wild highly challenging. There is therefore a need for unifying theoretical frameworks and methodological approaches that can guide researchers keen to engage in this promising research area. The aim of this article is to help advance this important research area by highlighting the central relationship between physiology and animal welfare and rectify its apparent oversight, as revealed by the current scientific literature on wild animals. Moreover, this article emphasises the advantages of including physiological markers to assess animal welfare in the wild (e.g. objectivity, comparability, condition range, temporality), as well as their concomitant limitations (e.g. only access to peripheral physiological markers with complex relationships with affective states). Best‐practice recommendations (e.g. replication and multifactorial approaches) are also provided to allow physiological markers to be used most effectively and appropriately when assessing the welfare of animals in their natural habitat. This review seeks to provide the foundation for a new and distinct research area with a vast theoretical and applied potential: wild animal welfare physiology.

show abstract

“…As an outstanding vertebrate model, the zebrafish ( Danio rerio ) shows high homology to the human brain, possessing conserved signal transduction pathways and a mature genetic operating system [8]. Zebrafish have been increasingly employed in the investigation of a wide variety of human diseases, especially sleep disorders and other neuropsychiatric diseases [9].…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rg1 alleviates sleep deprivation-induced learning and memory impairment by inhibiting excessive neuronal apoptosis in zebrafish

Zhang

Ran

et al. 2023

NeuroReport

View full text Add to dashboard Cite

Sleep deprivation impairs learning and memory. The neuroprotective function of ginsenoside Rg1 (Rg1) has been reported. This study aimed to investigate the alleviative effect and underlying mechanism of action of Rg1 on learning and memory deficits induced by sleep deprivation. Using 72 h of LED light to establish sleep deprivation model and treatment with Rg1-L (0.5 mg/ml), Rg1-H (1 mg/ml), and melatonin (positive control, 0.25 mg/ml), we investigated the behavioral performance of sleep deprivation zebrafish through 24 h autonomous movement tracking, a novel tank diving test, and a T-maze test. Brain injuries and ultrastructural changes were observed, brain water content was measured, and apoptotic events were analyzed using terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling staining. The oxidation-associated biomarkers superoxide dismutase, catalase, and glutathione peroxidase activity and lipid peroxidation product malondialdehyde content were detected. Real-time PCR and western blotting were performed to detect the levels of apoptotic molecules (Bax, caspase-3, and Bcl-2). Rg1-treatment was observed to improve the behavioral performance of sleep-deprivation fish, alleviate brain impairment, and increase oxidative stress-related enzyme activity. Rg1 can effectively exhibit neuroprotective functions and improve learning and memory impairments caused by sleep deprivation, which could be mediated by the Bcl-2/Bax/caspase-3 apoptotic signaling pathway (see Supplementary Video Abstract, Supplemental digital content, http://links.lww.com/WNR/A702 which demonstrates our research objectives, introduction overview of Rg1, and main direction of future research).

show abstract

Zebrafish as a Model for Neurological Disorders

Abstract: Over the past two decades, the simplicity and the versatility of the zebrafish (Danio rerio) have helped make it one of the main animal models used to address an increasing number of issues, from fundamental research to clinical investigations, drug discovery [...]

Cited by 8 publications

References 14 publications

An Evaluation of Zebrafish, an Emerging Model Analyzing the Effects of Toxicants on Cognitive and Neuromuscular Function

An Evaluation of Zebrafish, an Emerging Model Analyzing the Effects of Toxicants on Cognitive and Neuromuscular Function

Capturing wild animal welfare: a physiological perspective

Ginsenoside Rg1 alleviates sleep deprivation-induced learning and memory impairment by inhibiting excessive neuronal apoptosis in zebrafish

Contact Info

Product

Resources

About