Zebrafish as a Model to Study Retinoic Acid Signaling in Development and Disease

Hawkins, Matthew R.; Wingert, Rebecca A.

doi:10.3390/biomedicines11041180

Cited by 6 publications

(1 citation statement)

References 251 publications

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“…Previous studies have suggested that atRA plays an important regulatory role in vertebrate development and that the production of a small amount of atRA is necessary to maintain normal vertebrate development . In the present study, the ontogeny, tissue structure, and function of marine medaka in the LL group were not significantly affected, indicating that under normal light, moderate RAL produced by algal cells was transmitted and transformed from the food chain and that atRA did not cause toxic damage to the fish.…”

Section: Discussioncontrasting

confidence: 49%

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Liu,

Xie,

Xiao

et al. 2024

Environ. Sci. Technol.

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Marine microalgae serve as an aquaculture bait. To enhance algal cell growth and breeding profits, high-intensity light conditions are standard for cultivating bait microalgae, potentially altering microalgal metabolite production. This research revealed that Thalassiosira pseudonana, when subjected to high-intensity light conditions, accumulated significant quantities of retinal (RAL) that transferred through the food chain and transformed into alltrans retinoic acid (atRA) in marine medaka. The study further explored the toxic effects on individual fish and specific tissues, as well as the mechanisms behind this toxicity. The accumulation of atRA in the liver, intestine, and spinal column resulted in structural damage and tissue inflammation, as well as oxidative stress. It also down-regulated the gene transcription levels of key pathways involved in immune function and growth. Furthermore, it disrupted the homeostasis of the intestinal microbial communities. The implications for wildlife and human health, which are influenced by the regulation of microalgal metabolite accumulation and their transfer via the food chain, require further investigation and could hold broader significance.

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Section: Discussioncontrasting

confidence: 49%

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Liu,

Xie,

Xiao

et al. 2024

Environ. Sci. Technol.

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Differential retinoic acid sensitivity of oral and pharyngeal teeth in medaka (Oryzias latipes) supports the importance of pouch–cleft contacts in pharyngeal tooth initiation

Larionova,

Huysseune

2024

Developmental Dynamics

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BackgroundPrevious studies have claimed that pharyngeal teeth in medaka (Oryzias latipes) are induced independent of retinoic acid (RA) signaling, unlike in zebrafish (Danio rerio). In zebrafish, pharyngeal tooth formation depends on a proper physical contact between the embryonic endodermal pouch anterior to the site of tooth formation, and the adjacent ectodermal cleft, an RA‐dependent process. Here, we test the hypothesis that a proper pouch–cleft contact is required for pharyngeal tooth formation in embryonic medaka, as it is in zebrafish. We used 4‐[diethylamino]benzaldehyde (DEAB) to pharmacologically inhibit RA production, and thus pouch–cleft contacts, in experiments strictly controlled in time, and analyzed these using high‐resolution imaging.ResultsPharyngeal teeth in medaka were present only when the corresponding anterior pouch had reached the ectoderm (i.e., a physical pouch–cleft contact established), similar to the situation in zebrafish. Oral teeth were present even when the treatment started approximately 4 days before normal oral tooth appearance.ConclusionsRA dependency for pharyngeal tooth formation is not different between zebrafish and medaka. We propose that the differential response to DEAB of oral versus pharyngeal teeth in medaka could be ascribed to the distinct germ layer origin of the epithelia involved in tooth formation in these two regions.

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Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish

Chen,

Ran,

Chen

et al. 2024

Biochemistry and Biophysics Reports

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Zebrafish as a Model to Study Retinoic Acid Signaling in Development and Disease

Cited by 6 publications

References 251 publications

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Conversion of Retinoids along the Marine Food Chain Contributes to Adverse Impacts on the Spine, Liver, and Intestinal Health of the Marine Medaka (Oryzias melastigma)

Differential retinoic acid sensitivity of oral and pharyngeal teeth in medaka (Oryzias latipes) supports the importance of pouch–cleft contacts in pharyngeal tooth initiation

Cxcr4a regulates heart progenitor development and cardiac rhythm in zebrafish

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