Zebrafish models of major depressive disorders

Fonseka, Trehani M.; Wen, Xiao‐Yan; Foster, Jane A.; Kennedy, Sidney H.

doi:10.1002/jnr.23639

Cited by 58 publications

(36 citation statements)

References 135 publications

(169 reference statements)

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“…Zebrafish are used to model neurodegeneration15, depression54, autism17 and schizophrenia55 among others56 and for neuropharmacological16 and neurotoxicology57 research. These disorders and interventions directly and indirectly influence synapse protein structure and function.…”

Section: Discussionmentioning

confidence: 99%

Evolution of complexity in the zebrafish synapse proteome

et al. 2017

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The proteome of human brain synapses is highly complex and is mutated in over 130 diseases. This complexity arose from two whole-genome duplications early in the vertebrate lineage. Zebrafish are used in modelling human diseases; however, its synapse proteome is uncharacterized, and whether the teleost-specific genome duplication (TSGD) influenced complexity is unknown. We report the characterization of the proteomes and ultrastructure of central synapses in zebrafish and analyse the importance of the TSGD. While the TSGD increases overall synapse proteome complexity, the postsynaptic density (PSD) proteome of zebrafish has lower complexity than mammals. A highly conserved set of ∼1,000 proteins is shared across vertebrates. PSD ultrastructural features are also conserved. Lineage-specific proteome differences indicate that vertebrate species evolved distinct synapse types and functions. The data sets are a resource for a wide range of studies and have important implications for the use of zebrafish in modelling human synaptic diseases.

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Section: Discussionmentioning

confidence: 99%

Evolution of complexity in the zebrafish synapse proteome

et al. 2017

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“…CRISPR/Cas) and automated 3D behavioural phenotyping, this makes zebrafish an ideal model to study genotype–phenotype and genotype‐drug‐phenotype relationships (Kokel et al, ; Cachat et al, ; Hwang et al, ; Stewart et al, ). Furthermore, zebrafish develop externally to the maternal organism, reach sexual maturity fast (in ~90 days) and live for ~4–5 years in the laboratory, allowing for direct and easy analyses of pathogenetic trajectories (Kalueff et al, ; Fonseka et al, ). Complementing larval models, adult zebrafish exhibit complex behaviours (Kalueff et al, ) relevant to cognition (Blaser and Vira, ; Gerlai, ), reward (Collier et al, ; von Trotha et al, ), social behaviour (Gerlai, ; Qin et al, ) and effects (Jesuthasan, ; Gerlai, ; Wang et al, ).…”

Section: Introduction: Zebrafish As An Emerging Animal Modelmentioning

confidence: 99%

Zebrafish models in neuropsychopharmacology and CNS drug discovery

Khan

Collier

Meshalkina

et al. 2017

British J Pharmacology

155

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Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized as a powerful animal model in neuropharmacology research and in vivo drug screening. Collectively, this makes zebrafish a useful tool for drug discovery and the identification of disordered molecular pathways. Here, we discuss zebrafish models of selected human neuropsychiatric disorders and drug-induced phenotypes. As well as covering a broad range of brain disorders (from anxiety and psychoses to neurodegeneration), we also summarize recent developments in zebrafish genetics and small molecule screening, which markedly enhance the disease modelling and the discovery of novel drug targets.

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“…Over the last ten years zebrafish has become an interesting model organism to study the molecular and cell biology of the vertebrate brain [ 54 , 55 ] and has emerged as a model species for translational research in various neuroscience areas, such as depressive disorders [ 56 ], neurodegeneration [ 57 ], motor neuron disease [ 58 ], autism spectrum disorders [ 59 ] and Alzheimer’s disease [ 60 ]. In addition, compared to mammals, the brain of adult zebrafish exhibits a high number of proliferative areas distributed along the ventricles of the telencephalon, diencephalon and mesencephalon [ 61 – 65 ], a feature tightly linked to the persistence of radial glial progenitors [ 61 ].…”

Section: Introductionmentioning

confidence: 99%

BDNF Expression in Larval and Adult Zebrafish Brain: Distribution and Cell Identification

Cacialli¹,

Guéguen²,

Coumailleau³

et al. 2016

PLoS ONE

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Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has emerged as an active mediator in many essential functions in the central nervous system of mammals. BDNF plays significant roles in neurogenesis, neuronal maturation and/or synaptic plasticity and is involved in cognitive functions such as learning and memory. Despite the vast literature present in mammals, studies devoted to BDNF in the brain of other animal models are scarse. Zebrafish is a teleost fish widely known for developmental genetic studies and is emerging as model for translational neuroscience research. In addition, its brain shows many sites of adult neurogenesis allowing higher regenerative properties after traumatic injuries. To add further knowledge on neurotrophic factors in vertebrate brain models, we decided to determine the distribution of bdnf mRNAs in the larval and adult zebrafish brain and to characterize the phenotype of cells expressing bdnf mRNAs by means of double staining studies. Our results showed that bdnf mRNAs were widely expressed in the brain of 7 days old larvae and throughout the whole brain of mature female and male zebrafish. In adults, bdnf mRNAs were mainly observed in the dorsal telencephalon, preoptic area, dorsal thalamus, posterior tuberculum, hypothalamus, synencephalon, optic tectum and medulla oblongata. By combining immunohistochemistry with in situ hybridization, we showed that bdnf mRNAs were never expressed by radial glial cells or proliferating cells. By contrast, bdnf transcripts were expressed in cells with neuronal phenotype in all brain regions investigated. Our results provide the first demonstration that the brain of zebrafish expresses bdnf mRNAs in neurons and open new fields of research on the role of the BDNF factor in brain mechanisms in normal and brain repairs situations.

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Zebrafish models of major depressive disorders

Cited by 58 publications

References 135 publications

Evolution of complexity in the zebrafish synapse proteome

Evolution of complexity in the zebrafish synapse proteome

Zebrafish models in neuropsychopharmacology and CNS drug discovery

BDNF Expression in Larval and Adult Zebrafish Brain: Distribution and Cell Identification

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