Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine

Webb, Katharine J; Norton, William; Trümbach, Dietrich; Meijer, Annemarie H.; Ninkovic, Jovica; Topp, Stefanie; Heck, Daniel W.; Marr, Carsten; Wurst, Wolfgang; Theis, Fabian J.; Spaink, Herman P.; Bally‐Cuif, Laure

doi:10.1186/gb-2009-10-7-r81

Cited by 75 publications

(65 citation statements)

References 110 publications

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“…Recent experiments in both larval and adult zebrafish have tested the behavioral effects of psychotropic compounds, including drugs of abuse (Gerlai et al, 2000;Darland and Dowling, 2001;Bilotta et al, 2002;Dlugos and Rabin, 2003;Lockwood et al, 2004;Gerlai et al, 2006;Lau et al, 2006;Gerlai et al, 2008;Kily et al, 2008;Lopez-Patino et al, 2008a,b;Egan et al, 2009;Fernandes and Gerlai, 2009;Gerlai et al, 2009;MacPhail et al, 2009;Webb et al, 2009;Blaser et al, 2010;Cachat et al, 2010;Irons et al, 2010;Sackerman et al, 2010;Wong et al, 2010;Dlugos et al, 2011;Mathur and Guo, 2011;Maximino et al, 2011), anxiolytics and anxiogenics (Levin et al, 2007;Bencan and Levin, 2008;Bencan et al, 2009;Egan et al, 2009;Lau et al, 2011;Maximino et al, 2011), anti-psychotics (Giacomini et al, 2006;Boehmler et al, 2007), hallucinogens (Swain et al, 2004;Blank et al, 2009;Grossman et al, 2010;Seibt et al, 2010), and sedatives (Zhdanova et al, 2001;Ruuskanen et al, 2005;Renier et al, 2007). Conditioned placed preference testing in adults has been used to identify zeb...…”

Section: Probing Zebrafish Behavior With Small Moleculesmentioning

confidence: 99%

“…Conditioned placed preference testing in adults has been used to identify zebrafish mutants with defects in cocaine (Darland and Dowling, 2001) or amphetamine (Webb et al, 2009) reward pathways. The effects of both acute and chronic exposure of ethanol have been extensively studied in adult locomotion (Gerlai et al, 2000(Gerlai et al, , 2008, reward (Kily et al, 2008), tolerance (Dlugos and Rabin, 2003;Blaser et al, 2010;Dlugos et al, 2011), withdrawal Cachat et al, 2010), aggression (Gerlai et al, 2000), and anxiety tests (Gerlai et al, 2006;Fernandes and Gerlai, 2009;Sackerman et al, 2010;Wong et al, 2010;Mathur and Guo, 2011;Maximino et al, 2011).…”

Section: Probing Zebrafish Behavior With Small Moleculesmentioning

confidence: 99%

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Behavioral screening for neuroactive drugs in zebrafish

Rihel

Schier

2012

Developmental Neurobiology

110

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The larval zebrafish has emerged asa vertebrate model system amenable to small molecule screens for probing diverse biological pathways. Two large-scale small molecule screens examined the effects of thousands of drugs on larval zebrafish sleep/wake and photomotor response behaviors. Both screens identified hundreds of molecules that altered zebrafish behavior in distinct ways. The behavioral profiles induced by these small molecules enabled the clustering of compounds according to shared phenotypes. This approach identified regulators of sleep/wake behavior and revealed the biological targets for poorly characterized compounds. Behavioral screening for neuroactive small molecules in zebrafish is an attractive complement to in vitro screening efforts, because the complex interactions in the vertebrate brain can only be revealed in vivo.

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Section: Probing Zebrafish Behavior With Small Moleculesmentioning

confidence: 99%

Section: Probing Zebrafish Behavior With Small Moleculesmentioning

confidence: 99%

Behavioral screening for neuroactive drugs in zebrafish

Rihel

Schier

2012

Developmental Neurobiology

110

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“…Behavioral assays define changes induced by drug exposure and enable differential molecular analysis of the resulting transcriptional (i.e., gene expression) and epigenetic states (Kane, Konu, Ma, & Li, 2004;Kumar et al, 2005;Levine et al, 2005;Nestler, 2008;Renthal et al, 2007;Romieu et al, 2008;Shen et al, 2008). As the reinforcing properties of addictive drugs are highly conserved, behavioral assays have been adapted to zebrafish to study addiction to cocaine (Darland & Dowling, 2001), ethanol (Lockwood, Bjerke, Kobayashi, & Guo, 2004;Peng et al, 2009), amphetamines (Ninkovic & Bally-Cuif, 2006;Webb et al, 2009), and opiates (Bretaud et al, 2007;Lau, Bretaud, Huang, Lin, & Guo, 2006;Sanchez-Simon & Rodriguez, 2008). A broad perspective review of zebrafish use in the study of addiction and other neuropsychiatric disorders has been published (Mathur & Guo, 2010).…”

Section: Drug Addiction and Dependencementioning

confidence: 99%

Zebrafish for the Study of the Biological Effects of Nicotine

Klee

Ebbert

Schneider

et al. 2011

Nicotine & Tobacco Research

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Introduction: Zebrafish are emerging as a powerful animal model for studying the molecular and physiological effects of nicotine exposure. The zebrafish have many advantageous physical characteristics, including small size, high fecundity rates, and externally developing transparent embryos. When combined with a battery of molecular-genetic tools and behavioral assays, these attributes enable studies to be conducted that are not practical using traditional animal models. Methods:We reviewed the literature on the application of the zebrafish model as a preclinical model to study the biological effects of nicotine exposure. Results:The identified studies used zebrafish to examine the effects of nicotine exposure on early development, addiction, anxiety, and learning. The methods used included green fluorescent protein-labeled proteins to track in vivo nicotine-altered neuron development, nicotine-conditioned place preference, and locomotive sensitization linked with high-throughput molecular and genetic screens and behavioral models of learning and stress response to nicotine. Data are presented on the complete homology of all known human neural nicotinic acetylcholine receptors in zebrafish and on the biological similarity of human and zebrafish dopaminergic signaling.Conclusions: Tobacco dependence remains a major health problem worldwide. Further understanding of the molecular effects of nicotine exposure and genetic contributions to dependence may lead to improvement in patient treatment strategies. While there are limitations to the use of zebrafish as a preclinical model, it should provide a valuable tool to complement existing model systems. The reviewed studies demonstrate the enormous opportunity zebrafish have to advance the science of nicotine and tobacco research.

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“…[1][2][3] Zebrafish (Danio rerio) are rapidly emerging as a useful species for studying normal or pathological behaviors [4][5][6][7][8][9][10] and modeling complex brain disorders [11][12][13][14][15][16][17] (Table 1). The zebrafish genome is fully characterized, and their physiology and neuroanatomy parallel those of humans.…”

mentioning

confidence: 99%

“…Place preference: The tendency to establish a preferred location in which the fish spends more time. Can be induced by drugs (e.g., in conditioned place preference paradigms, CPP 9,123,[135][136][137][138][139] ), repeated administration of food/food odors, 73 social reward, 13 or be based on natural behaviors (e.g., homebase formation 113 ) or preferences (e.g., depth preference, scototaxis, thigmotaxis 31,59,60 ). 1.120.…”

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confidence: 99%

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

et al. 2013

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Zebrafish (Danio rerio) are rapidly gaining popularity in translational neuroscience and behavioral research. Physiological similarity to mammals, ease of genetic manipulations, sensitivity to pharmacological and genetic factors, robust behavior, low cost, and potential for high-throughput screening contribute to the growing utility of zebrafish models in this field. Understanding zebrafish behavioral phenotypes provides important insights into neural pathways, physiological biomarkers, and genetic underpinnings of normal and pathological brain function. Novel zebrafish paradigms continue to appear with an encouraging pace, thus necessitating a consistent terminology and improved understanding of the behavioral repertoire. What can zebrafish 'do', and how does their altered brain function translate into behavioral actions? To help address these questions, we have developed a detailed catalog of zebrafish behaviors (Zebrafish Behavior Catalog, ZBC) that covers both larval and adult models. Representing a beginning of creating a more comprehensive ethogram of zebrafish behavior, this effort will improve interpretation of published findings, foster cross-species behavioral modeling, and encourage new groups to apply zebrafish neurobehavioral paradigms in their research. In addition, this glossary creates a framework for developing a zebrafish neurobehavioral ontology, ultimately to become part of a unified animal neurobehavioral ontology, which collectively will contribute to better integration of biological data within and across species.

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Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine

Abstract: Transcriptome analysis of a zebrafish mutant that does not respond to amphetamine identifies a network of coordinated gene regulation that may underlie the susceptibility to addiction.

Cited by 75 publications

References 110 publications

Behavioral screening for neuroactive drugs in zebrafish

Behavioral screening for neuroactive drugs in zebrafish

Zebrafish for the Study of the Biological Effects of Nicotine

Towards a Comprehensive Catalog of Zebrafish Behavior 1.0 and Beyond

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