Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Graham, David J.; Wylie, Douglas R.

doi:10.1523/jneurosci.0197-12.2012

Cited by 51 publications

(71 citation statements)

References 68 publications

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“…3). Interestingly, in the vestibulocerebellum of birds, neighboring zebrin-positive and zebrin-negative modules have been found to respond best to the same pattern of optic flow in 3D space (Graham and Wylie 2012). One could imagine that antagonistic movements characteristic of flying may have different temporal and thereby modulational demands depending on their relation with gravity, engaging the zebrin-positive and -negative modules under different circumstances.…”

Section: Discussionmentioning

confidence: 99%

“…These zebra-like patterns of protein distribution appear to be present in the cerebellum of all birds and mammals (Brochu et al 1990;Sillitoe et al 2003;Chung et al 2007;Apps and Hawkes 2009;Graham and Wylie 2012), and in many cases they largely correspond to the organization of the olivocerebellar modules (Figs. 2,3A-C) (Sugihara andShinoda 2004, 2007;Voogd and Ruigrok 2004;Pijpers et al 2006;Sugihara et al 2009;Sugihara 2011).…”

Section: Intrinsic Differences Among Cerebellar Modulesmentioning

confidence: 97%

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Motor Learning and the Cerebellum

Zeeuw

Brinke²

2015

Cold Spring Harb Perspect Biol

202

168

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Although our ability to store semantic declarative information can nowadays be readily surpassed by that of simple personal computers, our ability to learn and express procedural memories still outperforms that of supercomputers controlling the most advanced robots. To a large extent, our procedural memories are formed in the cerebellum, which embodies more than two-thirds of all neurons in our brain. In this review, we will focus on the emerging view that different modules of the cerebellum use different encoding schemes to form and express their respective memories. More specifically, zebrin-positive zones in the cerebellum, such as those controlling adaptation of the vestibulo-ocular reflex, appear to predominantly form their memories by potentiation mechanisms and express their memories via rate coding, whereas zebrin-negative zones, such as those controlling eyeblink conditioning, appear to predominantly form their memories by suppression mechanisms and express their memories in part by temporal coding using rebound bursting. Together, the different types of modules offer a rich repertoire to acquire and control sensorimotor processes with specific challenges in the spatiotemporal domain.

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Section: Discussionmentioning

confidence: 99%

Section: Intrinsic Differences Among Cerebellar Modulesmentioning

confidence: 97%

Motor Learning and the Cerebellum

Zeeuw

Brinke²

2015

Cold Spring Harb Perspect Biol

202

168

View full text Add to dashboard Cite

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“…4 ) that divides the P2+ stripe into medial and lateral halves were present in both tinamous and pigeons. In pigeons, the ZII stripes within the VbC correspond to specific patterns of optic flow, such that each optic flow sagittal zone encompasses an adjacent ZII+/-stripe pair [Graham and Wylie, 2012;Pakan et al, 2010Wylie, 2013]. The VbC is a site for the integration of vestibular [Wilson et al, 1974], optic flow [Wylie andFrost, 1991, 1993;, and cutaneous information [Schulte and Necker, 1998] and it is critical for mediating compensatory head, body, and eye movements to facilitate retinal image stabilization [Waespe and Henn, 1987].…”

Section: Discussionmentioning

confidence: 99%

Zebrin II Expression in the Cerebellum of a Paleognathous Bird, the Chilean Tinamou (Nothoprocta perdicaria)

Corfield

Kolominsky²,

Marı́n³

et al. 2015

Brain Behav Evol

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Zebrin II (ZII) is a glycolytic enzyme expressed in cerebellar Purkinje cells. In both mammals and birds, ZII is expressed heterogeneously, such that there are sagittal stripes of Purkinje cells with a high ZII expression (ZII+) alternating with stripes of Purkinje cells with little or no expression (ZII-). To date, ZII expression studies are limited to neognathous birds: pigeons (Columbiformes), chickens (Galliformes), and hummingbirds (Trochilidae). These previous studies divided the avian cerebellum into 5 transverse regions based on the pattern of ZII expression. In the lingular region (lobule I) all Purkinje cells are ZII+. In the anterior region (lobules II-V) there are 4 pairs of ZII+/- stripes. In the central region (lobules VI-VIII) all Purkinje cells are ZII+. In the posterior region (lobules VIII-IX) there are 5-7 pairs of ZII+/- stripes. Finally, in the nodular region (lobule X) all Purkinje cells are ZII+. As the pattern of ZII stripes is quite similar in these disparate species, it appears that it is highly conserved. However, it has yet to be studied in paleognathous birds, which split from the neognaths over 100 million years ago. To better understand the evolution of cerebellar compartmentation in birds, we examined ZII immunoreactivity in a paleognath, the Chilean tinamou (Nothoprocta perdicaria). In the tinamou, Purkinje cells expressed ZII heterogeneously such that there were sagittal ZII+ and ZII- stripes of Purkinje cells, and this pattern of expression was largely similar to that observed in neognathous birds. For example, all Purkinje cells in the lingular (lobule I) and nodular (lobule X) regions were ZII+, and there were 4 pairs of ZII+/- stripes in the anterior region (lobules II-V). In contrast to neognaths, however, ZII was expressed in lobules VI-VII as a series of sagittal stripes in the tinamou. Also unlike in neognaths, stripes were absent in lobule IXab, and all Purkinje cells expressed ZII in the tinamou. The differences in ZII expression between the tinamou and neognaths could reflect behavior, but the general similarity of the expression patterns across all bird species suggests that ZII stripes evolved early in the avian phylogenetic tree.

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“…It has been shown in pigeons that in the flocculus, Purkinje cells process optic flow resulting from self-rotation, whereas those in the uvula [i.e. the medial VbC encompassing stripes P1+/-to P2+/-, Graham and Wylie, 2012] process optic flow resulting from self-translation [see review in Wylie, 2013]. One interpretation of the ZII expression pattern in folium IXcd of kiwi is that the processing of self-rotation is somehow modified.…”

Section: Visual Ecology and Cerebellar Architecturementioning

confidence: 99%

Is Cerebellar Architecture Shaped by Sensory Ecology in the New Zealand Kiwi (Apteryx mantelli)?

Corfield

Kolominsky²,

Craciun³

et al. 2016

Brain Behav Evol

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Among some mammals and birds, the cerebellar architecture appears to be adapted to the animal's ecological niche, particularly their sensory ecology and behavior. This relationship is, however, not well understood. To explore this, we examined the expression of zebrin II (ZII) in the cerebellum of the kiwi (Apteryx mantelli), a fully nocturnal bird with auditory, tactile, and olfactory specializations and a reduced visual system. We predicted that the cerebellar architecture, particularly those regions receiving visual inputs and those that receive trigeminal afferents from their beak, would be modified in accordance with their unique way of life. The general stripe-and-transverse region architecture characteristic of birds is present in kiwi, with some differences. Folium IXcd was characterized by large ZII-positive stripes and all Purkinje cells in the flocculus were ZII positive, features that resemble those of small mammals and suggest a visual ecology unlike that of other birds. The central region in kiwi appeared reduced or modified, with folium IV containing ZII+/- stripes, unlike that of most birds, but similar to that of Chilean tinamous. It is possible that a reduced visual system has contributed to a small central region, although increased trigeminal input and flightlessness have undoubtedly played a role in shaping its architecture. Overall, like in mammals, the cerebellar architecture in kiwi and other birds may be substantially modified to serve a particular ecological niche, although we still require a larger comparative data set to fully understand this relationship.

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Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Cited by 51 publications

References 68 publications

Motor Learning and the Cerebellum

Motor Learning and the Cerebellum

Zebrin II Expression in the Cerebellum of a Paleognathous Bird, the Chilean Tinamou <b><i>(Nothoprocta perdicaria)</i></b>

Is Cerebellar Architecture Shaped by Sensory Ecology in the New Zealand Kiwi <b><i>(Apteryx mantelli)</i></b><b>?</b>

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