Zedoarondiol inhibits atherosclerosis by regulating monocyte migration and adhesion via CXCL12/CXCR4 pathway

Chai, Hua; Qu, Hua; He, Shan; Song, Lei; Yu, Yang; Huang, Hongbo; Shi, Dazhuo

doi:10.1016/j.phrs.2022.106328

Cited by 13 publications

(7 citation statements)

References 31 publications

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“…The LY6Cs (Ly6c1 and Ly6c2) are predominantly expressed in monocyte-derived inflammatory macrophages. 56,72 Another activated macrophage was also defined as an inflammatory macrophage by enrichment of interferon-stimulated genes, such as Ifit3 and Isg15. 73 From the perspective of lipid metabolism, inflammatory macrophages were designated as nonfoamy macrophages with a dominant pro-inflammatory gene profile.…”

Section: Atherosclerotic Inflammatory Macrophagesmentioning

confidence: 99%

“…Several inflammasome‐related genes can also be detected, along with pro‐inflammatory chemokines ( Cxcl9 , Cxcl10 , and Cxcl12 ). The LY6Cs ( Ly6c1 and Ly6c2 ) are predominantly expressed in monocyte‐derived inflammatory macrophages 56,72 . Another activated macrophage was also defined as an inflammatory macrophage by enrichment of interferon‐stimulated genes, such as Ifit3 and Isg15 73 …”

Section: General Review Of Macrophage Subtypes In Micementioning

confidence: 99%

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Heterogeneity of macrophages in atherosclerosis revealed by single‐cell RNA sequencing

Zhang

Liu

et al. 2023

The FASEB Journal

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Technology at the single-cell level has advanced dramatically in characterizing molecular heterogeneity. These technologies have enabled cell subtype diversity to be seen in all tissues, including atherosclerotic plaques. Critical in atherosclerosis pathogenesis and progression are macrophages. Previous studies have only How to cite this article: Yu L, Zhang Y, Liu C, et al. Heterogeneity of macrophages in atherosclerosis revealed by single-cell RNA sequencing.

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Section: Atherosclerotic Inflammatory Macrophagesmentioning

confidence: 99%

Section: General Review Of Macrophage Subtypes In Micementioning

confidence: 99%

Heterogeneity of macrophages in atherosclerosis revealed by single‐cell RNA sequencing

Zhang

Liu

et al. 2023

The FASEB Journal

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“…CXCL12 was another specific marker for synthetic VSMCs revealed by our study, which is also known as SDF1, a chemokine with 2 receptors including CXCR4 and ACKR 3 and mainly expresses in FBs, stromal cells and epithelial cells (Chai et al 2022 ). As a highly conserved 7 transmembrane regions protein, CXCL12 is the only ligand for CXCR4, which induces the activation of PI3K-Akt signaling pathway and regulates the phosphorylation of ERK1/2 to activate NF-κB and mTOR signaling pathways, thereby regulating cell growth and proliferation (Wu et al 2010 ).…”

Section: Discussionmentioning

confidence: 74%

“…Phenotypic alteration between synthetic and contractile VSMCs is a key biological process in the maintenance of aortic homeostasis, but there are no specific surface markers to distinguish synthetic and contractile VSMCs whereby performing further studies (Zhang et al 2020 ). Neutrophil infiltration is a pivotal pathological feature in ATAD, which might be recruited by adventitial-derived CXCL1/CSF3 whereby triggering ATAD via secretion of MMP9 (Anzai et al 2015 ; Chai et al 2022 ). Fibroblast is the major cellular component of adventitia and play roles in regulating extracellular matrix (ECM) organization, maintaining the integrity of tissues and immune response (Yun et al 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Jin

Zhao

et al. 2022

Mol Med

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Background Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain less studied. Methods Single-cell RNA sequencing was performed including 5 patients with ATAD and 4 healthy controls. Immunohistochemistry and immunofluorescence were used to verify the findings. Results We got 8 cell types from human ascending aorta and identified 50 subpopulations including vascular smooth muscle cells (VSMCs), endothelial cells, fibroblasts, neutrophils, monocytes and macrophages. Six transmembrane epithelial antigen of prostate 4 metalloreductase (STEAP4) was identified as a new marker of synthetic VSMCs. CytoTRACE identified subpopulations with higher differentiation potential in specified cell types including synthetic VSMCs, enolase 1+ fibroblasts and myeloid-derived neutrophils. Synthetic VSMCs-derived C-X-C motif chemokine ligand 12 (CXCL12) might interact with neutrophils and fibroblasts via C-X-C motif chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3), respectively, which might recruit neutrophils and induce transdifferentitation of fibroblasts into synthetic VSMCs. Conclusion We characterized signatures of different cell types in normal and dissected human ascending aorta and identified a new marker for isolation of synthetic VSMCs. Moreover, we proposed a potential mechanism that synthetic VSMCs might interact with neutrophils and fibroblasts via CXCL12-CXCR4/ACKR3 axis whereby deteriorating the progression of ATAD, which might provide new insights to better understand the development and progression of ATAD.

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“…Beyond the anti-platelet aggregation effects, sesquiterpenoids potentially exert influences on various other aspects of cardiovascular health, including vasodilation, combating atherosclerosis, alleviating cerebral ischemia-reperfusion injury, mitigating myocardial ischemia-reperfusion injury, and intervening with restenosis [1,33,[121][122][123][124][125].…”

Section: Effects On Cardiovascular Systemmentioning

confidence: 99%

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

Cui,

Li,

Liu

et al. 2024

Biomolecules

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Curcumae Rhizoma, a traditional Chinese medicine with a wide range of pharmacological activities, is obtained from the dried rhizomes of Curcuma phaeocaulis VaL., Curcuma kwangsiensis S. G. Lee et C. F. Liang, and Curcuma wenyujin Y. H. Chen et C. Ling. Sesquiterpenoids and curcuminoids are found to be the main constituents of Curcumae Rhizoma. Sesquiterpenoids are composed of three isoprene units and are susceptible to complex transformations, such as cyclization, rearrangement, and oxidation. They are the most structurally diverse class of plant-based natural products with a wide range of biological activities and are widely found in nature. In recent years, scholars have conducted abundant studies on the structures and pharmacological properties of components of Curcumae Rhizoma. This article elucidates the chemical structures, medicinal properties, and biological properties of the sesquiterpenoids (a total of 274 compounds) isolated from Curcumae Rhizoma. We summarized extraction and isolation methods for sesquiterpenoids, established a chemical component library of sesquiterpenoids in Curcumae Rhizoma, and analyzed structural variances among sesquiterpenoids sourced from Curcumae Rhizoma of diverse botanical origins. Furthermore, our investigation reveals a diverse array of sesquiterpenoid types, encompassing guaiane-type, germacrane-type, eudesmane-type, elemane-type, cadinane-type, carane-type, bisabolane-type, humulane-type, and other types, emphasizing the relationship between structural diversity and activity. We hope to provide a valuable reference for further research and exploitation and pave the way for the development of new drugs derived from medicinal plants.

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Zedoarondiol inhibits atherosclerosis by regulating monocyte migration and adhesion via CXCL12/CXCR4 pathway

Cited by 13 publications

References 31 publications

Heterogeneity of macrophages in atherosclerosis revealed by single‐cell RNA sequencing

Heterogeneity of macrophages in atherosclerosis revealed by single‐cell RNA sequencing

Single-cell transcriptomic analysis reveals differential cell subpopulations and distinct phenotype transition in normal and dissected ascending aorta

Research Progress on Sesquiterpenoids of Curcumae Rhizoma and Their Pharmacological Effects

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