Zein in controlled drug delivery and tissue engineering

Paliwal, Rishi; Palakurthi, Srinath

doi:10.1016/j.jconrel.2014.06.036

Cited by 431 publications

(273 citation statements)

References 109 publications

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“…6 Due to this amphiphilic character, the hydrophobic regions of zein can aggregate into colloidal particles which are able to retain lipophilic drugs, while the polar regions can interact with water-soluble compounds. 10,11 This is why zein has been used to entrap drugs and nutraceuticals, eg, curcumin, 12 5-fluorouracil, 13 α-tocopherol, 14 lutein, 15 glibenclamide, 16 and essential oils. 17 However, due to their low net charge close to the isoelectric point (pI ≈6.2), the poor physical stability and dispersibility of freeze-dried zein nanoparticles at a neutral pH are detrimental to an efficacious application of this material in the alimentary and pharmaceutical fields.…”

Section: Gagliardi Et Almentioning

confidence: 99%

“…39 This finding could be explained by the presence of high levels of xanthophylls strongly bound to yellow zein, thus inducing low EE values of lipophilic drugs with respect to decolorized zein. 11 Conversely, the zein nanoparticles were able to retain a significant amount of the hydrophilic compound, thus evidencing their potential application as a useful carrier for water-soluble drugs (Table 5).…”

Section: Drug Entrapment Efficiencymentioning

confidence: 99%

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Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Gagliardi¹,

Paolino²,

Iannone³

et al. 2018

IJN

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Background The use of biopolymers is increasing in drug delivery, thanks to the peculiar properties of these compounds such as their biodegradability, availability, and the possibility of modulating their physico-chemical characteristics. In particular, protein-based systems such as albumin are able to interact with many active compounds, modulating their biopharmaceutical properties. Zein is a protein of 20–40 kDa made up of many hydrophobic amino acids, generally regarded as safe (GRAS) and used as a coating material. Methods In this investigation, zein was combined with various surfactants in order to obtain stable nanosystems by means of the nanoprecipitation technique. Specific parameters, eg, temperature, pH value, Turbiscan Stability Index, serum stability, in vitro cytotoxicity and entrapment efficiency of various model compounds were investigated, in order to identify the nanoformulation most useful for a systemic drug delivery application. Results The use of non-ionic and ionic surfactants such as Tween 80, poloxamer 188, and sodium deoxycholate allowed us to obtain nanoparticles characterized by a mean diameter of 100–200 nm when a protein concentration of 2 mg/mL was used. The surface charge was modulated by means of the protein concentration and the nature of the stabilizer. The most suitable nanoparticle formulation to be proposed as a colloidal drug delivery system was obtained using sodium deoxycholate (1.25% w/v) because it was characterized by a narrow size distribution, a good storage stability after freeze-drying and significant feature of retaining lipophilic and hydrophilic compounds. Conclusion The sodium deoxycholate-coated zein nanoparticles are stable biocompatible colloidal carriers to be used as useful drug delivery systems.

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Section: Gagliardi Et Almentioning

confidence: 99%

Section: Drug Entrapment Efficiencymentioning

confidence: 99%

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Gagliardi¹,

Paolino²,

Iannone³

et al. 2018

IJN

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“…As an alcohol-soluble protein obtained from corn, zein has been extensively investigated in the encapsulation of bioactive compounds because of its capability to form self-assembled NPs and more importantly, its capability for sustained drug release [23,24]. Due to the binding affinity to neutral polymers [25] and proteins [26] via hydrogen bonding and hydrophobic interactions respectively, TA and metal ions, were utilized to form robust nanoscale films on zein NPs.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular design of coordination bonding architecture on zein nanoparticles for pH-responsive anticancer drug delivery

Liang

Zhou

et al. 2015

Colloids and Surfaces B: Biointerfaces

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“…It is highly biocompatible (10,11), low cost and has versatile physical and mechanical properties that are suitable for being used in many different forms of drug delivery systems. For example, zein has been already successfully applied in the preparation of drug-loaded microspheres (3), films (4) and tablets (5).…”

Section: Introductionmentioning

confidence: 99%

The Development of Direct Extrusion-Injection Moulded Zein Matrices as Novel Oral Controlled Drug Delivery Systems

et al. 2015

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Purpose To evaluate the potential of zein as a sole excipient for controlled release formulations prepared by hot melt extrusion.Methods Physical mixtures of zein, water and crystalline paracetamol were hot melt extruded (HME) at 80ºC and injection moulded (IM) into caplet forms. HME-IM Caplets were characterised using differential scanning calorimetry, ATR-FTIR spectroscopy, scanning electron microscopy and powder X-ray diffraction. Hydration and drug release kinetics of the caplets were investigated and fitted to a diffusion model. ResultsFor the formulations with lower drug loadings, the drug was found to be in the noncrystalline state, while for the ones with higher drug loadings paracetamol is mostly crystalline.Release was found to be largely independent of drug loading but strongly dependent upon device dimensions, and predominately governed by a Fickian diffusion mechanism, while the hydration kinetics shows the features of Case II diffusion. ConclusionsIn this study a prototype controlled release caplet formulation using zein as the sole excipient was successfully prepared using direct HME-IM processing. The results demonstrated the unique advantage of the hot melt extruded zein formulations on the tuneability of drug release rate by alternating the device dimensions.

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Zein in controlled drug delivery and tissue engineering

Cited by 431 publications

References 109 publications

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system

Supramolecular design of coordination bonding architecture on zein nanoparticles for pH-responsive anticancer drug delivery

The Development of Direct Extrusion-Injection Moulded Zein Matrices as Novel Oral Controlled Drug Delivery Systems

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