Zelladhäsionsverhalten auf enantiomerenrein funktionalisierten Zeolith‐L‐Monoschichten

Abstract

Vorliebe für Krebszellen: Zeolith‐L‐Nanokristalle wurden enantioselekiv funktionalisiert und als enantiomorphe selbstorganisierte Monoschichten (SAMs) angeordnet. Das Adhäsionsverhalten verschiedener Zellen an diesen neuen Biomaterialien wurde bezüglich der Chiralität der entsprechenden Oberfläche untersucht. Dieses Konzept wurde zur Trennung von Primärzellen von Zelllinien angewendet (siehe Schema).

Supramolecular Organization in Confined Nanospaces

“…One remarkable exception is the family of composites produced by the inclusion of chromophores in zeolite L (LTL topology,). The fabrication of these hierarchically organized photoactive materials and their use as artificial antenna systems, pioneered by the Calzaferri group,,,,,, has been thoroughly investigated and the acquired knowledge played a seminal role, for example, in extending their scope to biomedical uses . Also importantly, dye‐zeolite L hybrids stimulated the quest of new host matrices for luminescent supramolecular systems: not only zeolite frameworks of diverse shape and composition,, but also mesoporous silicas/organosilicas,,,, 1D macrocycle channels,, and MOFs ,,…”

Manipulation and Orientation of Zeolite L by Using a Magnetic Field

“…[8] The organization of porous materials in polymers or surfaces and the use of loaded molecules to impart new properties to the aligned systems have been less explored. [27] Also, it has been employed for imaging purposes [28] and as a biocompatible surface for cell adhesion, [29,30] as well as other biomedical and drug-delivery studies. This permits restriction of the porosity to unidimensional channels that lead to a linear arrangement of entrapped molecules, which result in new optical, electrical, and magnetic properties.…”

“…The presence of solvent molecules in the channels of the crystals and cations, which compensate for the negatively charged framework, provides the opportunity to exchange ions or molecules with an appropriate size. [27] Also, it has been employed for imaging purposes [28] and as a biocompatible surface for cell adhesion, [29,30] as well as other biomedical and drug-delivery studies. [13,14] Along with their transparency in the visible spectral range, zeolite L permit the study of the photophysical properties of inserted organic dye molecules.…”

“…[20] Zeolite L has emerged as an appropriate host material for building artificial antenna systems, [21,22] (unidirectional) energytransfer materials, [21,23] and for the self-assembly of fluorescent supramolecular systems [24][25][26] and patterns. [27] Also, it has been employed for imaging purposes [28] and as a biocompatible surface for cell adhesion, [29,30] as well as other biomedical and drug-delivery studies. [31,32] The preferred orientation of such materials can result in new optical or electronic properties.…”