2021
DOI: 10.1055/a-1482-7752
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Zellbasierte Therapeutika zur Behandlung der Osteoarthritis beim Pferd

Abstract: ZusammenfassungIn den letzten Jahren haben zellbasierte Therapeutika zur Behandlung von Osteoarthritiden in der Pferdemedizin einen regelrechten Boom erlebt. In der Praxis werden diese Therapeutika in Eigenverantwortung des Tierarztes aus Patientenblut oder anderen körpereigenen Geweben wie Fettgewebe oder Knochenmark hergestellt. Auch wenn diesen zellbasierten Therapiemethoden das einheitliche therapeutische Konzept der regenerativen Medizin gemein ist, unterscheiden sie sich maßgeblich hinsichtlich Herstellu… Show more

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(5 citation statements)
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“…MSCs can be derived from mesenchymal tissues such as blood, bone marrow and adipose tissue, but do not represent a homogeneous stem cell population (41). In horses, commonly used MSC sources are fat, harvested from subcutaneous adipose tissue at the tail base (lipectomy) (54,55), bone marrow obtained by puncturing the sternum (56) or venous blood (40,57).…”
Section: Mesenchymal Stromal Cellsmentioning
confidence: 99%
See 4 more Smart Citations
“…MSCs can be derived from mesenchymal tissues such as blood, bone marrow and adipose tissue, but do not represent a homogeneous stem cell population (41). In horses, commonly used MSC sources are fat, harvested from subcutaneous adipose tissue at the tail base (lipectomy) (54,55), bone marrow obtained by puncturing the sternum (56) or venous blood (40,57).…”
Section: Mesenchymal Stromal Cellsmentioning
confidence: 99%
“…In horses, commonly used MSC sources are fat, harvested from subcutaneous adipose tissue at the tail base (lipectomy) (54,55), bone marrow obtained by puncturing the sternum (56) or venous blood (40,57). Following tissue harvesting, the process of MSC isolation and cultivation under laboratory conditions requires several weeks to obtain cell numbers usually used for intra-articular applications (41). Besides these autologous cultivated MSCs, commercially available MSC therapeutics are approved by the European Medicines Agency (EMA).…”
Section: Mesenchymal Stromal Cellsmentioning
confidence: 99%
See 3 more Smart Citations